Green chemistry and photochemistry were born at the same time

Albini, Angelo; Fagnoni, Maurizio

doi:10.1039/b309592d

Cited by 274 publications

(153 citation statements)

References 37 publications

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“…Thus, the photon is the green reagent par excellence, or at least this is what photochemistry practitioners think. In order that this concept is generally accepted, suitable tests of its viability must be made [2,6].…”

Section: Photochemistry and Green Chemistrymentioning

confidence: 99%

“…The first unambiguous statement of the concept and the aim of green chemistry are more than 100 years old and refer to Giacomo Ciamician [1,2]. At the turn of the 19 th century, this great scientist reasoned that man was now able to prepare the compounds that nature made, and that the difference was not in the structure of such products, but in the way in which they were formed.…”

Section: Introductionmentioning

confidence: 99%

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Photochemistry in synthesis: Where, when, and why

Protti

Dondi

Fagnoni

et al. 2007

Pure and Applied Chemistry

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A series of photochemical reactions are assessed under the environmental aspect by using Eissen and Metzger's EATOS (environmental assessment tool for organic syntheses) method and are compared with strictly analogous thermal processes. These include C-C bond-forming reactions (arylation and alkylation) and selective oxidation and reduction reactions. In most cases, the photochemical method is experimentally simpler and less expensive than the thermal alternative. A disadvantage is that photochemical reactions are carried out in rather dilute solution, and this factor gives by far the main contribution to the assessment. However, if the solvent is recovered, the photochemical reaction is more environmentfriendly.

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Section: Photochemistry and Green Chemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photochemistry in synthesis: Where, when, and why

Protti

Dondi

Fagnoni

et al. 2007

Pure and Applied Chemistry

Self Cite

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show abstract

“…Although the past several decades have witnessed tremendous successes of transition-metal catalysis in organic chemistry, the difficulty associated with metal residues has led to concerns in, for example, the pharmaceutical and electronic industries. Transition-metal (depleting and precarious) 3,4 -free couplings in water (a greener solvent) 5 enabled by photoenergy (a cleaner energy input) 6 provide great opportunities towards more sustainable synthetic chemistry.…”

mentioning

confidence: 99%

Empowering a transition-metal-free coupling between alkyne and alkyl iodide with light in water

Liu

2015

Nat Commun

137

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Methods to assemble alkynes are essential for synthesizing fine chemicals, pharmaceuticals and polymeric photo-/electronic materials. Using light as a clean energy form and water as a green solvent has the potential to make synthetic chemistry more environmentally friendly. Here we present a transition-metal-free coupling protocol between aryl alkyne and alkyl iodide enabled by photoenergy in water. Under ultraviolet irradiation and in basic aqueous media, aryl alkynes efficiently couple with a wide range of alkyl iodides including primary, secondary and tertiary ones under mild conditions. A tentative mechanism for the coupling is also proposed.

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“…Photochemical reactions carried out with sunlight are particularly interesting in the context of green chemistry due to substrate activation often occurs without additional reagents, which diminishes formation of by products, and the renewable nature of the energy source [2,3]. Over the last few decades, the growing demand for environmentally friendly technologies has attracted rising attention in synthetic organic photochemistry [4].…”

Section: Introductionmentioning

confidence: 99%