Green biotherapeutics: overcoming challenges in plant-based expression platforms

Jadhav, Rishabh Rajkumar; Khare, Deepa

doi:10.1007/s11816-024-00910-8

Plant Biotechnol Rep

2024

DOI: 10.1007/s11816-024-00910-8

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Green biotherapeutics: overcoming challenges in plant-based expression platforms

Rishabh Rajkumar Jadhav,

Deepa Khare

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2024

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Cited by 2 publications

References 163 publications

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Discovery and investigation of the truncation of the (GGGGS)n linker and its effect on the productivity of bispecific antibodies expressed in mammalian cells

Fang,

Chen,

Sun

et al. 2024

Bioprocess Biosyst Eng

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Discovery and investigation of the truncation of the (GGGGS)n linker and its effect on the productivity of bispecific antibodies expressed in mammalian cells

Fang,

Chen,

Sun

et al. 2024

Bioprocess Biosyst Eng

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Annatto (Bixa orellana)-Based Nanostructures for Biomedical Applications—A Systematic Review

Silva,

Martins,

dos Santos

et al. 2024

Pharmaceutics

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Plants are a source of valuable organic chemical compounds with complex structures rich in therapeutic activities. The encapsulation of compounds in nanostructured systems is an alternative to avoid limitations, such as instability and low solubility, and to promote therapeutic use. The objective of the present review was to summarize the data in the literature on the physicochemical characteristics, biomedical efficacy, and toxicity of nanostructures containing extracts and oils obtained from annatto (Bixa orellana). For this, searches were conducted in the CINAHL, LILACS, Embase, FSTA, MEDLINE, ProQuest, PubMed, ScienceDirect, Scopus, and Web of Science databases. Studies that carried out the development, physical-chemical characterization, and evaluation of therapeutic efficacy and/or in vitro, in vivo, or clinical toxicity of nanostructures containing extracts and oils derived from annatto were included in the review. Of the 708 articles found, nine met the inclusion criteria. The included studies developed different nanostructures (nanofibers, nanocochleates, chitosan, lipid, polymeric, and metallic nanoparticles). These nanostructures showed leishmanicidal, photoprotective, antioxidant, antimicrobial, and immunomodulatory efficacy, and tissue regeneration potential with no or low toxic effects in the tested models. Thus, the present work supports the nanostructuring of annatto extracts and oils as a relevant approach to the development of new technologies for biomedical applications.

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Green biotherapeutics: overcoming challenges in plant-based expression platforms

Cited by 2 publications

References 163 publications

Discovery and investigation of the truncation of the (GGGGS)n linker and its effect on the productivity of bispecific antibodies expressed in mammalian cells

Discovery and investigation of the truncation of the (GGGGS)n linker and its effect on the productivity of bispecific antibodies expressed in mammalian cells

Annatto (Bixa orellana)-Based Nanostructures for Biomedical Applications—A Systematic Review

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