Greater functional activation during galvanic vestibular stimulation is associated with improved postural stability: a GVS-fMRI study

Mitsutake, Tsubasa; Sakamoto, Maiko; Kawaguchi, Atsushı; Tamari, Makoto; Horikawa, Etsuo

doi:10.1080/08990220.2020.1803256

Cited by 11 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another study in non‐vestibular regions using diffuse correlation functional spectroscopy and real‐time NIRS, it was found that cerebral blood flow increases in the ipsilateral hemisphere of stimulation, with an increase in cerebral blood flow of 10% during anodic stimulation and 11% during cathodic stimulation, as well as an increase in HbO 2 concentration during anodic and cathodic stimulation, accompanied by a decrease in Hb concentration during anodic and cathodic stimulation (Giovannella et al, 2018). In a study using functional magnetic resonance imaging, the oxygenation level‐dependent blood flow signal was significantly higher during GVS in the parietal operculum, central operculum, and opercular part of the inferior frontal gyrus (Mitsutake et al, 2020). In addition to these, in our study, for the first time, we report that the haemodynamic response in the cerebral cortex is similar when GVS and positive control stimuli are applied to evaluate the activation of the vestibular cortex.…”

Section: Discussionmentioning

confidence: 99%

“…The use of diffuse correlation functional spectroscopy and real‐time near‐infrared spectroscopy showed that cerebral blood flow increases in the ipsilateral hemisphere of stimulation (AF7 was the stimulation electrode while PO8 was the return electrode), with an increase in blood flow of 10% during anodic stimulation and 11% during cathodic stimulation, as well as an increase in HbO 2 concentration during anodic and cathodic stimulation, accompanied by a decrease in deoxyhaemoglobin (Giovannella et al, 2018). The use of functional magnetic resonance imaging showed that oxygenation level‐dependent blood flow signal is significantly higher during GVS in the parietal operculum, central operculum, and opercular part of the inferior frontal gyrus (Mitsutake et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Galvanic vestibular stimulation activates the parietal and temporal cortex in humans: A functional near‐infrared spectroscopy (fNIRS) study

Hernández‐Román,

Montero‐Hernández,

Vega

et al. 2023

Eur J of Neuroscience

View full text Add to dashboard Cite

Galvanic vestibular stimulation (GVS) helps stabilize subjects when balance and posture are compromised. This work aimed to define the cortical regions that GVS activates in normal subjects. We used functional near-infrared spectroscopy (fNIRS) to test the hypothesis that GVS activates similar cortical areas as a passive movement. We used transcranial current stimulation (cathode in the right mastoid process and anode in the FPz frontopolar point) of bipolar direct current (2 mA), false GVS (sham), vibration (neutral stimulus), and back and forth motion (positive control of vestibular movement) in 18 clinically healthy volunteers. Seventy-two brain scans were performed, applying a crossover-type experimental design. We measured the heart rate, blood pressure, body temperature, head capacitance, and resistance before and after the experiment. The haemodynamic changes of the cerebral cortex were recorded with an arrangement of 26 channels in four regions to perform an ROI-level analysis. The back-and-forth motion produced the most significant oxygenated haemoglobin (HbO 2 ) increase. The response was similar for the GVS stimulus on the anterior and posterior parietal and right temporal regions. Sham and vibrational conditions did not produce significant changes ROI-wise. The results indicate that GVS produces a cortical activation coherent with displacement percept.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Galvanic vestibular stimulation activates the parietal and temporal cortex in humans: A functional near‐infrared spectroscopy (fNIRS) study

Hernández‐Román,

Montero‐Hernández,

Vega

et al. 2023

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Use of GVS resulted in cell proliferation in the ipsilesional Medial Vestibular Nuclei (MVN), fast rebalancing in vestibular nuclei, modulation in motor outputs and speeding up in static and dynamic vestibular compensation in unilaterally labyrinthectomized rats [39] and improved balance and reduced body sway in normal subjects [27]. An fMRI study showed that more functional activation in the central operculum in GVS intervention could be the main factor in standing posture stability [45]. The mean of VOR gain after the intervention significantly improved in the VR and VR+nGVS groups in all affected semicircular canals.…”

Section: Discussionmentioning

confidence: 99%

Combining Vestibular Rehabilitation and Noisy Galvanic Vestibular Stimulation for Treatment of Unilateral Vestibulopathy: A Randomized Controlled Trial

