Greater Celandine hepatotoxicity: a clinical review

Teschke, Rolf; Frenzel, Christian; Glass, Xaver; Schulze, Johannes; Eickhoff, Axel

doi:10.1016/s1665-2681(19)31408-5

Cited by 44 publications

(48 citation statements)

References 27 publications

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“…One type is the PA‐related HSOS from the herbal TCM G. segetum (Table ), in analogy to other PA‐containing herbs of TCM and non‐TCM . The other type develops independently from PAs (Tables and ) and is similar to other herbs lacking PAs related to TCM or non‐TCM, with some examples such as kava, Indian Ayurvedic herbs, Greater Celandine, aloe, chaparral, germander, mistletoe and senna …”

Section: Likelihood Of Causalitymentioning

confidence: 99%

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Review article: herbal hepatotoxicity - an update on traditional Chinese medicine preparations

Teschke

Wolff

Frenzel

et al. 2014

Aliment Pharmacol Ther

134

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SUMMARY BackgroundAlthough evidence for their therapeutic efficacy is limited, herbal traditional Chinese medicine (TCM) preparations increasingly gain popularity. In contrast to other herbal products, adverse effects by herbal TCM including liver toxicity were rarely reported. In recent years, more cases were published, providing new clinical challenges. AimTo summarise comprehensively the literature on herbal TCM hepatotoxicity since 2011. MethodsPubMed was searched using key words related to TCM, the results were restricted to full English-language publications and abstracts published since 2011. In addition, the database of the National Institutes of Health (NIH) and LiverTox was accessed under the topic 'Drug record: Chinese and other Asian herbal medicines'. ResultsSince 2011, new case reports and case series provided evidence for herbal hepatotoxicity by TCM, focusing on nine TCM herbal mixtures and four individual TCM herbs with potential health hazards. These were the TCM products Ban Tu Wan, Chai Hu, Du Huo, Huang Qin, Jia Wei Xia Yao San, Jiguja, Kamishoyosan, Long Dan Xie Gan Tang, Lu Cha, Polygonum multiflorum products, Shan Chi, 'White flood' containing the herbal TCM Wu Zhu Yu and Qian Ceng Ta, and Xiao Chai Hu Tang. Other developments include the establishment of a new and early diagnostic serum marker for hepatotoxicity caused by pyrrolizidine alkaloids, assessed using ultra performance liquid chromatography-mass spectrometry analysis, and new regulatory details to improve herbal TCM product quality and safety. ConclusionStringent evaluation of the risk/benefit ratio is essential to protect traditional Chinese medicines users from health hazards including liver injury.

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Section: Likelihood Of Causalitymentioning

confidence: 99%

“…In HILI cases unrelated to TCM, comedication with other herbs and synthetic drugs is common and considered a potential metabolic interaction at the hepatic microsomal cytochrome P450 (CYP) system . In HILI reports related to TCM and published since 2011, comedication was rarely mentioned or excluded (Tables and ).…”

Section: Herb–drug Interactionsmentioning

confidence: 99%

Review article: herbal hepatotoxicity - an update on traditional Chinese medicine preparations

Teschke

Wolff

Frenzel

et al. 2014

Aliment Pharmacol Ther

134

View full text Add to dashboard Cite

show abstract

“…Strahl et al ., 1998 , Greving et al ., 1998 , Benninger et al ., 1999 , Crijns et al ., 2002 , Hardeman et al ., 2003 , Stickel et al ., 2003 , BfArM, 2005 , Rifai et al ., 2006 , Conti et al ., 2008 , Moro et al ., 2009 , Tarantino et al ., 2009 , EMA, 2010 , Teschke et al ., 2011, 2012 …”

Section: Reported Cases Of Herbal Hepatotoxicity As Tabular Compilationmentioning

confidence: 99%

Herbal hepatotoxicity: a tabular compilation of reported cases

Teschke

Wolff

Frenzel

et al. 2012

Liver International

Self Cite

116

113

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“…In literature, there are several reports on liver toxicity associated with application of herbal preparations derived from C. majus (Teschke et al, 2012;Stickel et al, 2003;De Smet, 2002;Strahl et al, 1998).…”

Section: Introductionmentioning

confidence: 99%