Green one-step reduction approach to prepare rGO@AgNPs coupled with molecularly imprinted polymer for selective electrochemical detection of lactic acid as a cancer biomarker

Fabrication of a Lactate-Specific Molecularly Imprinted Polymer toward Disease Detection

“…Although some of the devices report a wider linear range and lower sensitivities, their concentration levels are not in the specific range we are targeting that can indicate infection. Moussa and Zhou et al focused their efforts on the continuous monitoring of lactate levels during periods of exercise and the detection of lactic acid as a cancer biomarker, respectively. , Similarly, Xuan et al fabricated a wearable lactate sensor for sweat analysis, demonstrating a linear range of response significantly below the anticipated lactate levels in sweat together as a promising technology for the sports domain …”

“…Moussa and Zhou et al focused their efforts on the continuous monitoring of lactate levels during periods of exercise and the detection of lactic acid as a cancer biomarker, respectively. 66,67 Similarly, Xuan et al fabricated a wearable lactate sensor for sweat analysis, demonstrating a linear range of response significantly below the anticipated lactate levels in sweat together as a promising technology for the sports domain. 9 Where the sample media constitutes sweat, our MIP powders demonstrate greater sensitivity, with a wider linear range than the organic electrochemical transistor (OECT) sensor.…”

Synthesis and Characterization of CuO@PANI composite: A new prospective material for electrochemical sensing

“…Due to their excellent physical and catalytic characteristics, nanoparticles (NPs) such as metal oxide have been used in electrochemistry to increase their electro-catalytic efficiency [8][9][10]. In addition, the high surface area [11], antibacterial activity [12] and drug delivery [13] make such materials effective substrate for fabrication of novel composites material for various fields [14][15][16]. In addition, Nanomaterials and their nanocomposites with unique atomic thickness are promising materials for various applications including tissue engineering [16], energy storage [17,18], water related applications [18] and catalytic industries [20][21][22] due to their outstanding properties such as high mechanical strength, large surface area, good chemical and thermal stability, ease of functionalization, and hydrophilic surface.For instance, Benmoussa et al, proposed a novel electrochemical biosensor to detect cancer biomarker (lactic acid) based on organic-inorganic composite coupled with a molecularly imprinted polymer to create a highly sensitive and selective electrochemical biosensor where a limit of detection around 0.726 μM has been determined [14].…”

“…In addition, the high surface area [11], antibacterial activity [12] and drug delivery [13] make such materials effective substrate for fabrication of novel composites material for various fields [14][15][16]. In addition, Nanomaterials and their nanocomposites with unique atomic thickness are promising materials for various applications including tissue engineering [16], energy storage [17,18], water related applications [18] and catalytic industries [20][21][22] due to their outstanding properties such as high mechanical strength, large surface area, good chemical and thermal stability, ease of functionalization, and hydrophilic surface.For instance, Benmoussa et al, proposed a novel electrochemical biosensor to detect cancer biomarker (lactic acid) based on organic-inorganic composite coupled with a molecularly imprinted polymer to create a highly sensitive and selective electrochemical biosensor where a limit of detection around 0.726 μM has been determined [14]. Hence, The NPs-modified electrode enhanced signal responsiveness, sensitivity, and repeatability [23][24][25][26][27], and it has several bioscience applications.Furthermore, the characteristics of composite materials are determined by the morphology of the phases, which must be regulated across many length scales [25][26][27][28].…”

“…For instance, Benmoussa et al, proposed a novel electrochemical biosensor to detect cancer biomarker (lactic acid) based on organic-inorganic composite coupled with a molecularly imprinted polymer to create a highly sensitive and selective electrochemical biosensor where a limit of detection around 0.726 μM has been determined [14]. Hence, The NPs-modified electrode enhanced signal responsiveness, sensitivity, and repeatability [23][24][25][26][27], and it has several bioscience applications.…”