Green, one-pot synthesis of α-aminophosphonates catalyzed by ZnI2 at room temperature

Abstract

An effi cient, green and simple solvent-free method is described for the synthesis of α -aminophosphonates based on one-pot three-component condensation of trimethylphosphite, aldehydes and amines in the presence of zinc iodide. This method offers some advantages such as shorter reaction times, simple work-up and excellent yield at room temperature.

Solvent‐Free Synthesis and In Vitro Antitumor Activity of a New Class of (Z)‐3‐Arylidene‐1H‐pyrano[3,4‐b]quinolin‐4(3H)‐ones

“…For this purpose, we first investigated the solventfree reaction of 7 a with 1.1 equiv. of benzaldehyde based on a published method using p-toluenesulfonic acid (p-TSA) as the catalyst, [19] expecting to obtain the corresponding quinolinebased α-arylidene cycloketone 6 a. Unfortunately, contrary to our expectation, this was not the case in our hands and the reaction did not proceed satisfactorily, giving a poor yield of highly impure product (Entry 1, Table 1).…”

Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Their Corresponding 2(1H)Thiones Using Trichloroacetic Acid as a Catalyst under Solvent-Free Conditions

“…With the awareness of environmental issues and importance of this reaction and keeping our interest in the development of synthetic routes to heterocyclic compounds [23–27], herein, we report a heterogeneous, solid trichloroacetic acid, as an alternative, cheap, and efficient catalyst for the Biginelli reaction (Scheme 1). …”