Grecocyclines: New Angucyclines from <i>Streptomyces</i> sp. Acta 1362

Paululat, Thomas; Kulik, Andreas; Hausmann, Heike; Karagouni, Amalia D.; Zinecker, Heidi; Imhoff, Johannes F.; Fiedler, Hans‐Peter

doi:10.1002/ejoc.201000054

Cited by 17 publications

(17 citation statements)

References 12 publications

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“…Although the percentage of the antagonistic isolates screened was low, these results in comparison with previous observations [33, 56–58] support the hypothesis that the Greek Streptomyces isolates are multiactive and promising for their application in several biotechnological processes, including biocontrol of soil borne fungal pathogens. …”

Section: Resultssupporting

confidence: 82%

Streptomyces rocheiACTA1551, an Indigenous Greek Isolate Studied as a Potential Biocontrol Agent againstFusarium oxysporumf.sp.lycopersici

Kanini

Katsifas

Savvides

et al. 2013

BioMed Research International

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Many studies have shown that several Greek ecosystems inhabit very interesting bacteria with biotechnological properties. Therefore Streptomyces isolates from diverse Greek habitats were selected for their antifungal activity against the common phytopathogenic fungus Fusarium oxysporum. The isolate encoded ACTA1551, member of Streptomyces genus, could strongly suppress the fungal growth when examined in antagonistic bioassays in vitro. The isolate was found phylogenetically relative to Streptomyces rochei after analyzing its 16S rDNA sequence. The influence of different environmental conditions, such as medium composition, temperature, and pH on the expression of the antifungal activity was thoroughly examined. Streptomyces rochei ACTA1551 was able to protect tomato seeds from F. oxysporum infection in vivo while it was shown to promote the growth of tomato plants when the pathogen was absent. In an initial effort towards the elucidation of the biochemical and physiological nature of ACTA1551 antifungal activity, extracts from solid streptomycete cultures under antagonistic or/and not antagonistic conditions were concentrated and fractionated. The metabolites involved in the antagonistic action of the isolate showed to be more than one and produced independently of the presence of the pathogen. The above observations could support the application of Streptomyces rochei ACTA1551 as biocontrol agent against F. oxysporum.

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Section: Resultssupporting

confidence: 82%

Streptomyces rocheiACTA1551, an Indigenous Greek Isolate Studied as a Potential Biocontrol Agent againstFusarium oxysporumf.sp.lycopersici

Kanini

Katsifas

Savvides

et al. 2013

BioMed Research International

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“…; Paululat et al . ; ACTAPHARM‐Project, Final Report, 2005, http://cordis.europa. eu/library) led to the selection of six isolates, for further studies.…”

Section: Resultsmentioning

confidence: 99%

Greek indigenous streptomycetes as biocontrol agents against the soil-borne fungal plant pathogen Rhizoctonia solani

et al. 2013

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Aims: To examine the biocontrol potential of multiactive Greek indigenous Streptomyces isolates carrying antifungal activity against Rhizoctonia solani that causes damping-off symptoms on beans. Methods and Results: A total of 605 Streptomyces isolates originated from 12 diverse Greek habitats were screened for antifungal activity against R. solani DSM843. Almost one-third of the isolates proved to be antagonistic against the fungus. From the above isolates, six were selected due to their higher antifungal activity, identified by analysing their 16S rRNA gene sequence and studied further. The obtained data showed the following: firstly, the isolates ACTA1383 and ACTA1557 exhibited the highest antagonistic activity, and therefore, they were selected for in vivo experiments using bean seeds as target; secondly, in solid and liquid culture experiments under optimum antagonistic conditions, the medium extracts from the isolates OL80, ACTA1523, ACTA1551 and ACTA1522 suppressed the growth of the fungal mycelium, while extracts from ACTA 1383 and ACTA1557 did not show any activity. Conclusions: These results corresponded important indications for the utility of two Greek indigenous Streptomyces isolates (ACTA1557 and ACTA1383) for the protection of the bean crops from R. solani damping-off symptoms, while four of them (isolates OL80, ACTA1523, ACTA1551 and ACTA1522) seem to be promising producers of antifungal metabolites. Significance and Impact of the Study: This is the first study on the biocontrol of R. solani using multiactive Streptomyces isolates originated from ecophysiologically special Greek habitats. Our study provides basic information to further explore managing strategies to control this critical disease.

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“…Acta Pharmacologica Sinica npg cies) [127] . Compound 200 was reported to exhibit strong inhibitory activity with an IC 50 value of 0.52±0.17 μmol/L.…”

Section: Wwwnaturecom/aps Jiang Cs Et Almentioning

confidence: 99%

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

2012

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This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented.

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Grecocyclines: New Angucyclines from Streptomyces sp. Acta 1362

Cited by 17 publications

References 12 publications

Streptomyces rocheiACTA1551, an Indigenous Greek Isolate Studied as a Potential Biocontrol Agent againstFusarium oxysporumf.sp.lycopersici

Streptomyces rocheiACTA1551, an Indigenous Greek Isolate Studied as a Potential Biocontrol Agent againstFusarium oxysporumf.sp.lycopersici

Greek indigenous streptomycetes as biocontrol agents against the soil-borne fungal plant pathogen Rhizoctonia solani

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

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