Great Desire for Extended Life and Health amongst the American Public

Donner, Yoni; Fortney, Kristen; Calimport, Stuart R. G.; Pfleger, K.; Shah, Munjal; Betts-LaCroix, Joe

doi:10.3389/fgene.2015.00353

Cited by 17 publications

(9 citation statements)

References 8 publications

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“…On the other side, 77% of the individuals not wanting to reach 100 years stated reasons expressing negative attitudes toward life in very old age. In a quantitative study based on a representative sample, Donner and colleagues (2016) assessed responses to two items: “How long do you wish to live?” and “If you could be physically and mentally the same as in your 20s, how long would like to live?” In response to the first item two-thirds (65%) preferred to live until 85 years, while under the condition of being healthy about 80% expressed a wish to live to at least 120 years (53% desired an unlimited lifetime).…”

Section: Desired and Expected Longevitymentioning

confidence: 99%

Motivation for Longevity Across the Life Span: An Emerging Issue

Lang

Rupprecht

2019

Innovation in Aging

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Over the past decades, increases in life expectancy in most modern societies have raised questions about whether and to what extent individuals value possible extensions of their personal lifetime. In this vein, a new field of research emerged that investigates the determinants, concomitants, and consequences of longevity values and personal preferences for an extended lifetime across adulthood. Based on a review of available theoretical and empirical work, we identified 3 mindsets on the challenges and potentials of human longevity common in research as well as personal views: (a) an essentialist mindset that builds on ideal principles of an infinite life, aimed at conquering or significantly postponing a biologically determined aging process, (b) a medicalist mindset that appraises aging as being primarily based on quality of health, and (c) a stoicist mindset that associates longevity and lifetime extension with the experience of grace and meaning. In this regard, we submit that motivation for longevity and its behavioral consequences differ depending on what mindsets individuals adopt in a given developmental context. We suggest that mindsets of longevity motivation are embedded in personal belief systems (e.g., death acceptance) that may depend on health, and on context influences (e.g., culture). Mindsets of longevity motivation may be related to differences in health behavior and late-life preparation. We illustrate such ideas with an exploratory analysis from a cross-cultural data set. We discuss the possible implications of these mindsets of longevity motivation for the aging sciences, and with regard to individual ways of approaching old age.

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Section: Desired and Expected Longevitymentioning

confidence: 99%

Motivation for Longevity Across the Life Span: An Emerging Issue

Lang

Rupprecht

2019

Innovation in Aging

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“…THE AIM OF PREVENTIVE MEDICINE is to prevent the occurrence or halting of disease and averting resulting complications . With a general increase in health awareness and a desire to live longer and healthier, a greater utilization of preventive medicine measures can be expected. The lack of ionizing radiation makes magnetic resonance imaging (MRI) attractive for whole‐body screening, aiming at the detection of disease before its symptomatic manifestation .…”

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confidence: 99%

Whole‐body MRI for preventive health screening: A systematic review of the literature

Kwee

2019

Magnetic Resonance Imaging

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BackgroundThe yield of whole‐body MRI for preventive health screening is currently not completely clear.PurposeTo systematically review the prevalence of whole‐body MRI findings in asymptomatic subjects.Study TypeSystematic review and meta‐analysis.SubjectsMEDLINE and Embase were searched for original studies reporting whole‐body MRI findings in asymptomatic adults without known disease, syndrome, or genetic mutation. Twelve studies, comprising 5373 asymptomatic subjects, were included.Field Strength/Sequence1.5T or 3.0T, whole‐body MRI.AssessmentThe whole‐body MRI literature findings were extracted and reviewed by two radiologists in consensus for designation as either critical or indeterminate incidental finding.Statistical TestsData were pooled using a random effects model on the assumption that most subjects had ≤1 critical or indeterminate incidental finding. Heterogeneity was assessed by the I 2 statistic.ResultsPooled prevalences of critical and indeterminate incidental findings together and separately were 32.1% (95% confidence interval [CI]: 18.3%, 50.1%), 13.4% (95% CI: 9.0%, 19.5%), and 13.9% (95% CI: 5.4%, 31.3%), respectively. There was substantial between‐study heterogeneity (I 2 = 95.6–99.1). Pooled prevalence of critical and indeterminate incidental findings together was significantly higher in studies that included (cardio)vascular and/or colon MRI compared with studies that did not (49.7% [95% CI, 26.7%, 72.9%] vs. 23.0% [95% CI, 5.5%, 60.3%], P < 0.001). Pooled proportion of reported verified critical and indeterminate incidental findings was 12.6% (95% CI: 3.2%, 38.8%). Six studies reported false‐positive findings, yielding a pooled proportion of 16.0% (95% CI: 1.9%, 65.8%). None of the included studies reported long‐term (>5‐year) verification of negative findings. Only one study reported false‐negative findings, with a proportion of 2.0%.Data ConclusionPrevalence of critical and indeterminate incidental whole‐body MRI findings in asymptomatic subjects is overall substantial and with variability dependent to some degree on the protocol. Verification data are lacking. The proportion of false‐positive findings appears to be substantial. Level of Evidence: 4 Technical Efficacy: Stage 3J. Magn. Reson. Imaging 2019;50:1489–1503.

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“…When the extended healthspan was postulated in questionnaire design, responses largely favored longer life. For example, in a recent survey by Donner et al 20% of respondents wanted to live to the age of 85, while 42% wanted that their life expectancy would not be limited [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives

Vaiserman

Lushchak

2017

J Transl Med

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BackgroundMost modern societies undergo rapid population aging. The rise in life expectancy, nevertheless, is not accompanied, to date, by the same increment of healthspan. Efforts to increase healthspan by means of supplements and pharmaceuticals targeting aging-related pathologies are presently in spotlight of a new branch in geriatric medicine, geroscience, postulating that aging could be manipulated in such a way that will in parallel allow delay the onset of all age-associated chronic disorders.DiscussionCurrently, the concept of the “longevity dividend” has been developed pointed out that the extension of healthspan by slowing the rate of aging is the most efficient way to combat various aging-related chronic illnesses and disabling conditions than combating them one by one, what is the present-day approach in a generally accepted disease-based paradigm. The further elaboration of pharmaceuticals specifically targeted at age-associated disorders (commonly referred to as ‘anti-aging drugs’) is currently one of the most extensively developed fields in modern biogerontology. Some classes of chemically synthesized compounds and nutraceuticals such as calorie restriction mimetics, autophagy inductors, senolytics and others have been identified as having potential for anti-aging intervention through their possible effects on basic processes underlying aging. In modern pharmaceutical industry, development of new classes of anti-aging medicines is apparently one of the most hopeful directions since potential target group may include each adult individual.SummaryImplementation of the geroscience-based approaches into healthcare policy and practice would increase the ratio of healthy to unhealthy population due to delaying the onset of age-associated chronic pathologies. That might result in decreasing the biological age and increasing the age of disability, thus increasing the age of retirement and enhancing income without raising taxes. Economic, social and ethical aspects of applying the healthspan- and lifespan-promoting interventions, however, have to be comprehensively debated prior to their implementation in public health practice.

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Great Desire for Extended Life and Health amongst the American Public

Cited by 17 publications

References 8 publications

Motivation for Longevity Across the Life Span: An Emerging Issue

Motivation for Longevity Across the Life Span: An Emerging Issue

Whole‐body MRI for preventive health screening: A systematic review of the literature

Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives

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