Khavarghazalani,

Ghahraman,

Hoseinabadi

et al. 2023

AVR

View full text Add to dashboard Cite

Background and Aim: Vestibular Rehabilitation (VR) is a well-accepted treatment for Unilateral Vestibulopathy (UVP). Since noisy Galvanic Vestibular Stimulation (nGVS) improves the processing of vestibular inputs, we assessed the synergistic effects of adding nGVS to vestibular rehabilitation for the treatment of UVP. Methods: Patients with UVP were randomly assigned into two groups receiving either VR for four weeks (VR group, n=12) or VR for four weeks combined with nGVS for three sessions (VR+nGVS group; n=12). Outcome measurements were postural control parameters measured with eyes open/closed conditions on hard/soft surfaces, Vestibulo-Ocular Reflex (VOR) gain, and Dizziness Handicap Inventory (DHI) scores that were assessed at baseline and after four weeks. Results: All postural control parameters, mean total and subscale scores of DHI, and mean VOR gain in directions of affected canals significantly improved in both groups after interventions (p<0.05) except mean mediolateral displacement in conditions with eyes closed on hard surface and with eyes open on soft surface, mean mediolateral velocity in conditions with eyes closed on hard surface, ability to stance with eye closed condition on soft surface and mean emotional subscale of DHI in VR group. Improvements were significantly higher in postural control outcomes measured in stances with eyes closed on hard surface and with eyes open and closed on soft surface, mean VOR gains in directions of affected horizontal and anterior canals, and mean total, physical, and functional scores of DHI in VR+nGVS group (p<0.05). Conclusion: When combined with VR, nGVS shows additional therapeutic effects in UVP patients. Keywords: Unilateral peripheral vestibulopathy; vestibular compensation; galvanic vestibular stimulation; vestibular rehabilitation; postural control

show abstract

“…Interestingly, significantly increased brain activity in the central operculum was found both in the noisy and conventional GVS groups. Functional activation of the central operculum may be linked to the integration of multisensory data necessary for standing [15]. Noisy GVS was found to improve body balance while standing with the eyes closed [16] and during dynamic walking [17], while conventional GVS was shown to modulate the position of the center of pressure in patients with hemiparesis [3].…”

Section: Discussionmentioning

confidence: 99%

Comparing activated brain regions between noisy and conventional galvanic vestibular stimulation using functional magnetic resonance imaging

2021

Self Cite

View full text Add to dashboard Cite

Objective Galvanic vestibular stimulation (GVS) enhances vestibular sensory inputs in vestibular afferents. However, it is unclear whether noisy and conventional GVS activate different regions of the brain. The purpose of this study was to investigate the differences in activated brain regions between those two interventions using functional MRI (fMRI).Methods Twenty-four healthy volunteers who met the inclusion/exclusion criteria were randomly assigned to the noisy GVS or conventional GVS groups. Brain activity was measured during stimulation and compared with that during resting fMRI. This study used a blocked design comprising four task-rest blocks, each consisting of a 30-s period of vestibular stimulation followed by a 30-s period of rest. We evaluated the differences in contrast images between the noisy and conventional GVS groups. ResultsThe noisy GVS group showed significantly increased activation in the vestibular system-related brain regions, including the insula and central operculum. The conventional GVS group showed significant activity in multisensory areas, including the supramarginal gyrus, central operculum and opercular part of the inferior frontal gyrus. Thus, the noisy GVS group showed significantly increased activity in the insula, putamen and central operculum compared with the conventional GVS group. ConclusionsNoisy GVS could increase brain activity in the insular peripheral region compared to conventional GVS. Our results extend the literature about the importance of the stochastic resonance of noise addition for the vestibular system.

show abstract

Greater functional activation during galvanic vestibular stimulation is associated with improved postural stability: a GVS-fMRI study

Cited by 11 publications

References 29 publications

Galvanic vestibular stimulation activates the parietal and temporal cortex in humans: A functional near‐infrared spectroscopy (fNIRS) study

Galvanic vestibular stimulation activates the parietal and temporal cortex in humans: A functional near‐infrared spectroscopy (fNIRS) study

Combining Vestibular Rehabilitation and Noisy Galvanic Vestibular Stimulation for Treatment of Unilateral Vestibulopathy: A Randomized Controlled Trial

Comparing activated brain regions between noisy and conventional galvanic vestibular stimulation using functional magnetic resonance imaging

Contact Info

Product

Resources

About