Green formulation of curcumin loaded lipid-based nanoparticles as a novel carrier for inhibition of post-angioplasty restenosis

Akhlaghi, Sarah; Rabbani, Shahram; Alavi, Sonia; Alinaghi, Azadeh; Radfar, Fatemeh; Dadashzadeh, Simin; Haeri, Azadeh

doi:10.1016/j.msec.2019.110037

Cited by 20 publications

(4 citation statements)

References 51 publications

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“…The nanosize of these components and their engineered surface helps them pass through the vessels to reach a specific organ [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. Thus, nanocarriers have been extensively used for the encapsulation of different phytochemicals, including NRG or naringin which is its glycosidic form [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ].…”

Section: Introductionmentioning

confidence: 99%

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

et al. 2021

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Naringenin (NRG) is a polyphenolic phytochemical belonging to the class of flavanones and is widely distributed in citrus fruits and some other fruits such as bergamot, tomatoes, cocoa, and cherries. NRG presents several interesting pharmacological properties, such as anti-cancer, anti-oxidant, and anti-inflammatory activities. However, the therapeutic potential of NRG is hampered due to its hydrophobic nature, which leads to poor bioavailability. Here, we review a wide range of nanocarriers that have been used as delivery systems for NRG, including polymeric nanoparticles, micelles, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, and nanoemulsions. These nanomedicine formulations of NRG have been applied as a potential treatment for several diseases, using a wide range of in vitro, ex vivo, and in vivo models and different routes of administration. From this review, it can be concluded that NRG is a potential therapeutic option for the treatment of various diseases such as cancer, neurological disorders, liver diseases, ocular disorders, inflammatory diseases, skin diseases, and diabetes when formulated in the appropriate nanocarriers.

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Section: Introductionmentioning

confidence: 99%

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

et al. 2021

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“…Differential Scanning Calorimetry (DSC) thermograms of Plain-NP, CUR-NP, free CUR, and PLU are presented in Figure 3 . Free CUR display melting temperatures at 184 °C [ 35 ]. The CUR-NP did present a sighlyty amorphous peak at 60 °C corresponding to the melting temperature of PLU.…”

Section: Resultsmentioning

confidence: 99%

Curcumin Hybrid Lipid Polymeric Nanoparticles: Antioxidant Activity, Immune Cellular Response, and Cytotoxicity Evaluation

et al. 2022

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Poor solubility and short biological half-life present a challenge that needs to be overcome in order to improve the recognized bioactivities of curcumin (CUR), the main phenolic compounds derived from the roots of Curcuma longa. However, drug delivery systems have proven to be an excellent strategy to improve and obtain greater bioavailability. Our previous studies on curcuminoid hybrid nanoparticles have shown promising results by significantly increasing the solubility of desmethoxycurcumin (DMC) and bisdemethoxycurcumin (BDM). In this contribution, we performed a detailed characterization of a CUR as well as in vitro and in vivo studies. The developed method produced CUR loaded nanoparticles with an average size of 49.46 ± 0.80. Moreover, the FT-IR analysis confirmed the encapsulation, and TEM images showed their spherical shape. The NP achieved an encapsulation efficiency greater than 99%. Further, the release studies found that the NPs obtained a significantly higher release than the pure compounds in water. In vivo delayed-type hypersensitivity (DTH) studies showed promising results by enhancing the immune activity response of CUR in NP compared to bulk CUR. Furthermore, we report a significant increase in antioxidant activity for CUR-NP in aqueous solution compared to free CUR. Finally, an important in vitro cytotoxic effect on gastric AGS and colon SW620 adenocarcinoma cell lines was found for CUR-NP while empty carrier nanoparticles are observed to exhibit low cytotoxicity, indicating the potential of these CUR-PLU NPs for further studies to assess their phytotherapeutic applications.

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“…To date, several anti-proliferative drugs, such as rapamycin, paclitaxel, doxorubicin, honokiol, heparin, low molecular weight heparin (LMWH), curcumin, and 1α,25(OH) 2 D 3 have been developed and applied for the treatment of vascular restenosis. 450 , 451 However, their clinical application is seriously limited by poor solubility and side effects. To circumvent these problems, researchers have applied nanoparticles to deliver anti-proliferative drugs and achieved excellent results.…”

Section: Nanoparticle-based Therapeutic Methods For Vascular Aging-re...mentioning

confidence: 99%

Nanoparticles in the diagnosis and treatment of vascular aging and related diseases

Liu

2022

Sig Transduct Target Ther

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Aging-induced alternations of vasculature structures, phenotypes, and functions are key in the occurrence and development of vascular aging-related diseases. Multiple molecular and cellular events, such as oxidative stress, mitochondrial dysfunction, vascular inflammation, cellular senescence, and epigenetic alterations are highly associated with vascular aging physiopathology. Advances in nanoparticles and nanotechnology, which can realize sensitive diagnostic modalities, efficient medical treatment, and better prognosis as well as less adverse effects on non-target tissues, provide an amazing window in the field of vascular aging and related diseases. Throughout this review, we presented current knowledge on classification of nanoparticles and the relationship between vascular aging and related diseases. Importantly, we comprehensively summarized the potential of nanoparticles-based diagnostic and therapeutic techniques in vascular aging and related diseases, including cardiovascular diseases, cerebrovascular diseases, as well as chronic kidney diseases, and discussed the advantages and limitations of their clinical applications.

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Green formulation of curcumin loaded lipid-based nanoparticles as a novel carrier for inhibition of post-angioplasty restenosis

Cited by 20 publications

References 51 publications

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

Curcumin Hybrid Lipid Polymeric Nanoparticles: Antioxidant Activity, Immune Cellular Response, and Cytotoxicity Evaluation

Nanoparticles in the diagnosis and treatment of vascular aging and related diseases

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