Green algae Chlorococcum humicola-a new source of bioactive compounds with antimicrobial activity

Bhagavathy, S.; Sumathi, P.; Bell, I Jancy Sherene

doi:10.1016/s2221-1691(11)60111-1

Cited by 156 publications

(76 citation statements)

References 24 publications

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“…The fraction exhibiting antioxidant activity is characterized by yellow color in purple background as the delocalized spare electron of the DPPH molecule which give its deep violet color is transferred to hydrogen proton donated by the antioxidant compound(s) present in the extract leaving the yellow color of the picryl group (Molyneux, 2004). DPPH has been frequently used to screen the antioxidant activity of plant extracts (Jaime et al, 2005;Gu et al, 2009;Bhagavathy et al, 2011). These results suggest that the bioactive compounds exhibiting antimicrobial, α-amylase inhibition and antioxidant activities have different polarities.…”

Section: Tlc Bioautographymentioning

confidence: 99%

Evaluation of some biological activities of Trigonella hamosa aerial parts

Qari¹,

Fahmy²

2017

J. Pharmacognosy Phytother.

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The antimicrobial activity of T. hamosa aerial parts extract against Bacillus subtilis, Staphylococcus aureus, Enterococcus fecalis, Escherichia coli, Pseudomonas auregenosa, Candida albicans, Fusarium sp. and Aspergilus niger was evaluated by disc diffusion method. The minimum inhibitory concentrations (MICs) for susceptible test microorganisms were further determined. Also the antioxidant and α-amylase inhibition activities were investigated. The extract exhibited antimicrobial activity against C. albican, B. subtilis and E. fecalis; the MICs were 5.5, 7 and 8.5 mg/ml, respectively. Antioxidant and α-amylase inhibition activities of the extract were concentration dependent and the IC 50 values were 0.19 and 35 mg/ml, respectively. Thin layer chromatography (TLC) bioautography was used to detect the bioactive fractions of the extract. It revealed that three different fractions of different polarities exhibited antimicrobial, α-amylase inhibition and antioxidant activities. The toxicity of the extract to brine shrimp (Artemia salina) larvae was assessed and the LC 50 was found to be 2.3 mg/ml. This study suggests that the extract of T. hamosa aerial parts could be a source of bioactive compounds of different biological activities and is safe in terms of toxicity level.

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Section: Tlc Bioautographymentioning

confidence: 99%

Evaluation of some biological activities of Trigonella hamosa aerial parts

Qari¹,

Fahmy²

2017

J. Pharmacognosy Phytother.

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“…and defined palmitic (hexadecanoic) acid as the active agent. The phenolic compounds and main pigments (β-carotene and chlorophyll) of Chlorococcum himicola cells show a osedependent negative effect on microbial growth [28]. Water and ethanol extracts from ten green microalgae of the genera Chlorella, Desmococcus and Scenedesmus exhibit significant antibacterial (against Gram-positive and Gram-negative bacteria) and antitumor (against four tumor cell lines) activities [29].…”

Section: ) From Nostoc Flagelliformementioning

confidence: 99%

Biological activity of microalgae can be enhanced by manipulating the cultivation temperature and irradiance

Gacheva

Gigova

2014

Open Life Sciences

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The escalating levels of antibiotic resistance among pathogenic bacteria and the side effects of chemotherapeutic drugs in use forced the efforts of scientists to search for natural antimicrobial and anticancer substances with novel structures and unique mechanism of action. Focusing on bioproducts, recent trends in drug research have shown that microalgae (including the cyanobacteria) are promising organisms to furnish novel and safer biologically active compounds. Many microalgal metabolites have been found to possess potent antibacterial, antifungal, antiviral, anticancer and antiinflammatory activities, as well as antioxidant, enzyme inhibiting and immunostimulating properties. In this paper, the studies on the biological activity of microalgae associated with potential medical and pharmaceutical applications are briefly presented. Attention is focused on the impact of cultivation temperature, irradiance and growth stage on the biomass accumulation, activity and pathways of cell metabolism and the possibilities of using these variable factors to increase the diversity and quantity of biologically active substances synthesized by microalgae.

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“…Study of algae bioactive compound has grown in line with the isolation, purification, and characterization of the natural product. Researchers have been reported wide range activities of algae bioactive such as anti-inflammatory [13], antitrichomonal [14], antimicrobial [15], antioxidant [16], mitogenic [17] and many other potential activities.…”

Section: Introductionmentioning

confidence: 99%

Screening of proteins based on macro-algae from West Java coast in Indonesian marine as a potential anti-aging agent

Putri

Dewi

Handayani³

et al. 2018

AIP Conference Proceedings

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Abstract. Algae has been known as one of the potential marine bio-resources that have been used in many fields such as bio-energy, food, pharmaceutical and medical applications. Study of macro-algae or seaweed for medicine application, in particular, highlights to empower their ingredients as a promising antioxidant like anti-aging agent due to their diversity in biological activity. The tropical climate of Indonesia with the highest marine biodiversity puts this country an auspicious source of numerous alga species as a novel antioxidant source. A Sample of 29 species of macroalgae has been collected from Coast of Pari Island as a part of Seribu Islands, Indonesia. Screening and extracting of aqueous tropical marine alga protein as a potential source for an antioxidant agent has been done by using 2,2-diphenyl-1-picrylhydrazyl scavenging method, and protein contents have been determined by Lowry method. Sample number 26 of the phylum Rhodophyta have 9.00±0.03 % protein content, which is potential for nutritional food in form of nutraceutical. That sample demonstrated the maximum DPPH scavenging activity 79.27±1.81 %. Moreover, crude extract from another species from phylum Rhodophyta had the very lower IC50 (3.4333±0.29 mg/ml) followed by Chlorophyta species (7.1069±1.78 mg/ml). In general, this study found that algae from phylum Rhodophyta possess a high content of protein, high activity towards free radical. Nevertheless, algae acquire the lowest IC50 value not only dominated by Rhodophyta but also from phylum Chlorophyta. The conclusion of this study leads to empowering high antioxidant activity algae as an anti-aging agent, which can be used in pharmaceutical applications. Therefore, the next study should be concerned on the properties of the algae which has been known to be suitable for pharmaceutical fields.

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Green algae Chlorococcum humicola-a new source of bioactive compounds with antimicrobial activity

Cited by 156 publications

References 24 publications

Evaluation of some biological activities of Trigonella hamosa aerial parts

Evaluation of some biological activities of Trigonella hamosa aerial parts

Biological activity of microalgae can be enhanced by manipulating the cultivation temperature and irradiance

Screening of proteins based on macro-algae from West Java coast in Indonesian marine as a potential anti-aging agent

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