Great amount of C.pneumoniae in ruptured plaque vessel segments at autopsy. A comparative study with stable plaques

Higuchi, Maria de Lourdes; Castelli, Jussara Bianchi; Aiello, Vera Demarchi; Palomino, Sueli; Reis, Marlene Paulino dos; Sambiase, Nadia Vieira; Fukasawa, S; Bezerra, Hiram G.; Ramires, José Antônio Franchini

doi:10.1590/s0066-782x2000000200005

Cited by 30 publications

(23 citation statements)

References 8 publications

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“…Therefore, they were present in greater amounts in ruptured plaques, which may be attributed to the fact that the vulnerable plaques are softer and contain a greater quantity of cholesterol, because the mycoplasmas only proliferate in cholesterol-rich media. Confirming previous findings 21 , the ruptured plaques also had elevated quantities of C. pneumoniae, which were present not only in the plaque, but also, and in higher numbers, in the adventitia. C. pneumoniae was present in the adventitia of almost all samples studied, independent of the presence of atherosclerosis.…”

Section: Discussionsupporting

confidence: 89%

“…In a previous study 21 using the techniques of immunohistochemistry, in situ hybridization (ISH), and electron microscopy, we reported a great amount of C. pneumoniae 1 3 1 3 1 3 1 3 1 3 bacteria in the intra-and extracellular space of atherosclerotic plaques, in the media layer, and mainly in the adventitia of segments of unstable coronary arteries. However, C. pneumoniae was also identified in segments of coronary arteries with stable plaques without atherosclerosis, mainly in the adventitia, suggesting that C. pneumoniae is a common infectious agent of the adventitia of vessels, and that its increased proliferation leads to inflammation of the vascular wall and may contribute to vessel remodeling.…”

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confidence: 99%

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Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction

Higuchi¹,

Reis²,

Sambiase³

et al. 2003

Arq. Bras. Cardiol.

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OBJECTIVE: To study atheromas, Mycoplasma pneumoniae (M. pneumoniae), and Chlamydia pneumoniae (C. pneumoniae). METHODS: C. pneumoniae was studied with immunohistochemistry and M. pneumoniae with in situ hybridization (ISH), in segments of coronary arteries (SCA) as follows: group A - thrombosed ruptured plaques (TRP) of 23 patients who died due to acute myocardial infarction (AMI); group B - 23 nonruptured plaques (NRP) of group A patients; group C - NRP of 11 coronary patients who did not die due to AMI; and group D - 11 SCA from patients with dilated cardiomyopathy or Chagas' disease without atherosclerosis. RESULTS: The mean number of C. pneumoniae+ cells/400x in groups A, B, C, and D was, respectively, 3.3±3.6; 1.0±1.3; 1.2±2.4; and 0.4±0.3; and the percentage of M. pneumoniae area was, respectively, 3.9±3.5; 1.5± 1.6; 0.9±0.9; and 0.4±0.2. More M. pneumoniae and C. pneumoniae were found in of group A than in group B (P<0.01). Good correlation was seen between the area of the vessel and the M. pneumoniae area in the plaque (r = 0.46; P=0.001) and between C. pneumoniae+ cells and CD4+ T lymphocytes (r = 0.42; P<0.01). The number of C. pneumoniae+ cells correlated with CD20+ B cells (r=0.48; P<0.01). CONCLUSION: M. pneumoniae and C. pneumoniae are more frequently found in TRP correlate with the intensity of the inflammation and diameter of the vessel (positive remodeling)

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction

Higuchi¹,

Reis²,

Sambiase³

et al. 2003

Arq. Bras. Cardiol.

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“…A histopathologic autopsy study that demonstrated a large number of Cpn organisms in ruptured plaques suggested possible involvement of Cpn in plaque rupture and development of acute myocardial infarction. 32) This observation prompted us to focus on the number of cells containing Cpn or CMV in coronary plaques. The purpose of this study was to investigate the number of Cpn-containing cells as well as CMVcontaining cells in coronary lesion specimens obtained from ACS and non-ACS patients who underwent thrombectomy or directional coronary atherectomy (DCA).…”

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confidence: 99%

Presence and Severity of Chlamydia pneumoniae and Cytomegalovirus Infection in Coronary Plaques Are Associated With Acute Coronary Syndromes

et al. 2006

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SUMMARYAlthough an association between Chlamydia pneumoniae (Cpn) or Cytomegalovirus (CMV) infection and coronary atherosclerosis has been reported, such an association is less clear for acute coronary syndromes (ACS). The purpose of this study was to investigate the pathogenic roles of Cpn and CMV infection of coronary plaques in ACS. We divided 38 coronary plaque specimens obtained from 38 patients who underwent directional coronary atherectomy or thrombectomy into an ACS group (n = 21) and a non-ACS group (n = 17). Cpn and CMV in specimens were stained using immunohistochemical techniques and analyzed quantitatively. The detection rate for either Cpn-or CMV-positive cells in ACS patients was slightly higher compared with non-ACS patients. Detection rates for both Cpn-and CMV-positive cells were significantly higher in ACS patients than in non-ACS patients (P = 0.010). Furthermore, the density of Cpn-and CMV-positive cells in plaques was significantly higher in ACS patients than in non-ACS patients (P < 0.003). The results indicate that the presence and severity of Cpn and CMV infection in coronary plaques are greater in patients with ACS compared with non-ACS patients. We conclude that infection with Cpn and CMV in coronary plaques may be involved in the pathogenesis of ACS. (Int Heart J 2006; 47: 511-519)

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“…We have previously reported that Chlamydia pneumoniae and Mycoplasma pneumoniae are present in atherosclerotic plaques 15,17,18 . Given the similarity between atherosclerosis and aortic valve stenosis, we hypothesized that such agents may also be present in AS and play an important role in the pathogenesis of the disease.…”

Section: Discussionmentioning

confidence: 98%

“…Chlamydia pneumoniae (CP) has been suggested to be involved in the pathogenesis of atherosclerosis, related with gene polymorphisms 14 and inflammation 15 but this still is a controversial matter [16][17][18] . CP has also been associated with the inflammatory processes of aortic valve lesions 19 .…”

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confidence: 99%

Chlamydia pneumoniae e Mycoplasma pneumoniae nos nódulos de calcificação da estenose da valva aórtica

Santos¹,

Pierri²,

Higuchi³

et al. 2005

Arq. Bras. Cardiol.

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Great amount of C.pneumoniae in ruptured plaque vessel segments at autopsy. A comparative study with stable plaques

Cited by 30 publications

References 8 publications

Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction

Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction

Presence and Severity of Chlamydia pneumoniae and Cytomegalovirus Infection in Coronary Plaques Are Associated With Acute Coronary Syndromes

Chlamydia pneumoniae e Mycoplasma pneumoniae nos nódulos de calcificação da estenose da valva aórtica

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