Green design alternatives for isopropanol recovery in the celecoxib process

Slater, C. Stewart; Savelski, Mariano J.; Hounsell, Gregory; Pilipauskas, Daniel; Urbanski, Frank J.

doi:10.1007/s10098-011-0433-6

Cited by 21 publications

(18 citation statements)

References 9 publications

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“…Lowercase x and y are used for PV or V·P to distinguish them from the VLE uppercase variables X and Y. The ratio of permeate mass fractions is equivalent to the ratio of mass fluxes and, as shown in Eqn (6), the ratio of permeate mole fractions is equal to the ratio of molar fluxes. Thus, given the feed composition, the separation factor can be calculated from the permeate water purity and vice versa.…”

Section: Pv and V·p Membrane Performance Descriptorsmentioning

confidence: 99%

“…The life cycle environmental impact of using organic solvents can be reduced by recovering and reusing the solvents, avoiding the impacts associated with producing the virgin solvents and disposing of the spent solvents. [1][2][3][4][5][6][7] Solvent reuse/reprocessing requires separation technologies to recover and purify the solvents from mixtures with other materials they encounter in industrial applications. For hydrophilic solvents, and even some solvents not typically considered 'water loving', water is often a contaminant that must be removed prior to reuse.…”

Section: Introductionmentioning

confidence: 99%

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Review of pervaporation and vapor permeation process factors affecting the removal of water from industrial solvents

Vane

2019

J of Chemical Tech & Biotech

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A recent review article (Journal of Chemical Technology & Biotechnology 94: 343-365 (2019)) identified several commerciallyavailable permselective materials for drying organic solvents with pervaporation (PV) and vapor permeation (V·P) separation processes. The membrane materials included polymeric and inorganic substances exhibiting a range in the performance characteristics: water permeance, water/solvent selectivity, and maximum use temperature. This article provides an overview of the factors affecting the design of PV/V·P processes utilizing these membranes to remove water from common organic solvents. Properties of the specific membrane and of the solvent substantially affect the PV/V·P separation. Equally important is the impact of operating parameters on the overall separation. To study these impacts, simplified process performance equations and detailed spreadsheet calculations were developed for single-pass and recirculating batch PV systems and for single-pass V·P systems. Estimates of membrane area, permeate concentration, solvent recovery, permeate condenser temperatures, and heating requirements were calculated. Process variables included: solvent type, water permeance, water/solvent selectivity, initial and final water concentrations, operating temperature (PV) or feed pressure (V·P), temperature drop due to evaporation (PV) or feed-side pressure drop (V·P), and permeate pressure. The target solvents considered were: acetonitrile, 1-butanol, N,N-dimethyl formamide, ethanol, methanol, methyl isobutyl ketone, methyl tert-butyl ether, tetrahydrofuran, acetone, and 2-propanol.

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Section: Pv and V·p Membrane Performance Descriptorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Review of pervaporation and vapor permeation process factors affecting the removal of water from industrial solvents

Vane

2019

J of Chemical Tech & Biotech

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“…To simplify the analysis, this list was collated and reduced into generalized categories. Therefore, the LCIs and LCEs reported in this study are in terms of annualized quantities (kg/yr) for CO 2 , CO, CH 4 , NO x , non‐methane volatile organic compounds (NMVOC), particulates, and SO 2 emissions released into the air, and VOC emissions released into the water environment; as consistent with previous methods used for the chemical and pharmaceutical industries 55‐58 . Overall, once the life cycle emissions of the base case and water recovery alternative have been obtained, the amount of avoided emissions were then estimated by getting the difference between the two cases.…”

Section: Methodsmentioning

confidence: 70%

Environmental and process assessment of a vibratory nanofiltration system for the recovery of water from soluble coffee manufacturing waste

Wisniewski

Laurio

Slater

et al. 2020

Env Prog and Sustain Energy

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A case study has been conducted for the recovery of water from complex wastewater at a soluble coffee manufacturing factory. The study has evaluated separation methods for process intervention based on environmental and economic assessments. A novel vibratory field membrane separation was evaluated at the laboratory scale using actual factory wastewater, and was scaled‐up using appropriate design protocols. The recovery of water from an intermediate waste stream proved the most effective, both environmentally and economically. The proposed full‐scale vibratory membrane process recovers 378,541 L of water per day that meets specifications for reuse in the factory cooling tower. The proposed design reduced the daily well freshwater withdrawn by 21% and the amount of wastewater discharged from the factory by 28.5%. Annual operating costs were reduced by 22.5% and total life cycle emissions were reduced by 27.8%. These reductions are mainly the result of the reduced volume of wastewater discharged from the factory and the reduced energy requirement of the on‐site pretreatment processes. Economic assessment showed a net present value after 10 years is $181,100, while the payback time is under 3 years. Overall, the proposed vibratory membrane process used for water recovery presents favorable economics, and significant environmental emission reduction.

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“… Case-specific studies. No process design of the solvent recovery options and alternatives Slater et al., (2012a) Coupled distillation with pervaporation and demonstrated that over 92% of emissions associated with the solvent recovery and incineration can be reduced when recovering isopropyl alcohol (IPA) from water Process and solvent specific. Only binary mixture was considered; no multi-component analysis Slater et al., (2012b) Coupled a constant volume distillation with pervaporation and demonstrated the recovery of tetrahydrofuran (THF) from water, as compared to azeotropic distillation.…”

Section: Solvent Recovery In Practicementioning

confidence: 99%

Systems level roadmap for solvent recovery and reuse in industries

2021

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Summary Recovering waste solvent for reuse presents an excellent alternative to improving the greenness of industrial processes. Implementing solvent recovery practices in the chemical industry is necessary, given the increasing focus on sustainability to promote a circular economy. However, the systematic design of recovery processes is a daunting task due to the complexities associated with waste stream composition, techno-economic analysis, and environmental assessment. Furthermore, the challenges to satisfy the desired product specifications, particularly in pharmaceuticals and specialty chemical industries, may also deter solvent recovery and reuse practices. To this end, this review presents a systems-level approach including various methodologies that can be implemented to design and evaluate efficient solvent recovery pathways.

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Green design alternatives for isopropanol recovery in the celecoxib process

Cited by 21 publications

References 9 publications

Review of pervaporation and vapor permeation process factors affecting the removal of water from industrial solvents

Review of pervaporation and vapor permeation process factors affecting the removal of water from industrial solvents

Environmental and process assessment of a vibratory nanofiltration system for the recovery of water from soluble coffee manufacturing waste

Systems level roadmap for solvent recovery and reuse in industries

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