2008
DOI: 10.1016/j.brainres.2008.01.030
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Greater intake of vitamins B6 and B12 spares gray matter in healthy elderly: A voxel-based morphometry study

Abstract: Previous studies have reported that high concentrations of homocysteine and lower concentrations of vitamin B6, B12, and folate increase the risk for cognitive decline and pathology in aging populations. In this cross-sectional study, high-resolution magnetic resonance imaging (MRI) scans and a 3-day food diary were collected on 32 community-dwelling adults between the ages of 59 and 79. We examined the relation between vitamin B6, B12, and folate intake on cortical volume using an optimized voxel-based morpho… Show more

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Cited by 39 publications
(35 citation statements)
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“…In the Framingham Offspring study, total Hcy levels were inversely related to frontal lobe volume (Seshadri et al, 2008), and a voxel-based morphometry assessment of B vitamin supplementation specifically implicated a similar location in humans (Erickson et al, 2008). Most additional anatomic regions identified in the latter study corresponded to our regional gray matter findings in monkeys.…”
Section: Discussionmentioning
confidence: 99%
“…In the Framingham Offspring study, total Hcy levels were inversely related to frontal lobe volume (Seshadri et al, 2008), and a voxel-based morphometry assessment of B vitamin supplementation specifically implicated a similar location in humans (Erickson et al, 2008). Most additional anatomic regions identified in the latter study corresponded to our regional gray matter findings in monkeys.…”
Section: Discussionmentioning
confidence: 99%
“…Aging is also associated with a variety of cognitive deficits with executive control and memory processes subserved by prefrontal and medial temporal lobe regions particularly affected (see Balota, Dolan, & Duchek, 2000; Hasher & Zacks, 1988, for reviews). Several factors have emerged that may moderate structural and functional declines in old age, including exercise (e.g., Bugg & Head, in press; Colcombe et al, 2005), physiological factors (e.g., Erickson et al, 2008; MacLullich et al, 2005), and mental health (e.g. Gunning-Dixon et al, 2008; Yehuda et al, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…Symptoms of vitamin B12 deficiency include fatigue, weakness, anorexia, paresthesias, numbness and dizziness. Early diagnosis and prompt treatment of patients in the early stage of the disorder can often produce an improvement in their condition (Erickson et al, 2008;Melinda, 2006;Mohammad et al, 2010).…”
Section: Introductionmentioning
confidence: 99%