Green Chemistry and Synthesis of Anticancer Molecule

Abstract

Green chemistry is a modern area of chemistry merged with chemical engineering methods. It highlighted the synthesis of molecules in a manner of using environment-friendly chemical reagents with low waste material for enhancing environmental performance which reduce the formation of hazard substances. Modern researches are trying to reduce the risk of human kind health and the environment of our world by doing magnificent work in the field of green chemistry. In the pharmaceutical field, green chemistry works very well with the formation of many drugs and it utilizes non-hazards, reproducible and environment-friendly solvents with low time and money costs by using catalyst, microwave, ultrasonic, solid phase and solvent-free synthesis. Until now, scientist has synthesized many anticancer molecules by using these modern green chemistry techniques. These compounds showed significant anticancer activities against many human cancer cell lines. In this chapter, we will cover different views and the recently published literature to summarize the role of green chemistry in the synthesis of anticancer compounds.

Advancement in Biopolymer Assisted Cancer Theranostics

“…Nanomaterials are much more efficient than chemotherapeutics in delivery to the target site . However, further research is being conducted to improve the penetration of large sized NPs through introducing cross-linking methods. − Ju et al reported the formulation of a nanogel containing a polyelectrolyte core cross-linkage comprised of N -lysinal- N ′-succinyl chitosan and poly­( N -isopropylacrylamide) along with a cross-linked shell of bovine serum albumin which showed swelling in an acidic environment followed by shrinking under neutral conditions . This swelling was responsible for quickly releasing the encapsulated chemotherapeutic agent into the cancer cells for effective cytotoxicity.…”

A Systematic Review of Biosynthesized Metallic Nanoparticles as a Promising Anti-Cancer-Strategy

“…From all the approaches of NPs synthesis, green synthesis approach is considered the most economic, sustainable, reliable and eco-friendly [ 37 ]. This approach of NPs synthesis does not require toxic chemicals, high temperature, high pressure and does not cause harm to human health and the environment [ 38 ].…”

Dioxygen Activation by Laccases: Green Chemistry for Fine Chemical Synthesis

“…In the biopharma sector, unlike the traditional pharmaceutical industry, green chemistry focuses on the design of facile, eco-friendly, cost-efficient, sustainable, and high yielding methods for the synthesis of new drugs that are safe for human health and environment. For the synthesis of anticancer molecules, for example, green methods were developed based on physicochemical procedures as microwave irradiation, ultrasonic irradiation, Claisen-Schmidt condensation, green solvents, and high temperatures (from 80 to 130 • C) to obtain product yields of 70% and 96% [28]. However, the green physicochemical procedures still require special equipment, multiple chemicals consumption, and large quantities of energy.…”