2023
DOI: 10.1111/acer.15039
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Greater resistance to footshock punishment in female C57BL/6J mice responding for ethanol

Abstract: Background: One characteristic of alcohol use disorder is compulsive drinking or drinking despite negative consequences. When quinine is used to model such aversionresistant drinking, female rodents typically are more resistant to punishment than males. Using an operant response task where C57BL/6J responded for ethanol mixed with quinine, we previously demonstrated that female mice tolerate higher concentrations of quinine in ethanol than males. Here, we aimed to determine whether this female vulnerability to… Show more

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Cited by 11 publications
(1 citation statement)
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“…Such consequences can include impaired relationships with friends and family, financial problems, poor work performance, legal trouble, exacerbation of existing physical/mental health conditions, and organ damage (Koob and Volkow, 2016;National Institute on Drug Abuse, 2023). Compulsive alcohol intake can be modeled in rodents by pairing aversive stimuli with alcohol consumption, such as delivering contingent footshock when alcohol is self-administered, or by adding the bitter tastant quinine to the alcohol solution (Seif et al, 2013;Randall et al, 2017;Fulenwider et al, 2019;Xie et al, 2019;Halladay et al, 2020;Sneddon et al, 2020;Katner et al, 2022;Sneddon et al, 2023a). If the animal continues to consume the alcohol despite such negative consequences, this is considered aversion-resistant, or inflexible, alcohol consumption (Hopf and Lesscher, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Such consequences can include impaired relationships with friends and family, financial problems, poor work performance, legal trouble, exacerbation of existing physical/mental health conditions, and organ damage (Koob and Volkow, 2016;National Institute on Drug Abuse, 2023). Compulsive alcohol intake can be modeled in rodents by pairing aversive stimuli with alcohol consumption, such as delivering contingent footshock when alcohol is self-administered, or by adding the bitter tastant quinine to the alcohol solution (Seif et al, 2013;Randall et al, 2017;Fulenwider et al, 2019;Xie et al, 2019;Halladay et al, 2020;Sneddon et al, 2020;Katner et al, 2022;Sneddon et al, 2023a). If the animal continues to consume the alcohol despite such negative consequences, this is considered aversion-resistant, or inflexible, alcohol consumption (Hopf and Lesscher, 2014).…”
Section: Introductionmentioning
confidence: 99%