Developing a balance between manufacturing and ecological preservation is considered a major issue in every society and so attention must be paid to this relationship to protect plant, animal and human lives. Pressure for manufacturing firms to become green has risen greatly. Green manufacturing has been encouraged, practiced and researched for years but mostly in developed nations, but low in developing countries. This is a follow up study on a previous one conducted by the authors on the direct effects of green drivers on green practices, and this current one aims at the moderating role of sustainability orientation on the effects of driving factors on green practices in Ghana. Analysis was done using structural equation modeling (SEM). Evidently, sustainability orientation (SUO) moderated significantly between driving factors and green design practices, green purchasing practices and green promotion/selling. Green design practices adoption was facilitated most by SUO. Green management practices and green logistics practices were not moderated by SUO. Outcomes of this work could serve as a guide towards decision making by industry actors and government of Ghana on policy formulation and better processes for integrating green practices, not just in the agro processing industry but all others with activities of possible damage to the environment.