Green engineering of TMC-CMS nanoparticles decorated graphene sheets for targeting M. tuberculosis

Advances in the fabrication of potential nanomaterials for diagnosis and effective treatment of tuberculosis

“…53 In contrast, TC NPs with graphene nanosystems have been exploited to be applied safely as an excellent anti-TB drug. 52 From previous literature and some relevant studies, all the reported data confirmed the promising effects of NPs, which efficiently enhanced further in vivo studies. It is noteworthy that the data tabulated revealed a significant efficiency of most fabricated NPs, particularly those small particles whose size ranged from 20 to 100 nm.…”

“…For instance, a highly biocompatible graphene layer was engineered and decorated with N , N , N -trimethyl chitosan (TMC)/carboxymethyl starch (CMS) interpenetrating polymer networks (IPN) via a green and a one ultrasonic pot strategy. 52 TEM analysis revealed a uniform distribution of TMC-CMS hydrogel NPs on graphene surfaces with a small particle size of 22 nm, which was roughly compared to the pure NPs formed at 30 nm. The inhibition activity of the synthetic nanocomposite was evaluated against different M. tuberculosis pathogens with MIC values of 0.98, 3.9, and 7.81 μg mL −1 for sensitive, MDR, and XDR compared to the bare TCNPs (7.81, 31.25, and >125 μg mL −1 ) and the isoniazid drug (0.24, 0, and 0 μg mL −1 ), respectively.…”

Straightforward Way to Provide Antibacterial Properties to Healthcare Textiles through N-2-Hydroxypropyltrimethylammonium Chloride Chitosan Crosslinking

“…Although the exact mode of action is not elucidated in detail, the bactericidal action of quaternary ammonium functions is well established in the literature. Chitosan quaternized derivatives are known to be highly antibacterial , regardless of the pH. This is why we chose this derivatization synthesis strategy, which has the dual effect of increasing the aqueous solubility of chitosan and increasing positively the amino group amount.…”

Construction, molecular docking simulation and evaluation of electrochemical properties of polymeric nanospheres comprising novel synthesized monomer via green microemulsion polymerization

“…Herein, the heterocyclic heterocycles were optimized with the Gaussian 09 program 56,60,70 via the DFT/B3LYP/6-31 (G) basis set. Furthermore, the physical features used in the determination of monomers (CHAA) (4), poly (MMA/DMAEMA/AA) and poly (CHAA/MMA/ DMAEMA/AA), respectively, regarding (σ) absolute softness, 71 (χ) electronegativities, 72 (ΔN max ) electronic charge, 73 (η) absolute hardness, (ω) 74 global electrophilicity, 75 (S) global softness, 76 and (Pi) chemical potential, 77 from the equations [3][4][5][6][7][8][9][10] are scheduled in Table 2 and Figure 6.…”

“…Recent advances in nanoparticle technology have substantially increased the effectiveness of polymers. Polymeric nanoparticle systems have unique properties physio‐chemically and technologically, which make them an excellent choice for smart applications 1–6 such as preserving archeological artifacts, 7 creating bioactive materials, 8–12 packaging food, 13 treating water, 14 creating biosensors, 15 manufacturing electronics, 16 and storing energy 17 . These polymeric nanoparticles are nontoxic, biodegradable, biocompatible, have an expansive surface area, thermodynamic stability and free movement 17,18 .…”