Green extraction of polyphenolic-polysaccharide conjugates from Pseuderanthemum palatiferum (Nees) Radlk.: Chemical profile and anticoagulant activity

Ho, Truc Cong; Kiddane, Anley Teferra; Sivagnanam, Saravana Periaswamy; Park, Jin-Seok; Cho, Yeon-Jin; Getachew, Adane Tilahun; Nguyen, Thanh-Tuyen Thi; Kim, Gun‐Do; Chun, Byung‐Soo

doi:10.1016/j.ijbiomac.2020.04.113

Cited by 16 publications

(6 citation statements)

References 45 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared to the conventional extraction with citric acid, SBWE can obtain higher pectin yield, higher galacturonic acid content and a higher degree of methyl esterification. Similarly, Chun et al [ 158 ] and Goosen et al [ 169 ] carried out SBWE and compared it with conventional extraction using 0.05 M HCl. They all found that SBWE efficiency was significantly higher compared to the conventional methods.…”

Section: Compounds Extracted By Subcritical Watermentioning

confidence: 99%

Subcritical Water Extraction of Natural Products

et al. 2021

View full text Add to dashboard Cite

Subcritical water refers to high-temperature and high-pressure water. A unique and useful characteristic of subcritical water is that its polarity can be dramatically decreased with increasing temperature. Therefore, subcritical water can behave similar to methanol or ethanol. This makes subcritical water a green extraction fluid used for a variety of organic species. This review focuses on the subcritical water extraction (SBWE) of natural products. The extracted materials include medicinal and seasoning herbs, vegetables, fruits, food by-products, algae, shrubs, tea leaves, grains, and seeds. A wide range of natural products such as alkaloids, carbohydrates, essential oil, flavonoids, glycosides, lignans, organic acids, polyphenolics, quinones, steroids, and terpenes have been extracted using subcritical water. Various SBWE systems and their advantages and drawbacks have also been discussed in this review. In addition, we have reviewed co-solvents including ethanol, methanol, salts, and ionic liquids used to assist SBWE. Other extraction techniques such as microwave and sonication combined with SBWE are also covered in this review. It is very clear that temperature has the most significant effect on SBWE efficiency, and thus, it can be optimized. The optimal temperature ranges from 130 to 240 °C for extracting the natural products mentioned above. This review can help readers learn more about the SBWE technology, especially for readers with an interest in the field of green extraction of natural products. The major advantage of SBWE of natural products is that water is nontoxic, and therefore, it is more suitable for the extraction of herbs, vegetables, and fruits. Another advantage is that no liquid waste disposal is required after SBWE. Compared with organic solvents, subcritical water not only has advantages in ecology, economy, and safety, but also its density, ion product, and dielectric constant can be adjusted by temperature. These tunable properties allow subcritical water to carry out class selective extractions such as extracting polar compounds at lower temperatures and less polar ingredients at higher temperatures. SBWE can mimic the traditional herbal decoction for preparing herbal medication and with higher extraction efficiency. Since SBWE employs high-temperature and high-pressure, great caution is needed for safe operation. Another challenge for application of SBWE is potential organic degradation under high temperature conditions. We highly recommend conducting analyte stability checks when carrying out SBWE. For analytes with poor SBWE efficiency, a small number of organic modifiers such as ethanol, surfactants, or ionic liquids may be added.

show abstract

Section: Compounds Extracted By Subcritical Watermentioning

confidence: 99%

Subcritical Water Extraction of Natural Products

et al. 2021

View full text Add to dashboard Cite

show abstract

“…First, the crude extract was dissolved in 250 mL of distilled water and extracted twice with nhexane (1:1 v/v) for 6 h at 69 • C and with diethyl ether (1:1 v/v) for 6 h at 34 • C to remove hydrophobic compounds. The aqueous fraction was evaporated to a paste-like form and treated with 100 mL of methanol at room temperature for 24 h to eliminate lowmolecular-weight phenolic compounds [25]. The formed precipitates were recovered by centrifugation at 10,000 rpm for 10 min (Dynamica Velocity 14R Refrigerated Centrifuge, Dynamica Scientific Ltd.; Livingston, United Kingdom) and dried overnight at room temperature.…”

