Trench defects in multi‐quantum wells (MQWs) have been considered as flawed structures that severely degraded the internal quantum efficiency (IQE) of light‐emitting diodes (LEDs) in the past. In this research, trench defects are innovatively utilized to enhance the efficiency of red InGaN LEDs. Specifically, dual‐color MQWs structures are applied to modulate trench defects. The upper red MQWs, grown on top of green MQWs with a high density of trench defects, exhibit a significant wavelength redshift of 68 nm and ≈ 6‐fold luminescence enhancement compared to those without intentionally introduced trench defects. Red InGaN LEDs with an IQE of 16.4% are achieved with this epitaxy growth strategy. Such wavelength redshift is attributed to the more indium incorporation due to the strain relaxation effect of trench defects. Moreover, the luminescence enhancement originates from the strong emission of the red MQWs inside trench defects, mainly attributed to strain relaxation and defect shielding by the wide and deep trenches. Achieving red emission by modulating trench defects is simple and reproducible without requiring additional substrate designs, which provides a novel way toward high‐efficiency red InGaN LEDs.