Green and efficient extraction of four bioactive flavonoids from Pollen Typhae by ultrasound-assisted deep eutectic solvents extraction

Meng, Zhaorui; Zhao, Jing; Duan, Hongxia; Yuan-yuan, Guan; Zhao, Longshan

doi:10.1016/j.jpba.2018.08.048

Cited by 132 publications

(44 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, the combination of DES and UAE for the extraction of different flavonoid subclasses is most optimal when polyalcohol-based DES are used [47,48,[108][109][110][111]. For example, Mensur et al have optimized UAE-DES extraction of flavonoids in common buckwheat sprouts [47].…”

Section: Ultrasound-assisted Des/nades Extractions Of Bioactive Compomentioning

confidence: 99%

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

124

View full text Add to dashboard Cite

The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.

show abstract

Section: Ultrasound-assisted Des/nades Extractions Of Bioactive Compomentioning

confidence: 99%

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

124

View full text Add to dashboard Cite

show abstract

“…S3B, when water content in Bet/Gly was increased from 0 to 20%, the extraction efficiency of total coumarins was increased. The addition of water from 0 to 20% could greatly reduce the viscosity of DES significantly to allow the efficient extraction of polar components in Cortex Fraxini [8]. However, extraction efficiency of total coumarins was decreased as the water content in DES was further increased above 20%.…”

Section: Effect Of Water Content On Extraction Efficiencymentioning

confidence: 99%

“…Recently, DESs have become emerging new green solvents because of the advantages of biodegradability, low costs, and nontoxicity, and DESs have been widely applied in the fields of electrochemical materials, chemical synthesis and phytochemical extraction [5][6][7]. Reports show that DESs have now been used for the extraction of many kinds of chemical compounds, such as flavonoids [8][9][10] and phenolic acids [11][12], from various plants and traditional Chinese medicines. Cortex Fraxini comes from the dry bark of Fraxinus stylosa Lingelsh, and it is an important traditional Chinese herbal medicine used for the therapy of hyperuricemia and gout [13][14].…”

Section: Introductionmentioning

confidence: 99%

Green and enhanced extraction of coumarins from Cortex Fraxini by ultrasound‐assisted deep eutectic solvent extraction

Wang

et al. 2020

J of Separation Science

View full text Add to dashboard Cite

Green and enhanced extraction of bioactive ingredients from medicinal plants has become a hot research field, and deep eutectic solvents have been considered as a novel kind of sustainable solvents in the extraction process. In this study, hydrogen bond acceptor (choline chloride, etc.) and hydrogen bond donor (l‐malic acid, etc.) were used to prepare different kinds of deep eutectic solvents to extract coumarins from Cortex Fraxini. The extraction conditions, including the composition and moisture content of deep eutectic solvents, extraction time, and liquid‐solid ratio, were systematically optimized basing on the extraction yield of coumarins. To further investigate the extraction mechanism, Fourier transform infrared spectroscopy was performed, and the microstructures of Cortex Fraxini powders were observed before and after extraction using scanning electron microscope. Results showed that the novel ultrasound‐assisted extraction with conditions of deep eutectic solvent containing betaine/glycerin (1:3), aqueous solution (20%), solid‐liquid ratio (15 mg/mL), and extraction time (30 min) exhibited the best extraction yields for the four target coumarins and much better extraction efficiency than with conventional solvent extractions. This suggests that the new ultrasound‐assisted deep eutectic solvent extraction could be used as a green and high‐efficient approach for extraction of the main coumarins from Cortex Fraxini.

show abstract

“…Fu and et al have successfully used DESs as new extraction solvents to extract bioactive flavonoids from Equisetum palustre L . Zhao and co‐workers have applied ultrasound‐assisted DESs extraction method to extract four bioactive flavonoids from Pollen Typhae . Chen and his partners have used DESs‐mechanochemical extraction method to extract bioactive compounds such as flavonoids from plants.…”

Section: Introductionmentioning

confidence: 99%

Extraction and determination of bioactive flavonoids from Abelmoschus manihot (Linn.) Medicus flowers using deep eutectic solvents coupled with high‐performance liquid chromatography

Wan

Wang

Zhang

et al. 2019

J of Separation Science

View full text Add to dashboard Cite

These authors contributed equally to this work.A highly efficient and ecofriendly extraction method using deep eutectic solvents was developed to extract bioactive flavonoids from Abelmoschus manihot (Linn.) Medicus flowers. First, a series of deep eutectic solvents using choline chloride as hydrogen bond acceptor with different hydrogen bond donors was successfully synthesized.Then, the types of deep eutectic solvents and the extraction conditions for bioactive flavonoids (hyperoside, isoquercitrin, and myricetin) were optimized based on the flavonoids extraction efficiencies. The optimized deep eutectic solvent for hyperoside and isoquercitrin extraction was composed of choline chloride and acetic acid with a molar ratio of 1:2. The optimized deep eutectic solvent for myricetin extraction was composed of one mole of choline chloride and two moles of methacrylic acid. The optimal extraction conditions were set as: solid to solvent ratio, 35:1 (mg/mL); extraction time, 30 min; extraction temperature, 30 • C. Qualitative and quantitative analysis were performed using ultra high performance liquid chromatography with tandem mass spectrometry and high-performance liquid chromatography. And the extraction efficiencies of hyperoside, isoquercitrin, and myricetin under optimal extraction conditions were calculated as 11.57, 5.64, and 1.11 mg/g, much higher than those extracted by traditional extraction solvents. Therefore, the prepared deep eutectic solvents can be selected as alternative solvent to extract bioactive flavonoids. K E Y W O R D S bioactive flavonoids, deep eutectic solvents, ecofriendly extraction, high-performance liquid chromatography, traditional Chinese medicine 2044

show abstract

Green and efficient extraction of four bioactive flavonoids from Pollen Typhae by ultrasound-assisted deep eutectic solvents extraction

Cited by 132 publications

References 38 publications

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Green and enhanced extraction of coumarins from Cortex Fraxini by ultrasound‐assisted deep eutectic solvent extraction

Extraction and determination of bioactive flavonoids from Abelmoschus manihot (Linn.) Medicus flowers using deep eutectic solvents coupled with high‐performance liquid chromatography

Contact Info

Product

Resources

About