Greater concentrations of IGF-1 are associated with increasing pregnancy rate in melatonin implanted anestrous Barki ewes

El-Mokadem, M.Y.; El-Din, A.N.M. Nour; Ramadan, Tamer; Taha, Taha A.; Samak, M. A.; Sharaby, Mahmoud A.; Rashad, Amr M.A.

doi:10.1016/j.anireprosci.2020.106542

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…IGF1 guides GnRH neurons during puberty, and the IGF1 pathway appeared more relevant for the onset of puberty in cattle (Fortes et al, 2013). Furthermore, IGF‐1 (El‐Mokadem et al, 2020), PGF (Binder et al, 2016), ITGBs (Bu et al, 2022) and KDR (Chevillard et al, 2022) were all associated with increasing the reproduction ratio for ruminants. Transcription factors were proteins that control gene expression by binding and unbinding near coding regions to regulate the transcriptional machinery.…”

Section: Discussionmentioning

confidence: 99%

An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore the onset of puberty

Gao

Ren

Zhang

et al. 2023

Reprod Domestic Animals

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The time of puberty onset is crucial for female animal, as it can affect the generation interval, feeding costs and the utilization of animals. However, little is known about the mechanism of hypothalamic lncRNAs (long noncoding RNAs) in regulatory goat puberty onset. Therefore, genome‐wide transcriptome analysis was performed in goats to clarify the roles of hypothalamic lncRNAs and mRNAs in the onset of puberty. In the present study, the co‐expression network of differentially expressed (DE) mRNAs in goat hypothalamus identified FN1 as the hub gene, and ECM‐receptor interaction, Focal adhesion and PI3K‐Akt signalling pathways are involved in puberty. We also observed the crucial hub transcription factors (TCF12, STAT1, STAT2, GATA3 and TEAD4) associated with reproduction and puberty. Then, genetic correlation analysis of DE mRNAs and DE lncRNAs identified the key lncRNAs involved in puberty. This research supplies a resource for transcriptome studies in goat puberty and indicated DE lncRNAs in the ECM‐receptor interaction pathway were novel candidate regulators for genetic studies on female reproduction.

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Section: Discussionmentioning

confidence: 99%

An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore the onset of puberty

Gao

Ren

Zhang

et al. 2023

Reprod Domestic Animals

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Implications of negative energy balance in lactating Barki and Rahmani ewes

Anwar

El-Mokadem²,

Ramadan³

et al. 2022

Anim. Prod. Sci.

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Context During lactation, ewes usually undergo a state of negative energy balance since the energy required for milk production and maintenance of body tissue functions exceeds energy ingested. Aims This study was performed to explore the impact of negative energy balance associated with lactation on milk yield and composition, metabolic profile and some reproductive traits in two different breeds of sheep. Methods In total, one hundred lactating Barki and Rahmani ewes (50 ewes per breed) were used for six consecutive parities to investigate the effects of breed, parity, week of lactation, and their interactions on milk yield and composition, including percentages of milk fat and milk protein, fat–protein ratio, energy-corrected milk, milk energy value, energy balance, some serum metabolites and reproductive traits. Milk and blood samples were collected weekly throughout the study. Key results Rahmani ewes had higher milk fat %, fat yield, protein %, protein yield and milk energy value, but lower fat–protein ratio than did Barki ewes. The greater value of energy balance and accumulated negative energy balance from parturition to energy balance equilibrium and fewer days from lambing to energy balance equilibrium were observed in Rahmani than in Barki ewes. Greater values of serum concentrations of total protein, albumin, cholesterol and lower values of aspartate aminotransferase and alanine aminotransferase were recorded in Rahmani than in Barki ewes. Reproductive traits, including days to the first oestrus and days to conception, recorded greater values in Barki than in Rahmani ewes. Conclusion Rahmani ewes possessed adaptive characteristics to the challenge of lactation, expressed as a lower value of fat–protein ratio, which indicated a tendency of energy balance stabilisation, than did Barki ewes. This tendency was reflected in improved reproductive traits by reducing days to first oestrus and days to conception in Rahmani compared with Barki ewes. Implications Lactation presents a critical stressful period in the dam productive life because of the high nutritional and other managerial requirements necessary for milk production. This study was conducted to assess and compare the sustainability of the two sheep breeds to the production expenditure during lactation.

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Effects of melatonin implants on reproductive performance in sheep: a systematic review and meta-analysis

Uzabacı,

Ustuner

2024

Anim. Prod. Sci.

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Context Sheep are seasonal breeding animals. Different reproduction systems exist to enhance productivity in non-breeding season. One of the methods used in enhancing reproductive performance in sheep breeding is melatonin administration. Aim This study aimed to evaluate the impact of melatonin application on reproductive performance in sheep by meta-analysis according to different factors. Methods To find eligible studies, PubMed and Web of Science databases were searched. Twenty studies published between 1991 and 2021 were included in the meta-analysis. The effect sizes of pregnancy rate, lambing rate and litter size were calculated according to breeds, production characteristics (dairy-meat breeds) and season (breeding–non-breeding). The study estimated the risk ratio for pregnancy and lambing rates, and standardized mean difference for litter size as effect size. Key results The melatonin hormone increases the pregnancy rate by 1.07 times and the lambing rate by 1.36 times. The effect size (risk ratio) of the Rasa Aragonesa breed (1.15) for pregnancy rate and the Merino breed (1.65) for lambing rate was higher than the Sarda breed. Conclusions The positive effect of melatonin was found to be higher in the non-breeding season than in the breeding season for the three reproductive performance traits examined. Implications This study is a comprehensive research study examining the effect of melatonin application in sheep according to different factors.

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Greater concentrations of IGF-1 are associated with increasing pregnancy rate in melatonin implanted anestrous Barki ewes

Cited by 3 publications

References 31 publications

An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore the onset of puberty

An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore the onset of puberty

Implications of negative energy balance in lactating Barki and Rahmani ewes

Effects of melatonin implants on reproductive performance in sheep: a systematic review and meta-analysis

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