Green Chemistry Approach to Fast and Highly Efficient One-Pot Synthesis of Bis-Isoxazolyl-1,2,5,6-Tetrahydro Pyridine-3-Carboxylates

Abstract

<p class="MsoNormal"> <span lang="EN-US">The synthesis of the bis-isoxazolyl-1,2,5,6-tetrahydro pyridine-3-carboxylates is achieved in high yield without the production of toxic waste products by using room temperature ionic liquid (RTILs) triethyl ammonium acetate (TEAA). The RTIL TEAA played the dual role of efficient green solvent as well as recyclable catalyst.</span><span lang="EN-US"><o:p></o:p></span> </p

One‐Pot Pseudo Five Component Synthesis of Biologically Relevant 1,2,6‐Triaryl‐4‐arylamino‐piperidine‐3‐ene‐3‐ carboxylates: A Decade Update

“…Rajanarendar et al . synthesized a series of bis ‐isoxazolyl‐1,2,5,6‐tetrahydro pyridine‐3‐carboxylate starting from two equivalents of aromatic aldehydes, two equivalents of 4‐amino‐3‐methyl‐5‐styrylisoxazole and one equivalent of ethyl acetoacetate in ionic liquid triethyl ammonium acetate (TEAA) without adding any extra catalyst at room temperature (Scheme ).…”

Recent developments in multicomponent synthesis of structurally diversified tetrahydropyridines

“…A room temperature ionic liquid (RTILs) triethyl ammonium acetate (TEAA) was employed to develop a highly efficient methodology for the synthesis of bis-isoxazolyl-1,2,5,6tetrahydro pyridine-3-carboxylates 12 by using isoxazole amine 9, ethyl acetoacetate 10 and aldehyde 11 along with TEAA ionic liquid, in which ionic liquid play dual role of solvent and recyclable catalyst (Scheme 2). 27 High yields, reduction in reaction time, avoids the usage of hazardous organic solvents, no byproducts formation and use of room temperature ionic liquid were made this method a greener approach.…”