Green coffee extract attenuates Parkinson’s-related behaviors in animal models

Molska, Graziella Rigueira; Paula-Freire, Lyvia Izaura Gomes; Sakalem, Marna Eliana; Köhn, Daniele Oliveira; Negri, Giuseppina; Carlini, E. A.; Mendes, Fúlvio Rieli

doi:10.1590/0001-3765202120210481

Cited by 6 publications

(3 citation statements)

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“…Several adenosinergic antagonists, including caffeine, have shown effect at this animal model [35][36]. In a previous study, we demonstrated that a green coffee extract, rich in chlorogenic acid, was able to inhibit the haloperidol-induced catalepsy [17].…”

Section: Discussionmentioning

confidence: 79%

“…Cataleptic status was evaluated after 45 minutes of the haloperidol administration. Each mouse was placed with both front paws over bars suspended 5 cm from the surface and the time to remove the paws was counted, up to 10 consecutive trials or up to 10 minutes [17]. The catalepsy score was obtained dividing catalepsy total time (seconds) by the number of times the mice left the bar.…”

Section: Haloperidol-induced Catalepsymentioning

confidence: 99%

“…Rotational behavior was accessed on the 14 th day after surgery with the administration of apomorphine (0.1 mg/kg, sc) and on the 15 th day, after administration of methamphetamine (2.5 mg/kg, ip). The number of complete (360°) contralateral and ipsilateral rotations was counted by a blind observer for one hour after the administration of each drug [17]. The treatment with coffee on the test days was made after the behavioral observation and the animals were euthanized approximately 24h after the last treatment.…”

Section: Rotational Behaviormentioning

confidence: 99%

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Anticholinesterase and Pro-dopaminergic Effects of Instant Coffee

Köhn¹,

Molska²,

Paula-Freire³

et al. 2022

Preprint

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Epidemiologic studies suggest an inverse correlation between coffee consumption and the occurrence of neurodegenerative diseases, but the role of caffeine and roasting degree are still matter of debate. The objective of this work was to evaluate the effects of caffeinated (light, medium, and dark roast) and decaffeinated instant coffee samples in acetylcholinesterase inhibition and antioxidant assays, as well as in animal models of Parkinson’s disease. Caffeinated coffees inhibited the acetylcholinesterase in much smaller concentrations than decaffeinated coffee. All coffee samples showed antioxidant capacity without relation with the caffeine content. Dopaminergic-like activity in the haloperidol-induced catalepsy test was observed with caffeinated coffee, but not in the decaffeinated sample. The medium roast coffee reduced the number of rotations of rats after methamphetamine administration on the 6-hydroxydopamine unilateral lesion of the medial forebrain bundle. However, the coffee treatment did not avoid the loss of dopaminergic neurons on substantia nigra pars compact and only the smallest dose of coffee was able to avoid the decrease of dopamine levels in the lesioned side of the striatum. Altogether, these results suggest that coffee exerts moderate pro-cholinergic and pro-dopaminergic effects and caffeine seems to be the main responsible for these effects.

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Section: Discussionmentioning

confidence: 79%

Section: Haloperidol-induced Catalepsymentioning

confidence: 99%

Section: Rotational Behaviormentioning

confidence: 99%

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