Green Alternatives as Antimicrobial Agents in Mitigating Periodontal Diseases: A Narrative Review

Mosaddad, Seyed Ali; Hussain, Ahmed; Tebyanian, Hamid

doi:10.3390/microorganisms11051269

Cited by 42 publications

(14 citation statements)

References 500 publications

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“…A remodeling process occurs at this stage, where the old and damaged bone is removed, and new bone is replaced. In addition to strengthening the interface between bone and implant, remodeling optimizes the mechanical properties of the implant itself 24,25,27,28 . It has been noted that osseointegration resembles fracture healing, in which lamellar bone replaces the original woven bone.…”

Section: Osseointegrationmentioning

confidence: 99%

Tissue engineering innovations to enhance osseointegration in immediate dental implant loading: A narrative review

Saleh Hasani Jebelli,

Yari,

Nikparto

et al. 2024

Cell Biochemistry & Function

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The demand for efficient and accelerated osseointegration in dental implantology has led to the exploration of innovative tissue engineering strategies. Immediate implant loading reduces treatment duration and necessitates robust osseointegration to ensure long‐term implant success. This review article discusses the current studies of tissue engineering innovations for enhancing osseointegration in immediate dental implant loading in the recent decade. Keywords “tissue engineering,” “osseointegration,” “immediate implant loading,” and related terms were systematically searched. The review highlights the potential of bioactive materials and growth factor delivery systems in promoting osteogenic activity and accelerating bone regeneration. The in vivo experiment demonstrates significantly improved osseointegration in the experimental group compared to traditional immediate loading techniques, as evidenced by histological analyses and biomechanical assessments. It is possible to revolutionize the treatment outcomes and patient satisfaction in dental implants by integrating bioactive materials and growth factors.

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Section: Osseointegrationmentioning

confidence: 99%

Tissue engineering innovations to enhance osseointegration in immediate dental implant loading: A narrative review

Saleh Hasani Jebelli,

Yari,

Nikparto

et al. 2024

Cell Biochemistry & Function

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“…Several accessible chemical agents can alter the oral microbiota, although these substances also have unfavorable symptoms, mainly caused by the imbalance of the oral/intestinal microbiota, such as vomiting, diarrhea, and tooth discoloration [ 129 ]. Precisely in light of this information, the natural phytochemicals generated from plants that have historically been used as medicines are categorized as prospective alternatives due to the ongoing quest for substitute products, ensuring greater compatibility of treatments [ 130 ]. A summary of the main virulence mechanisms of microorganisms most frequently involved in the development of oral diseases is reported in Table 1 .…”

Section: Oral Microbiome In the Development Of Oral Diseasesmentioning

confidence: 99%

Mediterranean diet: a potential player in the link between oral microbiome and oral diseases

Augimeri,

Caparello,

Caputo

et al. 2024

Journal of Oral Microbiology

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Background The oral microbiome is a complex and dynamic assemblage of microorganisms that colonize different sites of the oral cavity maintaining both oral and systemic health. Therefore, when its composition is altered, oral diseases occur. Among oral inflammatory pathologies, periodontal diseases affect the tissues surrounding the teeth, representing the main cause of tooth loss and one of the most important threats to the oral health. Lifestyle and eating habits influence the composition of the human oral microbiota and the development and progression of oral diseases. In this context, the Mediterranean Diet (MD) model, comprising both healthy dietary choices and lifestyle, is linked to the prevention of several metabolic and chronic-degenerative pathological processes, including oral diseases. Indeed, the MD is a plant-based diet, enriched of anti-inflammatory and antioxidant nutrients, which may induce beneficial effects against dental caries and periodontal diseases. Aim This review summarizes the role of the oral microbiome in the development of the oral diseases and the potential of MD in modulating the oral microbiome leading to implications for oral health. Conclusions The data collected highlight the need to promote the MD pattern along with the correct hygiene habits to prevent the development of oral diseases.

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“…Periodontitis is one of the most prevalent infectious diseases affecting oral health globally, and good oral health is crucial for enhancing life quality since it serves as the gateway to general health [ 15 , 16 ]. Increasing evidence suggests an independent link between periodontitis and systemic diseases such as diabetes and cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway

Wang,

Cai,

et al. 2024

Military Med Res

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Background Benign prostatic hyperplasia (BPH) is the most common disease in elderly men. There is increasing evidence that periodontitis increases the risk of BPH, but the specific mechanism remains unclear. This study aimed to explore the role and mechanism of the key periodontal pathogen Porphyromonas gingivalis (P. gingivalis) in the development of BPH. Methods The subgingival plaque (Sp) and prostatic fluid (Pf) of patients with BPH concurrent periodontitis were extracted and cultured for 16S rDNA sequencing. Ligature-induced periodontitis, testosterone-induced BPH and the composite models in rats were established. The P. gingivalis and its toxic factor P. gingivalis lipopolysaccharide (P.g-LPS) were injected into the ventral lobe of prostate in rats to simulate its colonization of prostate. P.g-LPS was used to construct the prostate cell infection model for mechanism exploration. Results P. gingivalis, Streptococcus oralis, Capnocytophaga ochracea and other oral pathogens were simultaneously detected in the Pf and Sp of patients with BPH concurrent periodontitis, and the average relative abundance of P. gingivalis was found to be the highest. P. gingivalis was detected in both Pf and Sp in 62.5% of patients. Simultaneous periodontitis and BPH synergistically aggravated prostate histological changes. P. gingivalis and P.g-LPS infection could induce obvious hyperplasia of the prostate epithelium and stroma (epithelial thickness was 2.97- and 3.08-fold that of control group, respectively), and increase of collagen fibrosis (3.81- and 5.02-fold that of control group, respectively). P. gingivalis infection promoted prostate cell proliferation, inhibited apoptosis, and upregulated the expression of inflammatory cytokines interleukin-6 (IL-6; 4.47-fold), interleukin-6 receptor-α (IL-6Rα; 5.74-fold) and glycoprotein 130 (gp130; 4.47-fold) in prostatic tissue. P.g-LPS could significantly inhibit cell apoptosis, promote mitosis and proliferation of cells. P.g-LPS activates the Akt pathway through IL-6/IL-6Rα/gp130 complex, which destroys the imbalance between proliferation and apoptosis of prostate cells, induces BPH. Conclusion P. gingivalis was abundant in the Pf of patients with BPH concurrent periodontitis. P. gingivalis infection can promote BPH, which may affect the progression of BPH via inflammation and the Akt signaling pathway.

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Green Alternatives as Antimicrobial Agents in Mitigating Periodontal Diseases: A Narrative Review

Cited by 42 publications

References 500 publications

Tissue engineering innovations to enhance osseointegration in immediate dental implant loading: A narrative review

Tissue engineering innovations to enhance osseointegration in immediate dental implant loading: A narrative review

Mediterranean diet: a potential player in the link between oral microbiome and oral diseases

P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway

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