Green Method for Acetaminophen and Ibuprofen Simultaneous Assay in the Combination Tablet Using Ftir

Abstract

Objective: The purpose of this study was to develop a green method for assay the tablet consists of a combination of acetaminophen (ACT)-ibuprofen (IBU). FTIR (Fourier Transform Infrared Spectroscopy), which is commonly used for qualitative analysis, was developed to measure the tablet contents, directly and quantitatively.Methods: Standard for ACT and IBU was respectively mixed with KBr crystal in varied and measured using FTIR. The transmission spectrum yielded later was converted into its absorbance-derivatized forms which then a calibration curve was composed using the data. Once validated, the analytical method was conducted on samples of the branded ACT-IBU combination tablet.Results: ACT had a specific wavenumber of a group N-H stretch, meanwhile IBU was represented by the C = O spectrum. These peaks then used for quantitative calculation basis levels respectively. The limits of detection and quantitation of ACT consecutively were % w/w and  w/w and IBU were % w/w and  w/w. Next; the method was carried out successfully to evaluate the content of sample tablet from the market.Conclusion: The analytical method of ACT-IBU was proven applicable and suitable for the quantitative purpose. The method shows meet with the expectation such as simple and easy to perform and reduce the use of solvents.

Utilization of charge transfer complexation reaction for the spectrophotometric determination of acyclovir as antiviral drug in pharmaceutical formulations

“…Figure (1). The chemical structure of acyclovir (ACV) ACV has been determined in pure form, dosage forms, and biological fluids using a variety of analytical methods, including chromatography [3][4][5][6], electrochemistry [7][8][9][10], spectrofluorimetry [11][12][13], flow injection [14], FT-IR [15], and spectrophotometry [13,[16][17][18][19][20][21][22][23][24][25][26][27][28][29]. The depicted analytical techniques that have been reported for the determination of ACV appear to depend on the use of a practical instrument for the majority of these techniques.…”

Ultrasound-assisted dispersive liquid-liquid microextraction approach for preconcentration of acyclovir as antiviral drug in dosage forms prior to spectrophotometric determination

“…ACV has been determined in pure form, dosage forms, and biological fluids using a variety of analytical methods, including chromatography [3][4][5][6], electrochemistry [7][8][9][10], spectrofluorimetry [11][12][13], flow injection [14], FT-IR [15], and spectrophotometry [13,[16][17][18][19][20][21][22][23][24][25][26][27][28][29]. The depicted analytical methods that have been described for the estimation of ACV appear to depend on the use of a practical instrument for the majority of these techniques.…”