Greater occipital and supraorbital nerve blockade for the preventive treatment of migraine: a single-blind, randomized, placebo-controlled study

Özer, Duygu; Bölük, Cem; Börü, Ülkü Türk; Altun, Deniz; Taşdemir, Mustafa; Toksoy, Cansu Köseoğlu

doi:10.1080/03007995.2018.1532403

Cited by 20 publications

(45 citation statements)

References 37 publications

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“…In a comparative review study of 4031 chronic migraine patients conducted with a placebo group, a significant reduction in monthly headache episodes was determined following the injection of botulinum toxin compared to the placebo. However, no change was shown in episodic migraine (11).…”

Section: Discussionmentioning

confidence: 87%

“…In the same review, it was found that BTX-A and placebo application did not significantly differ concerning the outcome of a 50% reduction in headache episodes per month for migraine or episodic migraine. In the same study, it was demonstrated that BTX-A could improve the impact of chronic migraine after 16 weeks of therapy, but this effect was not seen in episodic migraine (11). The side-effects reported in the review were myalgia, musculoskeletal stiffness, neck pain, paresthesia, blepharoptosis and neck weakness (11).…”

Section: Discussionmentioning

confidence: 95%

“…A retrospective study by Guerzoni et al reported a 67% reduction in acute drug intake and a 34% reduction in headache days (9). A Spanish study of 115 patients reported that chronic migraine became episodic migraine and the rate of response to treatment was 68.7% (10).…”

Section: Discussionmentioning

confidence: 99%

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Peripheral Nerve Blockade and Botox Treatment in Chronic Migraine: A Comparative Study

Bilgiç¹,

Akpınar²,

Börü

et al. 2021

J Current Med Res Opinion

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Migraine is the most commonly encountered disabling headache. Chronic migraine significantly affects the quality of life and reduces the ability to attend work and social events, and consequently becomes an increasing economic burden.In recent years, peripheral nerve block with botulinum toxin A (botox) and local analgesics has been included in alternative treatment regimens.In cases of chronic migraine, botox is injected into the facial area, maxillary and mandibular nerve, and the head and neck muscles.Recent methods such as great occipital nerve (GON), and lesser occipital nerve, supra orbital nerve (SON), sphenopalatine ganglion blockade and trigeminal ganglion blockade have been applied using local analgesics. GON and SON blockade are the most frequently used of these methods. Studies related to these methods have shown a decrease in the frequency and severity of migraine pain.The results of this study showed that both GON and SON blockade and long-term application of BTX-A treatment were highly effective in the treatment of chronic migraine and both treatment methods had a similar level of effectiveness.That the follow-up period of this study was longer than in previous research can be considered a strong aspect of the study.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 95%

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Peripheral Nerve Blockade and Botox Treatment in Chronic Migraine: A Comparative Study

Bilgiç¹,

Akpınar²,

Börü

et al. 2021

J Current Med Res Opinion

View full text Add to dashboard Cite

show abstract

“…However, Dilli et al (10) did not differentiate between the patients as episodic and chronic, and they performed a greater ONB only once. In a single-blind, randomized, and placebo-controlled study of greater occipital and supraorbital nerve block by Özer et al (11), they showed that greater ONB and supraorbital nerve block with lidocaine was more effective than placebo in the prophylactic treatment of both episodic and chronic migraine. In the present study, we found that bilateral greater and lesser ONBs that we applied in three sessions (with a mixture of methylprednisolone, prilocaine, and bupivacaine) at 15-day intervals were effective and safe in the prophylaxis of episodic migraine without aura.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Bilateral Greater and Lesser Occipital Nerve Blocks in the Prophylaxis of Episodic Migraine

Güneş

Özeren

2021

Düzce Tıp Fakültesi Dergisi

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Aim: In recent years, many studies have been conducted on the effectiveness of occipital nerve block (ONB) especially in the prophylaxis of chronic migraine. In this study, it was aimed to investigate the effectiveness of bilateral greater and lesser ONBs in the prophylaxis of episodic migraine without aura. Material and Methods: This retrospective study included patients with episodic migraine without aura who underwent bilateral greater and lesser ONBs between January 2018 and December 2019. Information about headache frequency, attack duration, and pain severity (VAS score) of the patients in the last month before nerve block and 1 month after nerve block was retrieved from the database and recorded for statistical analysis. Results: A total of 17 patients aged 26-57 years were included in this study. None of the patients developed any drug side effects or complications associated with ONB. With ONB, the median value of headache attack frequency dropped from 5 (range, 4-14) to 2 (range, 0-6) per month (p=0.001), the median value of pain duration dropped from 12 (range, 6-14) to 4 (range, 0-9) days (p<0.001), and the median value of VAS pain severity score dropped from 9 (range, 7-10) to 5 (range, 0-10) for the patients (p=0.001), compared with the pretreatment values. Conclusion: Bilateral greater and lesser ONBs are effective in the prophylaxis of episodic migraine without aura. ONB can be considered as a treatment option in patients with episodic migraine without aura who do not respond to conventional treatments (oral drugs) or do not accept conventional therapy.

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“…With the combined treatment of GON and SON blockade in a population of patients with episodic migraine, statistically significant reductions in both headache frequency as well as headache severity were seen compared with placebo. Patients with episodic migraine treated with combined GON and SON blocks experienced a reduction from 4.9 headache days per month down to 2.3 (a 53.1% reduction), compared with placebo experiencing only a reduction from 5.2 headache days per month down to 4.4 (a 15.1% reduction) [13].…”

Section: Supraorbital and Supratrochlear Nervesmentioning

confidence: 97%

Interventional Procedures in Episodic Migraine

Plato

Whitt

2020

Curr Pain Headache Rep

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Greater occipital and supraorbital nerve blockade for the preventive treatment of migraine: a single-blind, randomized, placebo-controlled study

Cited by 20 publications

References 37 publications

Peripheral Nerve Blockade and Botox Treatment in Chronic Migraine: A Comparative Study

Peripheral Nerve Blockade and Botox Treatment in Chronic Migraine: A Comparative Study

Effectiveness of Bilateral Greater and Lesser Occipital Nerve Blocks in the Prophylaxis of Episodic Migraine

Interventional Procedures in Episodic Migraine

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