Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction

Chafran, Liana S.; Carfagno, Amy; Altalhi, Amaal; Bishop, Barney

doi:10.3390/polym14214755

Cited by 15 publications

(8 citation statements)

References 212 publications

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“…Additionally, amide bonds (CONH) can be crosslinked with frameworks such as chitosan or the peptide itself through hydrogen bonding 37,38 . In general, the characteristics of hydrogels are primarily regulated by various factors, including high‐quality materials, component ratios, crosslinking agents, and environmental conditions (pH, temperature, and light) 39–41 . However, the effect of AMPs on the property of hydrogels still required further investigation.…”

Section: Discussionmentioning

confidence: 99%

The effect of antimicrobial peptide HX‐12C on the properties of chitosan/polyacrylic acid hydrogel

Tang,

Du,

Zhao

et al. 2024

J of Applied Polymer Sci

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Antimicrobial peptide (AMP) hydrogel is a novel biomaterial widely used in wound healing. However, there have been limited studies investigating the effect of AMP on hydrogel properties so far. Therefore, this study aimed to examine the influence of the AMP HX‐12C on the chitosan/polyacrylic acid (CS/PAA) double‐network (DN) hydrogel. The results showed that the mechanical properties of CS/PAA/HX‐12C hydrogel are significantly improved compared with those of CS/PAA hydrogel. The maximum tensile stress increased from 41.0 to 258.5 KPa, and the compression stress required for 80% hydrogel deformation increased from 3.7 to 6.7 MPa. Furthermore, the thermal stability of CS/PAA/HX‐12C showed a noticeable enhancement when compared with CS/PAA hydrogel. In addition, the CS/PAA/HX‐12C hydrogel exhibited improved porosity and swelling performance. The addition of HX‐12C significantly enhanced the antibacterial activity of the hydrogel against Escherichia coli and methicillin‐resistant Staphylococcus aureus. Cytotoxicity test showed that the viability of L929 cell remained above 90% after treatment with CS/PAA/HX‐12C hydrogel extract, indicating the good biocompatibility. In conclusion, AMP assuredly enhances the mechanical property, swelling performance and antimicrobial activity of hydrogel. The CS/PAA/HX‐12C hydrogel shows potential for use as anti‐infective medical material.

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Section: Discussionmentioning

confidence: 99%

The effect of antimicrobial peptide HX‐12C on the properties of chitosan/polyacrylic acid hydrogel

Tang,

Du,

Zhao

et al. 2024

J of Applied Polymer Sci

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“…After 5 h, the dispersion was homogenized using a Heidolph MR Hei-Standard (Heidolph Instruments GmbH&Co, Germany) magnetic stirrer and then degassed. The glycerol (10 g per 100 g final gel) was used to give stretchability [ 56 ] and, as a biodegradable material, is compatible with the principles of green chemistry [ 57 ]. For the stability [ 58 ], the gel matrix was stirred for 1 week.…”

Section: Methodsmentioning

confidence: 99%

Nanofluorapatite Hydrogels in the Treatment of Dentin Hypersensitivity: A Study of Physiochemical Properties and Fluoride Release

Wiglusz

Gutbier

Wiglusz

2023

Gels

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The aim of this work was to prepare a new hydrogel based on nanohydroxyapatite (nFAP, 10% w/w) and fluorides (4% w/w), both of which are used as sources of fluoride ions in the treatment of dentin hypersensitivity, and to characterize its physicochemical properties. The release of fluoride ions from 3 gels (G-F, G-F-nFAP, and G-nFAP gel) was controlled in Fusayama–Meyer artificial saliva at pH 4.5, 6.6, and 8.0. The properties of the formulations were determined by an analysis of viscosity, a shear rate test, a swelling study, and gel aging. Various methods, i.e., FT-IR spectroscopy, UV-VIS spectroscopy, and thermogravimetric, electrochemical, and rheological analysis, were used for the experiment. The profiles of fluoride release indicate that the amount of fluoride ions released increases with a decrease in the pH value. The low pH value facilitated water absorption by the hydrogel, which was also confirmed by the swelling test, and it promoted the exchange of ions with the surrounding environment. Under conditions similar to physiological conditions (at pH 6.6), the amounts of fluorides released into artificial saliva were approximately 250 µg/cm2 and 300 µg/cm2 for the G-F-nFAP hydrogel and G-F hydrogel, respectively. The aging study and properties of the gels showed a loosening of the gel network structure. The Casson rheological model was used to assess the rheological properties of the non-Newtonian fluids. Hydrogels consisting of nanohydroxyapatite and sodium fluoride are promising biomaterials in the prevention and management of the dentin hypersensitivity.

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“…Renewable green resources from nature have the potential to serve as alternative input for both large-scale chemical production of consumer products [ 1 , 2 ], as well as for biomedical applications [ 3 , 4 , 5 ]. The underlying “biobased economy” has secured priority on the agendas of national and international governmental institutions [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (CyreneTM)

et al. 2023

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Biomass-derived molecules can provide a basis for sustainable drug discovery. However, their full exploration is hampered by the dominance of millions of old-fashioned screening compounds in classical high-throughput screening (HTS) libraries frequently utilized. We propose a fragment-based drug discovery (FBDD) approach as an efficient method to navigate biomass-derived drug space. Here, we perform a proof-of-concept study with dihydrolevoglucosenone (CyreneTM), a pyrolysis product of cellulose. Diverse synthetic routes afforded a 100-membered fragment library with a diversity in functional groups appended. The library overall performs well in terms of novelty, physicochemical properties, aqueous solubility, stability, and three-dimensionality. Our study suggests that Cyrene-based fragments are a valuable green addition to the drug discovery toolbox. Our findings can help in paving the way for new hit drug candidates that are based on renewable resources.

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Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction

Cited by 15 publications

References 212 publications

The effect of antimicrobial peptide HX‐12C on the properties of chitosan/polyacrylic acid hydrogel

The effect of antimicrobial peptide HX‐12C on the properties of chitosan/polyacrylic acid hydrogel

Nanofluorapatite Hydrogels in the Treatment of Dentin Hypersensitivity: A Study of Physiochemical Properties and Fluoride Release

Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (CyreneTM)

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