Greater mandibular horizontal condylar angle is associated with temporomandibular joint osteoarthritis

Lee, Peggy P.; Stanton, Alexander R.; Hollender, L

doi:10.1016/j.oooo.2016.12.008

Cited by 22 publications

(27 citation statements)

References 16 publications

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“…However, in 18.9% (11/58) of the MLD patients, the HCA was smaller on the shifted side than on the contralateral side joints. Lee et al 15 also reported similar findings: the affected joint angles were smaller than the unaffected contralateral joints in 22% (13/60) of the unilateral OA patients. These findings warrant further investigation.…”

Section: Discussionsupporting

confidence: 52%

“…These findings indicated that the shifted side-contralateral side difference was manifested in structural changes of the joint. In a study using CT data, Lee et al 15 showed that, in patients with unilateral TMJ OA, the average HCA in the unilaterally OA-affected joints was significantly greater than in the unaffected joints on the contralateral side. Their subsequent longitudinal study found that a greater HCA was associated with TMJ OA, and they concluded that the clinical progression of OA preceded the increases in HCA.…”

Section: Discussionmentioning

confidence: 99%

“…11 Different studies have shown that a greater HCA was associated with disc displacement and degenerative changes. [11][12][13][14][15][16] Lee et al 15 reported that a larger HCA was associated with moderate to severe OA. Their subsequent longitudinal study showed that the initial progression of OA preceded increases in HCA.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of horizontal condylar angle in malocclusions with mandibular lateral displacement using cone-beam computed tomography

Velásquez¹,

Coro²,

Bustillo³

et al. 2021

The Angle Orthodontist

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Objectives To evaluate the horizontal condylar angle (HCA) in mandibular lateral displacement (MLD). Materials and Method s: HCA in MLD malocclusions were examined using cone-beam computed tomography data in subjects with MLD and control subjects. Results HCA in joints of control patients and contralateral side joints of MLD patients were not significantly different. The mean HCA on the shifted side was larger than on the contralateral side (P < .001) in the different HCA groups. HCA was significantly larger on the shifted side than on the contralateral side in skeletal Class I, Class II, and Class III groups (P < .001). Conclusions (1) There was no statistically significant difference between HCA in control patients and on the contralateral side in MLD patients. (2) HCA was significantly larger on the shifted side than on the contralateral side. (3) HCA on the shifted side and the contralateral side in MLD Class I, Class II, and Class III are significantly different.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of horizontal condylar angle in malocclusions with mandibular lateral displacement using cone-beam computed tomography

Velásquez¹,

Coro²,

Bustillo³

et al. 2021

The Angle Orthodontist

View full text Add to dashboard Cite

show abstract

“…This different pattern that was found in participants with osteoarthrosis may be associated with greater horizontal condyle angulation in relation to this disease, as demonstrated by Lee et al (27) through computed tomography exams. According to these authors, the greater condyle angulation precedes the appearance of osteoarthrosis (28).…”

Section: Discussionmentioning

confidence: 99%

Understanding the role of osteoarthrosis on electromyographic activity of masticatory muscles and quality of life

Righetti

Taube²,

Palinkas

et al. 2020

J Clin Exp Dent

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“…Matrix metalloproteinases (MMPs) and A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are also involved in the disease process 5 . In recent years, it has also been reported that new blood vessels, the horizontal angle of the mandibular condyle, and the absence of posterior teeth are related to the occurrence of TMJOA 6‐8 . However, none of these theories can fully elucidate the disease's etiology.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐101a‐3p could be involved in the pathogenesis of temporomandibular joint osteoarthritis by mediating UBE2D1 and FZD4

Mao

Wei

et al. 2020

J Oral Pathology Medicine

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Background Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease that gradually affects the articular cartilage, synovium, and bone structure. To date, the molecular mechanism of TMJOA pathogenesis remains unclear. The aim of this study was to explore the biological function of the micro‐ribonucleic acid 101a‐3p (miR‐101a‐3p) and its role in TMJOA. Methods We detected the effect of interleukin‐1β (IL‐1β) on chondrocyte proliferation using Cell Counting Kit‐8 (CCK‐8) technology. Using quantitative polymerase chain reaction (qPCR), we detected transcription levels of miR‐101a‐3p in a rat model with TMJOA and inflamed chondrocytes, as well as in a group of normal rats. The effect of miR‐101a‐3p on apoptosis was examined in vitro using flow cytometry (FCM). We then analyzed the target of miR‐101a‐3p via bioinformatics and confirmed it using a luciferase reporter assay (LRA). Results We showed that IL‐1β could inhibit proliferation of chondrocytes. We found that miR‐101a‐3p levels were significantly lower in the rat inflammation model with TMJOA and inflamed chondrocytes than in the normal group. Additionally, miR‐101a‐3p substantially promoted apoptosis of chondrocytes, and both bioinformatic analyses and LRA found that this miRNA targeted the genes ubiquitin‐conjugating enzyme 2D1 (UBE2D1) and Frizzled class receptor 4 (FZD4). Conclusion Our results suggested that miR‐101a‐3p was involved in the pathogenesis of TMJOA and that its mechanism was probably interaction with its target genes UBE2D1 and FZD4.

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Greater mandibular horizontal condylar angle is associated with temporomandibular joint osteoarthritis

Cited by 22 publications

References 16 publications

Evaluation of horizontal condylar angle in malocclusions with mandibular lateral displacement using cone-beam computed tomography

Evaluation of horizontal condylar angle in malocclusions with mandibular lateral displacement using cone-beam computed tomography

Understanding the role of osteoarthrosis on electromyographic activity of masticatory muscles and quality of life

MicroRNA‐101a‐3p could be involved in the pathogenesis of temporomandibular joint osteoarthritis by mediating UBE2D1 and FZD4

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