Green, oolong and black tea extracts modulate lipid metabolism in hyperlipidemia rats fed high-sucrose diet

Yang, Ming-Hua; Wang, Cheng-Hsin; Chen, Hsiao‐Ling

doi:10.1016/s0955-2863(00)00140-6

Cited by 149 publications

(120 citation statements)

References 12 publications

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“…5). catechins on visceral fat accumulation has been extensively studied in experimental models using a high-caloric diet (4,9,16,20,25). The present study using normal rats fed a normal diet showed a meaningful reduction in intra-abdominal fat storage with ad libitum drinking water containing tea catechins.…”

Section: Serum Level Of Bile Acidsmentioning

confidence: 50%

Effect of tea catechins on body fat accumulation in rats fed a normal diet

et al. 2008

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Although it is known that tea catechins exert potent effects in obese subjects, there is scant information concerning these effects on body weight gain and body fat accumulation in the non-obese. We studied normal rats fed a normal diet and water containing either 0.1% or 0.5% tea catechins to examine the effects on body fat content and serum cholesterol levels, as well as evaluating whether the effect is related to bile acids, which in recent years have emerged as an inducer of energy expenditure. The administration of 0.5% catechins decreased the accumulation of body fat and the serum levels of cholesterol and bile acids. These results indicate that tea catechins modulate lipid metabolism not only in obese subjects, but also in the non-obese.Green tea, a popular beverage in Asian countries, contains a series of polyphenols known as catechins, in particular epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC) and epigallocatechin gallate (EGCG) (3, 14, 15, 21). There is considerable interest in the anti-obesity potential of green tea (24), as several reports have shown that administration of polyphenols resulted in a significant reduction in body weight gain and body fat accumulation induced by a high-fat diet in animal models (9,16,20). But despite the great interest, there is scant information concerning the effects of tea catechins on body weight gain and body fat accumulation in non-obese subjects.Bile acids are synthesized from cholesterol in the liver, and secreted after meals to promote absorption of fat from the intestine. Although it has been shown that bile acids also mitigate diet-induced obesity (11), that finding has attracted limited attention. Recently, Watanabe et al. (23) confirmed and expanded this observation, showing that feeding mice with cholic acid moderated the effects of a high-fat diet. The novel metabolic effect of bile acids is critically dependent on inducing energy expenditure by promoting intracellular thyroid hormone activation (23). It is unclear whether the tea catechins-induced reduction in body weight gain is related to increased metabolism induced by bile acids.Therefore, we performed a study in normal rats fed a normal diet to examine the effects on body fat content and the levels of serum cholesterol and bile acids. MATERIALS AND METHODSTea catechins. We used a crude catechin extract (Teafuran 90S; Itoen Ltd, Tokyo, Japan) containing 55.5% (w/w) EGCG and 19% others (EC, ECG, EGC). According to the manufacturer, the total polyphenol content was 94%, and caffeine content was 0.6%.Animals. Male Wistar rats (200-250 g) were purchased at 7 weeks of age (Clea Japan Inc., Tokyo,

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Section: Serum Level Of Bile Acidsmentioning

confidence: 50%

Effect of tea catechins on body fat accumulation in rats fed a normal diet

et al. 2008

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“…Although many studies have been explaining how tea influences dietary lipid metabolism, the detailed mechanism is not yet fully understood. It has been demonstrated that tea catechins, such as (À)-epicatechin, (À)-epigallocatechin, (À)-epicatechingallate and (À)-epigallocatechingallate(EGCG) activate hepatic lipid metabolism and result in the suppression of diet-induced obesity in rats (Chan et al, 1999;Yang et al, 2001;Murase et al, 2002;Raederstorff et al, 2003). Ikeda et al (1992) have found that EGCG, the major component of catechins in green tea, inhibits pancreatic lipase in vitro and cholesterol absorption, and lymphatic TG absorption in rats.…”

Section: Discussionmentioning

confidence: 99%

Polyphenol-enriched oolong tea increases fecal lipid excretion

Kusumoto

Abe

et al. 2006

Eur J Clin Nutr

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Objective: To assess possibility of polyphenol-enriched oolong tea to reduce dietary lipid absorption in humans. Design: Twelve healthy adult subjects, three males and nine females, aged (mean7s.d.) 22.071.8 years, respectively, were randomly divided into two groups. The participants were followed a double-blind placebo-controlled crossover design, including 7-day washout periods and 10-day treatment periods. During the treatment periods, subjects were given about 38 g of lipids from potato chips (19 g each within 30 min after lunch and dinner) and total 750 ml beverages (placebo-or polyphenolenriched oolong tea) at three meals. Blood samples were collected for biochemical examination at days 8, 18, 25 and 35 of the study period. On the last 3 days of each treatment period, feces were collected to measure the excretion of lipids. Results: Lipid excretion into feces was significantly higher in the polyphenol-enriched oolong tea period (19.3712.9 g/3day) than in the placebo period (9.477.3 g/3day) (Po0.01). Cholesterol excretion tended to increase in polyphenol-enriched oolong tea period (1.871.2 g/3day) compared with that of placebo (1.270.6 g/3day) (P ¼ 0.056). Conclusions:The results of this study indicated that polyphenol-enriched oolong tea could increase lipid excretion into feces when subjects took high-lipid diet.

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“…Epidemiological studies and experimental data show that drinking green tea or administration of its components, green tea catechins (GTCs), is associated with a lower risk of obesity [3][4][5][6][7][8][9][10]. Moreover, GTCs are involved in modulating fat metabolism [3,5,6,8,[11][12][13], but the mechanisms are not clear.…”

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confidence: 99%

Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors

Yan

Zhao

Bao

2013

Sci. China Life Sci.

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Epidemiological evidence and experimental studies suggest that drinking green tea is associated with a lower risk of obesity and related diseases. However, the mechanisms of these effects are not clear. In the present study, we investigated the antiobesity mechanisms of green tea catechins (GTCs) through modulation of peroxisome proliferator activated-receptor (PPAR) pathways in high-fat diet-induced obesity in rats. GTC supplementation significantly attenuated the increased body and liver weights and the elevated serum and liver triglyceride levels. Meanwhile, GTCs increased the PPARγ levels in subcutaneous white adipose tissue (SWAT) and decreased the PPAR levels in visceral white adipose tissue (VWAT). In addition, GTC treatment up-regulated the levels of PPARδ in SWAT, VWAT, and brown adipose tissue and increased the expression of genes involved in fatty acid oxidation in brown adipose tissue. Our results suggest that GTCs exert their anti-obesity mechanism in part by modulating PPAR signaling pathways. obesity, green tea catechins, peroxisome proliferator activated-receptors (PPARs), hyperlipidemia, metabolic syndrome

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Green, oolong and black tea extracts modulate lipid metabolism in hyperlipidemia rats fed high-sucrose diet

Cited by 149 publications

References 12 publications

Effect of tea catechins on body fat accumulation in rats fed a normal diet

Effect of tea catechins on body fat accumulation in rats fed a normal diet

Polyphenol-enriched oolong tea increases fecal lipid excretion

Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors

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