Green Chemistry Preservation and Extraction of Biospecimens for Multi-omic Analyses

Tikunov, Andrey P.; Tipton, Jeremiah D.; Garrett, Timothy J.; Shinde, Sachi V; Kim, Hee Jin; Gerber, David A.; Herring, Laura E.; Graves, Lee M.; Macdonald, Jeffrey M.

doi:10.1007/978-1-0716-1811-0_17

Cited by 1 publication

(2 citation statements)

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“…Analytical studies should aim to develop selective extraction methods to promote green chemistry. 98 , 99 , 100 This shift has been reflected in the trends observed for 2022, where the Folch and Matyash protocols competed to be the most popular extractions for cells, tissues, serum, and plasma (Figure 2 ). Interestingly, a new monophasic extraction protocol has been developed in 2022 by Fu et al.…”

Section: In Review: Materials and Methodsmentioning

confidence: 96%

“…With or without the automation of the sample preparation, it is crucial that solvent selection is not only driven by chemistry but also by eco‐friendliness. Analytical studies should aim to develop selective extraction methods to promote green chemistry 98–100 . This shift has been reflected in the trends observed for 2022, where the Folch and Matyash protocols competed to be the most popular extractions for cells, tissues, serum, and plasma (Figure 2).…”

Section: In Review: Materials and Methodsmentioning

confidence: 99%

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Chewing the fat: How lipidomics is changing our understanding of human health and disease in 2022

Géhin

Fowler

Trivedi

2023

Analytical Science Advances

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Lipids are biological molecules that play vital roles in all living organisms. They perform many cellular functions, such as 1) forming cellular and subcellular membranes, 2) storing and using energy, and 3) serving as chemical messengers during intra‐ and inter‐cellular signal transduction. The large‐scale study of the pathways and networks of cellular lipids in biological systems is called “lipidomics” and is one of the fastest‐growing omics technologies of the last two decades. With state‐of‐the‐art mass spectrometry instrumentation and sophisticated data handling, clinical studies show how human lipid composition changes in health and disease, thereby making it a valuable medium to collect for clinical applications, such as disease diagnostics, therapeutic decision‐making, and drug development. This review gives a comprehensive overview of current workflows used in clinical research, from sample collection and preparation to data and clinical interpretations. This is followed by an appraisal of applications in 2022 and a perspective on the exciting future of clinical lipidomics.

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Section: In Review: Materials and Methodsmentioning

confidence: 96%

Section: In Review: Materials and Methodsmentioning

confidence: 99%