Green and facile synthesis of highly biocompatible graphene nanosheets and its application for cellular imaging and drug delivery

Liu, Kunping; Zhang, Jing Jing; Cheng, Fang; Zheng, Tingting; Wang, Chunming; Zhu, Jun‐Jie

doi:10.1039/c1jm10749f

Cited by 396 publications

(202 citation statements)

References 49 publications

Supporting

Mentioning

192

Contrasting

Order By: Relevance

“…Nanomedicines with high drug-loading content are usually prepared using processes with high drug-loading efficiency. [11][12][13][14] If the space capacity of the carrier material is low, it is difficult to get high drug-loading content, even if the preparation process of nanomedicines shows high drug-loading efficiency. [15][16][17] Taking into account most of the concepts investigated, high drug-loading efficiency may be necessary but not sufficient for a gain in high drug-loading content.…”

Section: Drug Loading Content (Weight [Wt]%)mentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

436

268

View full text Add to dashboard Cite

Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

show abstract

Section: Drug Loading Content (Weight [Wt]%)mentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

436

268

View full text Add to dashboard Cite

show abstract

“…On the other hand, the UV-vis spectrum of rGO (Figure 6b) demonstrates a broad band at 260 nm which can be attributed to the conjugated sp 2 carbon network in rGO and is a characteristic of rGO [51]. Since, no significance plasmon peak appears at 300 nm in the spectrum of rGO, suggesting the removal of oxygen groups and thereby confirming the successful reduction of GO to rGO [52]. Moreover, the characteristic peak of GO appears at 230 nm which is absent in the spectrum of rGO, thereby confirming the formation of rGO.…”

Section: Preprints (Wwwpreprintsorg) | Not Peer-reviewed | Posted: mentioning

confidence: 90%

Fabrication and Characterization of Electrospun PHA/Graphene Silver Nano-Composite Scaffold for Antibacterial Application

Mukheem¹,

Muthoosamy²,

Manickam³

et al. 2018

Preprint

View full text Add to dashboard Cite

Many wounds are unresponsive to current available treatment techniques and therefore there is an immense need to explore suitable materials including biomaterials, which are being considered as the crucial factor to accelerate the healing cascade. In this study, we fabricated polyhydroxyalkanoate based antibacterial mats via electrospun technique. One-pot green synthesized graphene decorated silver nanoparticles (GAg) were incorporated into the fibres of poly-3 hydroxybutarate-co-12 mol% hydroxyhexanoate (P3HB-co-12mol% HHx), a co-polymer of polyhydroxyalkanoate (PHA) family which is highly biocompatible, biodegradable and flexible in nature. The synthesised PHA/GAg biomaterial was characterized by field emission scanning electron microscopy (FESEM), elemental mapping, thermogravimetric analysis (TGA), UV-visible spectroscopy (UV-vis) and Fourier transform infrared spectroscopy (FTIR). In-vitro antibacterial analysis were performed to investigate the efficacy of PHA/GAg against gram positive Staphylococcus aureus (S.aureus) strain 12600 ATCC and gram negative Escherichia coli (E.coli) strain 8739 ATCC. The results indicated that the PHA/GAg demonstrated significant reduction of Staphylococcus aureus (S.aureus strain 12600 ATCC) and Escherichia coli (E.coli strain 8739 ATCC) as compared to bare PHA or PHA-rGO in 2 hours of time. The P value (P< 0.05) was obtained by using 2 sample T-test distribution.

show abstract

“…This red shift shows the reduction of GO and arises from the restoration of a π-conjugation network of reduced GO. In addition, the disappearance of the weak absorption peak at 300 nm vouches for the elimination of oxygen groups in reduced GO [23][24][25]. Figure 3C and D (inset) shows the UV-vis spectra and Tauc plot of the MgO-GO2 and MgO-GO3 sample produced by MgO doped-GO at 180°C and 210°C, respectively.…”

Section: Linear Optical Propertiesmentioning

confidence: 99%

Effect of temperature on the structural, linear, and nonlinear optical properties of MgO-doped graphene oxide nanocomposites

Kimiagar

Abrinaei

2017

Nanophotonics

View full text Add to dashboard Cite

Magnesium oxide (MgO)-graphene oxide (GO) nanocomposites were prepared by the hydrothermal method at different temperatures. The effect of growth temperature on the structural, linear, and nonlinear optical (NLO) parameters was investigated. The decoration of MgO on GO sheets was confirmed by X-ray diffraction, scanning electron microscopy, Fourier transform infrared, and UV-visible (UV-vis) spectroscopy analyses. The energy band-gaps of MgO-GO nanocomposites were calculated from UV-vis spectrum using Tauc plot. The NLO parameters of MgO-GO nanocomposites were calculated for the first time by the simple Z-scan technique with nanosecond Nd:YAG laser at 532 nm. The nonlinear absorption coefficient β and nonlinear refractive index n 2 for MgO-GO nanocomposites at the laser intensity of 1.1 × 10 8 W/cm 2 were measured to be in the order of 10 −7 cm/W and 10 −12 cm 2 /W, respectively. The third-order NLO susceptibility of MgO-GO nanocomposites was measured in the order of 10 −9 esu. The results showed that MgO-GO structures have negative nonlinearity as well as good nonlinear two-photon absorption at 532 nm. Furthermore, the NLO parameters increased by the enhancement of the growth temperature. As the investigation of new materials plays an important role in the advancement of optoelectronics, MgO-GO nanocomposites possess potential applications in NLO devices.

show abstract

Green and facile synthesis of highly biocompatible graphene nanosheets and its application for cellular imaging and drug delivery

Cited by 396 publications

References 49 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

Fabrication and Characterization of Electrospun PHA/Graphene Silver Nano-Composite Scaffold for Antibacterial Application

Effect of temperature on the structural, linear, and nonlinear optical properties of MgO-doped graphene oxide nanocomposites

Contact Info

Product

Resources

About