Abstract-Cell densification is being perceived as the panacea for the imminent capacity crunch. However, high aggregated energy consumption and increased inter-cell interference (ICI) caused by densification, remain the two long-standing problems. We propose a novel network orchestration solution for simultaneously minimizing energy consumption and ICI in ultra-dense 5G networks. The proposed solution builds on a big data analysis of over 10 million CDRs from a real network that shows there exists strong spatio-temporal predictability in real network traffic patterns. Leveraging this we develop a novel scheme to pro-actively schedule radio resources and small cell sleep cycles yielding substantial energy savings and reduced ICI, without compromising the users QoS. This scheme is derived by formulating a joint Energy Consumption and ICI minimization problem and solving it through a combination of linear binary integer programming, and progressive analysis based heuristic algorithm. Evaluations using: 1) a HetNet deployment designed for Milan city where big data analytics are used on real CDRs data from the Telecom Italia network to model traffic patterns, 2) NS-3 based Monte-Carlo simulations with synthetic Poisson traffic show that, compared to full frequency reuse and always on approach, in best case, proposed scheme can reduce energy consumption in HetNets to 1/8th while providing same or better QoS.