Green Chemistry and Its Contribution to Industrial Biotechnology

Pleißner, Daniel; Kümmerer, Klaus

doi:10.1007/10_2018_73

Cited by 15 publications

(9 citation statements)

References 37 publications

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“…The inputs of natural origin have become an important source of renewable resources, based on green chemistry principles for application in the industrial sector. Among these, polysaccharides stand out because of their great versatility of [45,46]. In addition to the proposal to use native or derived polysaccharides as biologically active substances, several studies report the use of these in nanoformulations for biomedical applications.…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Are Structurally Modified Galactomannan Derivatives Biologically Active?

et al. 2021

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Galactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities of these polysaccharides have been extensively studied. The derivatives obtained by sulfation, complexation, and phosphorylation are the most studied biological properties in galactomannans. The derivatives obtained have shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, and antileishmanial. Considering the relevance of these studies, we aim to provide an overview of studies that apply galactomannan modification or derivatization strategies to improve their properties for applications in the biomedical area. We identified the success of most modified galactomannans for pharmacological purposes. However, some studies found loss of bioactivity of the original polysaccharide after chemical changes to its original structures.

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Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Are Structurally Modified Galactomannan Derivatives Biologically Active?

et al. 2021

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“… Developing chemicals or nanomaterials that have a high capacity to protect plants against O 3 -induced toxicity and degrade faster in the environment would reduce environmental/ecological risks. Targeting sustainable chemistry of plant protectants against O 3 -induced toxicity, and in particular via the building block of green chemistry [ 48 ], would help to comply with the goals of the United Nations 2030 Agenda for Sustainable Development. …”

Section: Introductionmentioning

confidence: 99%

“…Targeting sustainable chemistry of plant protectants against O 3 -induced toxicity, and in particular via the building block of green chemistry [ 48 ], would help to comply with the goals of the United Nations 2030 Agenda for Sustainable Development.…”

Section: Introductionmentioning

confidence: 99%

Exogenous application of chemicals for protecting plants against ambient ozone pollution: What should come next?

Saitanis

Agathokleous

2021

Current Opinion in Environmental Science & Health

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Elevated ground-level ozone (O 3 ) pollution can adversely affect plants and inhibit plant growth and productivity, threatening food security and ecological health. It is therefore essential to develop measures to protect plants against O 3 -induced adverse effects. Here we summarize the current status of phytoprotection against O 3 -induced adverse effects, and consider recent scientific and engineering advances, to provide a novel perspective for maximizing plant health while reducing environmental/ecological risks in an O 3 -polluted world. We suggest that nano-science and nano-technology can provide a new dimension in the protection of plants against O 3 -induced adverse effects, and recommend that new studies are based upon a green chemistry perspective.

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“…Our specific focus, thus, is on the design of enzymatic catalysis. Such design is of significance in a range of applications from addressing disease to shifting chemical industry toward more sustainable, waste minimizing and environmentally friendly production processes ( Pleissner and Kümmerer, 2020 ; Schrittwieser et al , 2018 ; Zimmerman et al , 2020 ). Chemical networks are central in this goal because almost all catalysis rests on a network-based mechanism, despite informal language often referring to a singular agent (the catalyst).…”

Section: Introductionmentioning

confidence: 99%

Graph transformation for enzymatic mechanisms

et al. 2021

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Motivation The design of enzymes is as challenging as it is consequential for making chemical synthesis in medical and industrial applications more efficient, cost-effective and environmentally friendly. While several aspects of this complex problem are computationally assisted, the drafting of catalytic mechanisms, i.e. the specification of the chemical steps—and hence intermediate states—that the enzyme is meant to implement, is largely left to human expertise. The ability to capture specific chemistries of multistep catalysis in a fashion that enables its computational construction and design is therefore highly desirable and would equally impact the elucidation of existing enzymatic reactions whose mechanisms are unknown. Results We use the mathematical framework of graph transformation to express the distinction between rules and reactions in chemistry. We derive about 1000 rules for amino acid side chain chemistry from the M-CSA database, a curated repository of enzymatic mechanisms. Using graph transformation, we are able to propose hundreds of hypothetical catalytic mechanisms for a large number of unrelated reactions in the Rhea database. We analyze these mechanisms to find that they combine in chemically sound fashion individual steps from a variety of known multistep mechanisms, showing that plausible novel mechanisms for catalysis can be constructed computationally. Availability and implementation The source code of the initial prototype of our approach is available at https://github.com/Nojgaard/mechsearch Supplementary information Supplementary data are available at Bioinformatics online.

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Green Chemistry and Its Contribution to Industrial Biotechnology

Cited by 15 publications

References 37 publications

Are Structurally Modified Galactomannan Derivatives Biologically Active?

Are Structurally Modified Galactomannan Derivatives Biologically Active?

Exogenous application of chemicals for protecting plants against ambient ozone pollution: What should come next?

Graph transformation for enzymatic mechanisms

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