Green formulation, characterization, antifungal and biological safety evaluation of terbinafine HCl niosomes and niosomal gels manufactured by eco-friendly green method

Morteza‐Semnani, Katayoun; Saeedi, Majid; Âkbari, Jafar; Hedayati, Shakiba; Hashemi, Seyyed Mohammad Hassan; Rahimnia, Seyyed Mobin; Babaei, Amirhossein; Ghazanfari, Mona; Haghani, Iman; Hedayati, Mohammad Taghi

doi:10.1080/09205063.2022.2103626

Cited by 10 publications

(4 citation statements)

References 50 publications

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“…Group 2 rats received a standard irritant (formalin 1%) solution as the positive control, while drug-loaded nanogels containing gel were topically applied to Group 3 rats. After 24 h, the rats' used sites were examined for erythema and edema and given a score between 0 and 4 based on the severity of their symptoms [70].…”

Section: Skin Irritation Studiesmentioning

confidence: 99%

Topical Delivery of Terbinafine HCL Using Nanogels: A New Approach to Superficial Fungal Infection Treatment

Hassan,

Khalid,

Hussain

et al. 2023

Gels

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This study investigated pH-responsive Terbinafine HCL (TBH)-loaded nanogels as a new approach to treating superficial fungal infections. Acrylic acid (AA) is a synthetic monomer that was crosslinked with a natural polymer (gelatin) using a free radical polymerization technique to fabricate gelatin-g-poly-(acrylic acid) nanogels. Ammonium persulphate (APS) and N, N′-methylene bisacrylamide (MBA) were used as the initiator and crosslinker, respectively. Developed gelatin-g-poly-(acrylic acid) nanogels were evaluated for the swelling study (pH 1.2, 5, 7.4), DEE, particle size, FTIR, thermal stability (TGA, DSC), XRD, SEM, DEE, and in vitro drug release study to obtain optimized nanogels. Optimized nanogels were incorporated into 1% HPMC gel and then evaluated in comparison with Lamisil cream 1% for TBH stratum corneum retention, skin irritation, and in vitro and in vivo antifungal activity studies. Optimized nanogels (AAG 7) demonstrated a 255 nm particle size, 82.37% DEE, pH-dependent swelling, 92.15% of drug release (pH) 7.4 within 12 h, and a larger zone of inhibition compared to Lamisil cream. HPMC-loaded nanogels significantly improved the TBH skin retention percentage, as revealed by an ex vivo skin retention study, indicating the usefulness of nanogels for topical use. In vivo studies conducted on animal models infected with a fungal infection have further confirmed the effectiveness of nanogels compared with the Lamisil cream. Hence, Gelatin-g-poly-(acrylic acid) nanogels carrying poorly soluble TBH can be a promising approach for treating superficial fungal infections.

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Section: Skin Irritation Studiesmentioning

confidence: 99%

Topical Delivery of Terbinafine HCL Using Nanogels: A New Approach to Superficial Fungal Infection Treatment

Hassan,

Khalid,

Hussain

et al. 2023

Gels

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“…36 Although effective at these high concentrations, resistance against Terb used through both oral and topical routes has been observed when such high doses are used. 37 To address these issues, complex nanostructured lipid carriers (NLCs), 38 solid lipid NPs (SLNs), 39 large-polymeric nanosystems, 40 surfactant-derived niosomes, 24 and polymeric hydrogel-NP composites 41 have previously been investigated for Terb delivery. However, unlike the complex and multi-component nature of multiple lipids, surfactants, polymers, etc., 42 here we discuss the use and efficacy of a simple peptide-based nanoparticulate system for redox stimulus (GSH)-responsive Terb delivery, which was formulated primarily in an aqueous-based environment.…”

Section: Drug-loading and -Release Studies Of Terb From Terb-cfo-npsmentioning

confidence: 99%

“…Terb is an allylamine derivative that acts against fungal infections in a wide range of strains by obstructing the formation of ergosterol, which is the major component of the fungal cell membrane. Although other polymeric NPs/hydrogels/nanogels have been utilized for Terb delivery, [22][23][24] peptide-based selfassembled NPs have never been attempted. The CFO-NPs described here were formulated in an aqueous environment, which accounted for their higher biocompatibility as well as providing their safer therapeutic utility, we believe that this could be a simple and effective strategy for the delivery of these and other antifungal drugs into yeasts and other fungal species.…”

Section: Introductionmentioning

confidence: 99%

Cysteine–phenylalanine-derived self-assembled nanoparticles as glutathione-responsive drug-delivery systems in yeast

et al. 2022

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“…Most of these techniques are based on chromatographic methods, [8] including HPLC with UV detection, [9,10] HPLC-MS detection [11,12] and capillary zone electrophoresis. [13] Terbinafine has been determined spectrophotometrically, [14,15] voltammetrically [16] and potentiometrically. [17][18][19] However, these methods require more time-consuming manipulations, expensive chemicals and mod-ern equipment.…”

Section: Introductionmentioning

confidence: 99%

A Novel Potentiometric Coated Wire Sensor Based on Functionalized Polymeric CaO/ZnO Nanocomposite Synthesized by Lavandula Spica Mediated Extract for Terbinafine Determination

Alterary,

Mostafa,

El‐Tohamy

et al. 2024

ChemistrySelect

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The unique properties of calcium oxide (CaO) and zinc oxide (ZnO) at the nanoscale have attracted the interest of scientists as promising electrically conductive substances for sensing purposes. The content of terbinafine hydrochloride (TRF) in pharmaceutical tablets was determined using a novel coated, wire‐functionalized CaO/ZnO nanocomposite membrane sensor biogenically produced from Lavandula spica extract. Sodium tetraphenylborate was used to prepare the active material (TRF‐TBP). The newly modified sensor gave excellent potentiometric sensitivity with the least squares regression equation EmV=(−58.88X±0.3)+log [TRF]+549.78 and covered a wide linear range (5.0×10−9–1.0×10−2 mol/L) of TRF samples. In contrast, the standard TRF‐TBP sensor wasn't as sensitive when (2.5×10−6–1.0×10−2 mol/L). TRF solutions with regression equation of (−55.728X±0.7)+log [TRF]+396.64. The appropriate pH range was 3–6. The principles of analytical methodology were applied to investigate the validity and suitability of the proposed technique. The proposed sensors were found to be suitable and efficient for the detection of TRF on tablets.

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Green formulation, characterization, antifungal and biological safety evaluation of terbinafine HCl niosomes and niosomal gels manufactured by eco-friendly green method

Cited by 10 publications

References 50 publications

Topical Delivery of Terbinafine HCL Using Nanogels: A New Approach to Superficial Fungal Infection Treatment

Topical Delivery of Terbinafine HCL Using Nanogels: A New Approach to Superficial Fungal Infection Treatment

Cysteine–phenylalanine-derived self-assembled nanoparticles as glutathione-responsive drug-delivery systems in yeast

A Novel Potentiometric Coated Wire Sensor Based on Functionalized Polymeric CaO/ZnO Nanocomposite Synthesized by Lavandula Spica Mediated Extract for Terbinafine Determination

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