One e cient method for the synthesis of 3,4-disubstituted isoxazole-5(4H)-ones derivatives catalyzed magnetic deep eutectic solvent is reported. The structure of the nano-catalyst was characterized by FE-SEM, FT-IR, EDX, and TGA. Then, the excellent activity of the catalyst was displayed for the synthesis of 3,4-disubstituted isoxazole-5(4H)-ones derivatives. This heterogeneous catalyst can be easily recovered via a magnetic eld and reused for subsequent reactions. Easy workup, high yields in a short time and non-toxic catalyst are the main merits of this method.