Green and facile synthesis of highly biocompatible carbon nanospheres and their pH-responsive delivery of doxorubicin to cancer cells

Liu, Xiaoli; Jiang, Hui; Ge, Wei; Wu, Chang-Yu; Chen, Donghua; Li, Qiwei; Chen, Yun; Wang, Xuemei

doi:10.1039/c4ra16359a

Cited by 19 publications

(9 citation statements)

References 55 publications

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“…The lattice spacings (calculated from SAED rings) are consistent with those of bulk magnetite (Joint Committee on Powder Diffraction Standards, JCPDS: 19‐0629) . The dynamic light scattering (DLS) results (Figure f) indicate that the as‐prepared C‐Fe 3 O 4 QDs possess a hydrodynamic diameter of about 28 nm in phosphate‐buffered saline (PBS) for one day with a polydispersity index of 0.149, being in agreement with the results of TEM characterization, as the hydrodynamic diameter is generally larger than geometric diameter owing to hydration effect . The C‐Fe 3 O 4 QDs still present a narrow size distribution with average diameter of about 38 nm after 30 d. Besides, the zeta potentials ( ζ ) of C‐Fe 3 O 4 QDs in neutral PBS after 1 and 30 d are −43.2 and −41.6 mV, respectively.…”

Section: Resultssupporting

confidence: 81%

Nitrogen‐Doped Carbon Quantum Dot Stabilized Magnetic Iron Oxide Nanoprobe for Fluorescence, Magnetic Resonance, and Computed Tomography Triple‐Modal In Vivo Bioimaging

Liu

Jiang

et al. 2016

Adv Funct Materials

Self Cite

125

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Multimodal imaging, which combines complementary information of two or more imaging modalities, offers huge advantages. In this paper, the synthesis, characterization, and application of superparamagnetic nitrogen-doped carbon-iron oxide hybrid quantum dots (C-Fe 3 O 4 QDs) is reported for triple-modal bioimaging through fluorescence/magnetic resonance/computed tomography (FL/MR/CT). Especially, C-Fe 3 O 4 QDs are synthesized by using poly (γ-glutamic acid) as a precursor and stabilizer via a green and facile one-pot hydrothermal approach. The as-prepared C-Fe 3 O 4 QDs exhibit excellent water dispersibility, wavelength-tunable FL property with high quantum yield of about 21.6%, good photostability, strong superparamagnetic property as well as favorable biocompatibility. Meanwhile, these C-Fe 3 O 4 QDs also show a transverse relaxivity value (r 2 ) of 154.10 mm −1 s −1 for T 2 -weighted MR imaging mode and an observable X-ray attenuation effect for CT imaging mode. Moreover, the in vivo bioimaging of tumor-bearing nude mice by combining FL, MR, and CT images further demonstrates that the as-prepared C-Fe 3 O 4 QDs can be readily and efficiently used in FL/MR/CT triple-modal tumor imaging. Hence, the new and facile one-pot synthesis strategy for preparing multifunctional C-Fe 3 O 4 QDs nanoprobes provides a convenient way for achieving an effective and versatile agent for tumorous bioimaging/or diagnostics.

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Section: Resultssupporting

confidence: 81%

Nitrogen‐Doped Carbon Quantum Dot Stabilized Magnetic Iron Oxide Nanoprobe for Fluorescence, Magnetic Resonance, and Computed Tomography Triple‐Modal In Vivo Bioimaging

Liu

Jiang

et al. 2016

Adv Funct Materials

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125

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“…When MCNs are used, the storage takes places thanks to the π-π staking interactions between the aromatic rings of DOX and the aromatic carbonaceous structure of the nanocarriers. They are non-covalent attractive interactions between aromatic molecules due to the sp 2 hybridization that can be disrupted when the pH drops, thus allowing the release of the drug [ 50 ].…”

Section: Host-guest Interactionsmentioning

confidence: 99%

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

2017

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The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. In this review, different approximations of pH-responsive systems are considered: those based on the use of the host-guest interactions between the nanocarriers and the drugs, those based on the hydrolysis of acid-labile bonds and those based on supramolecular structures acting as pore capping agents.

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“…As shown in Figure a, only DOX+HCPT in PBS exhibited the characteristic absorption peak for HCPT at ≈380 nm, while the main absorption peak of DOX disappeared. This implied that there was a possible existence of π–π interaction between DOX and HCPT (Figure c) . However, when DOX+HCPT were dispersed in DMF, the major absorptions of DOX at ≈500 nm and HCPT at ≈380 nm were both displayed (Figure b), which provided a possible evidence of the broken structure of the π–π interaction in DMF.…”

Section: Resultsmentioning

confidence: 96%

Codelivery of a π–π Stacked Dual Anticancer Drug Combination with Nanocarriers for Overcoming Multidrug Resistance and Tumor Metastasis

Xiao

Wang

Xiong

et al. 2016

Adv Funct Materials

135

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The multidrug resistance (MDR) of cancer cells is a major obstacle in cancer chemotherapy and very few strategies are available to overcome it. Here, a new strategy is developed to codeliver a π–π stacked dual anticancer drug combination with an actively targeted, pH‐ and reduction‐sensitive polymer micellar platform for combating multidrug resistance and tumor metastasis. In contrast to other methods, two traditional chemotherapeutics, doxorubicin (DOX) and 10‐hydroxycamptothecin with complex aromatic π–π conjugated structures, are integrated into one drug delivery system via a π–π stacking interaction, which enables the released drugs to evade the recognition of drug pumps due to a slight change in the drug's molecular structure. The micelles exhibit active targeting of DOX‐resistant human breast cancer MCF‐7 cells (MCF‐7/ADR) and have the ability to control the release of the drug in response to the microenvironmental stimuli of tumor cells. As a result, the codelivery of the π–π stacked dual anticancer drug combination displays high therapeutic efficacy in the MCF‐7/ADR tumor model and successfully prevents the lung metastasis of tumor cells. The mechanism underlying the reversal of MDR is investigated, and the results reveal that the synergistic effect of the π–π stacked dual drugs promotes mitochondria‐dependent apoptosis.

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Green and facile synthesis of highly biocompatible carbon nanospheres and their pH-responsive delivery of doxorubicin to cancer cells

Abstract: Carbon nanospheres with size below 71 nm are synthesized from bacterial cellulose nanofibers using a one-pot hydrothermal synthesis method.

Cited by 19 publications

References 55 publications

Nitrogen‐Doped Carbon Quantum Dot Stabilized Magnetic Iron Oxide Nanoprobe for Fluorescence, Magnetic Resonance, and Computed Tomography Triple‐Modal In Vivo Bioimaging

Nitrogen‐Doped Carbon Quantum Dot Stabilized Magnetic Iron Oxide Nanoprobe for Fluorescence, Magnetic Resonance, and Computed Tomography Triple‐Modal In Vivo Bioimaging

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

Codelivery of a π–π Stacked Dual Anticancer Drug Combination with Nanocarriers for Overcoming Multidrug Resistance and Tumor Metastasis

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