Green-lipped mussel (Perna canaliculus) extract efficacy in knee osteoarthritis and improvement in gastrointestinal dysfunction: a pilot study

Abstract

Green-lipped mussel significantly improved knee joint pain, stiffness and mobility. We report for the first time that the administration of GLM extract also significantly improved GI symptoms by 49% in OA patients. Given that GI dysfunction is linked to analgesic medication use, we further conclude that the therapeutic efficacy of the GLM extract used was possibly correlated to its effects on GI function by improving GSRS scores from baseline. Results from this trial highlight the requisite for further clinical investigations of gastrointestinal tract function in OA patients.

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

“…Previously reviewed published human studies of probiotics and of prebiotics (a nutritional supplement favoring the growth and increasing the lifespan of probiotic bacteria) demonstrate their effects on several clinical scenarios (Vitetta and Sali 2008;Vitetta et al 2012Vitetta et al , 2014a. Their beneficial effects can occur when the internal human environment is influenced by the commensal/probiotic environment throughout the digestive tract.…”

“…Lipid and whole extracts reinforce the anti-inflammatory therapeutic activity of acetylsalicylic acid and indomethacin while concomitantly exhibiting gastroprotective activity (Rainsford and Whitehouse 1980). Supportive data indicates that supplementation with whole P. canaliculus extract may support GIT function and even show gastroprotective activity when administered with anti-inflammatory and analgesic medications in patients with OA (Coulson et al 2012(Coulson et al , 2013. Further, preliminary evidence has demonstrated that the SFE lipid-rich fraction significantly reduced colonic damage in an inflammatory bowel disease (IBD) animal model (Tenikoff et al2005) and partially improved selected indicators of intestinal inflammation and intestinal morphology in an animal model of chemotherapy-induced mucositis.…”

“…It is extensively reported that probiotics can temper a range of GIT physiological functions, including control over immune responses, epithelial barrier function, and cellular proliferation (Vitetta et al 2012). A recent study has demonstrated that some genera of human GIT bacteria can induce a rapid increase of ROS, eliciting a physiological response through the activation of epithelial NADPH oxidase-1 (Nox1) (Bermudez-Brito et al 2012;Neish 2013).…”

“…It has supported the development of commercial therapeutic products to treat arthralgia in humans and animals. It has also been assessed as an adjunct therapy for rheumatoid arthritis (RA), asthma and gastrointestinal tract (GIT) complaints (Gibson et al 1980;Gibson and Gibson 1998;Coulson et al 2012;Mickleborough et al 2013). P. canaliculus is manufactured in New Zealand as unadulterated freeze-dried whole (i.e.…”

Synofit Premium in Refractory Low Back Pain: A Retrospective Observational Study

“…Results of as a systematic review suggest that a Perna canaliculus supplement may be superior to placebo in the treatment of mild to moderate osteoarthritis [1], probably linked to an analgesic effect. In addition, Perna canaliculus inhibits the 5-lipoxygenase and cyclo-oxygenase 1 and 2 pathways [2], which lead to the formation of the leukotrienes and prostaglandins that contribute to the inflammatory process [3] [4]. Ribes nigrum leaf, which is particularly rich in polyphenols, is among the most active extracts for inhibiting cytosolic phospholipase A2 alpha [5], and curcumin has been used for a long time in complementary medicine for a series of conditions, including osteoarthritis, because of its anti-inflammatory and anti-oxidant effects [6] [7] [8].…”