Section: Extraction Proceduresmentioning

confidence: 99%

The Antidiabetic Effect of Grape Pomace Polysaccharide-Polyphenol Complexes

et al. 2021

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic metabolic diseases of the 21st century. Nevertheless, its prevalence might be attenuated by taking advantage of bioactive compounds commonly found in fruits and vegetables. This work is focused on the recovery of polyphenols and polysaccharide–polyphenol conjugates from grape pomace for T2DM management and prevention. Bioactives were extracted by solid–liquid extraction and by pressurized hot water extraction (PHWE). Polyphenolic fraction recovered by PHWE showed the highest value for total phenolic content (427 μg GAE.mg−1), mainly anthocyanins and proanthocyanidins, and higher antioxidant activity compared to the fraction recovered by solid–liquid extraction. Polysaccharide–polyphenol conjugates comprehended pectic polysaccharides to which approximately 108 μg GAE of phenolic compounds (per mg fraction) were estimated to be bound. Polyphenols and polysaccharide–polyphenol conjugates exhibited distinct antidiabetic effects, depending on the extraction methodologies employed. Extracts were particularly relevant in the inhibition of a-glucosidase activity, with free polyphenols showing an IC50 of 0.47 μg.mL−1 while conjugates showed an IC50 of 2.7, 4.0 and 5.2 μg.mL−1 (solid–liquid extraction, PHWE at 95 and 120 °C, respectively). Antiglycation effect was more pronounced for free polyphenols recovered by PHWE, while the attenuation of glucose uptake by Caco-2 monolayers was more efficient for conjugates obtained by PHWE. The antidiabetic effect of grape pomace bioactives opens new opportunities for the exploitation of these agri-food wastes in food nutrition, the next step towards reaching a circular economy in grape products.

show abstract

“…The leaves are used in folk medicine of Vietnam and Thailand for treating various diseases such as hypertension, diarrhea, arthritis, hemorrhoids, stomachache, tumors, colitis, bleeding, wounds, constipation, flu, colon cancer, nephritis, and diabetes [ 181 ]. Polyphenolic–polysaccharide (PP) conjugates obtained from Pseuderanthemum palatiferum (Nees) Radlk leaves exhibit anticoagulant activity by prolonging both APTT and PT [ 182 ]. This effect is probably due to carbohydrate, phenolic, and protein constituents of the PP and to the seven different mono-sugars found in all the conjugates, i.e., arabinose, fucose, galactose, glucose, mannose, rhamnose, and xylose [ 182 ].…”

Section: Antiplatelet and Anticoagulant Activity Of Plants And Their Bioactive Compoundsmentioning

confidence: 99%

“…Polyphenolic–polysaccharide (PP) conjugates obtained from Pseuderanthemum palatiferum (Nees) Radlk leaves exhibit anticoagulant activity by prolonging both APTT and PT [ 182 ]. This effect is probably due to carbohydrate, phenolic, and protein constituents of the PP and to the seven different mono-sugars found in all the conjugates, i.e., arabinose, fucose, galactose, glucose, mannose, rhamnose, and xylose [ 182 ].…”

Section: Antiplatelet and Anticoagulant Activity Of Plants And Their Bioactive Compoundsmentioning

confidence: 99%

Bioactive Natural Compounds with Antiplatelet and Anticoagulant Activity and Their Potential Role in the Treatment of Thrombotic Disorders

Lamponi

2021

Life

View full text Add to dashboard Cite

Natural anticoagulant drugs can be obtained from plants, rich in secondary bioactive metabolites which, in addition to being effective antioxidants, also possess anticoagulant and antiplatelet properties and, for this reason, can be excellent candidates for the treatment of thrombotic diseases. This review reports an overview of the hemostatic process and thrombotic disorders together with data on plants, more and less common from around the world, containing bioactive compounds characterized by antiplatelet and anticoagulant activity. The reported literature was obtained from Medline, PubMed, Elsevier, Web of Science, Google Scholar considering only articles in the English language, published in peer-reviewed journals. The number of citations of the articles and the impact factor of the journals were other parameters used to select the scientific papers to be included in the review. The analysis of the literature data selected demonstrates that many plants’ bioactive compounds show antiplatelet and anticoagulant activity that make them potential candidates to be used as new natural compounds able to interfere with both primary and secondary hemostasis. Moreover, they could be used together with anticoagulants currently administered in clinical practice to increase their efficacy and to reduce complications in the treatment of thrombotic disorders.

show abstract

Green extraction of polyphenolic-polysaccharide conjugates from Pseuderanthemum palatiferum (Nees) Radlk.: Chemical profile and anticoagulant activity

Cited by 16 publications

References 45 publications

Subcritical Water Extraction of Natural Products

Subcritical Water Extraction of Natural Products

The Antidiabetic Effect of Grape Pomace Polysaccharide-Polyphenol Complexes

Bioactive Natural Compounds with Antiplatelet and Anticoagulant Activity and Their Potential Role in the Treatment of Thrombotic Disorders

Contact Info

Product

Resources

About