Greater regional cortical gray matter thickness in obsessive-compulsive disorder

Narayan, Veena M.; Narr, Katherine L.; Phillips, Owen R.; Thompson, Paul M.; Toga, Arthur W.; Szeszko, Philip R.

doi:10.1097/wnr.0b013e3283112720

Cited by 29 publications

(25 citation statements)

References 24 publications

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“…It is compelling that although other SBA studies 21,23,25,26,30,31 found grey matter thickness to be affected in patients with OCD, our results did not show such alterations in this measure, but we did find partly similar alterations in other measures. However, when interpreting these divergent results one needs to be aware that previous studies presented rather heterogeneous results as well.…”

Section: Comparison With Surface-based Studiescontrasting

confidence: 52%

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Rus

Reeß

Wagner

et al. 2017

JPN

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IntroductionStudying the brain anatomic structure offers a promising approach to improve our understanding of neural functional alter ations often encountered in individuals with psychiatric disorders. In those with obsessive-compulsive disorder (OCD), a psychiatric disorder with a 2%-3% lifetime prevalence 1 that causes strong impairment of daily life, findings up to now show disruptions on a functional and a structural neural level, mainly in a network including cortico-striatothalamo-cortical (CSTC) areas. Overall, these findings are rather inconsistent and limited by confounding factors, such as differences in clinical characteristics of the study sample or varying methodological approaches.Meta-analytic reviews showed that cortical areas, mainly the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC) and parietofrontal regions, seem to be predominantly affected by grey matter volume deficits in patients with OCD, whereas the lenticular nuclei and thalamus were found to be characterized by increases in grey matter volume.2-4 A recent review article 5 confirmed these results and concluded that structural alterations in patients with OCD are widespread and occur most probably at a network level, with cortical tissue reductions and a tendency toward increases in grey matter volume of subcortical limbic areas. These subcortical tissue increases were also corroborated by a recent meta/mega-analysis of the ENIGMA OCD imaging consortium. 6 Additionally, this meta/mega-analysis showed that the neuroplasticity of specific areas depends on the age of the studied sample (i.e., smaller hippocampal but larger pallidum volumes were prominent in adults with OCD, whereas only larger thalamic volumes were specific for pediatric patients). Besides grey matter volume alterations in patients with OCD, significantly decreased grey matter thickness in partly overlapping areas (i.e., limbic, parietal and temporal areas) was also found in another recent mega-analysis. 7 It is Background: Mounting evidence indicates the presence of structural brain alterations in individuals with obsessive-compulsive disorder (OCD). Findings are, however, rather heterogeneous, which may be partly because of differences in methodological approaches or clinical sample characteristics. The aim of the present study was to analyze the whole brain cortical volume, surface area and thickness in a large sample of patients with OCD compared with age-and sex-matched healthy controls. Methods: We conducted whole brain surfacebased analyses of grey matter measures using the automated FreeSurfer software in patients with OCD and matched controls. Group analyses were performed and corrected for multiple testing using Monte Carlo simulations (p < 0.05). Altered brain regions and their average morphological values were associated to symptom severity and type (Yale-Brown Obsessive Compulsive Scale scores). Results:We included 75 patients and 75 controls in our analyses. Patients with OCD showed decreases in both volume and surface area compared with healthy ...

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Section: Comparison With Surface-based Studiescontrasting

confidence: 52%

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Rus

Reeß

Wagner

et al. 2017

JPN

View full text Add to dashboard Cite

show abstract

“…For example, Shin et al (Shin et al, 2007), examining OCD patients with long term treatment, have reported significant cortical thickness deficits in left inferior frontal, left middle frontal, left precentral, left superior temporal, left parahippocampal, left orbitofrontal and left lingual cortices. On the contrary, Narayan et al (Narayan et al, 2008) have demonstrated significantly increased thickness in right inferior frontal and posterior middle temporal cortices. In pediatric patients with OCD, reduced cortical thickness in left supramarginal gyrus has been observed in comparison with healthy controls (Fallucca et al, 2011).…”

Section: Introductionmentioning

confidence: 96%

Comprehensive evaluation of cortical structure abnormalities in drug-naïve, adult patients with obsessive-compulsive disorder: A surface-based morphometry study

Venkatasubramanian

Zutshi

Jindal

et al. 2012

Journal of Psychiatric Research

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“…49 Using fMRI, Remijnse and colleagues 6 reported reduced APFC activity in patients with OCD during affective switching. Using structural MRI, Narayan and colleagues 50 showed a thicker posterior temporal gyrus in patients with OCD. They argued that the structural abnormalities might underlie poor neuronal connectivity, which in turn could affect information integration and cognitive functions in patients with OCD.…”

Section: Abnormal Intrinsic Functional Connectivity In Ocdmentioning

confidence: 99%

Abnormal small-world architecture of top–down control networks in obsessive–compulsive disorder

Zhang

2011

J Psychiatry Neurosci

130

108

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disorder (OCD) is a common neuropsychiatric disorder that is characterized by recurrent intrusive thoughts, ideas or images and repetitive ritualistic behaviours. Although focal structural and functional abnormalities in specific brain regions have been widely studied in populations with OCD, changes in the functional relations among them remain poorly understood. This study examined OCD-related alterations in functional connectivity patterns in the brain's top-down control network. Methods: We applied resting-state functional magnetic resonance imaging to investigate the correlation patterns of intrinsic or spontaneous blood oxygen level-dependent signal fluctuations in 18 patients with OCD and 16 healthy controls. The brain control networks were first constructed by thresholding temporal correlation matrices of 39 brain regions associated with top-down control and then analyzed using graph theory-based approaches. Results: Compared with healthy controls, the patients with OCD showed decreased functional connectivity in the posterior temporal regions and increased connectivity in various control regions such as the cingulate, precuneus, thalamus and cerebellum. Furthermore, the brain's control networks in the healthy controls showed small-world architecture (high clustering coefficients and short path lengths), suggesting an optimal balance between modularized and distributed information processing. In contrast, the patients with OCD showed significantly higher local clustering, implying abnormal functional organization in the control network. Further analysis revealed that the changes in network properties occurred in regions of increased functional connectivity strength in patients with OCD. Limitations: The patient group in the present study was heterogeneous in terms of symptom clusters, and most of the patients with OCD were medicated. Conclusion: Our preliminary results suggest that the organizational patterns of intrinsic brain activity in the control networks are altered in patients with OCD and thus provide empirical evidence for aberrant functional connectivity in the large-scale brain systems in people with this disorder.

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Greater regional cortical gray matter thickness in obsessive-compulsive disorder

Cited by 29 publications

References 24 publications

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Comprehensive evaluation of cortical structure abnormalities in drug-naïve, adult patients with obsessive-compulsive disorder: A surface-based morphometry study

Abnormal small-world architecture of top–down control networks in obsessive–compulsive disorder

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