The present paper deals with an application of Jacobi polynomial and multivariable Aleph-function to solve the differential equation of heat conduction in non-homogeneous moving rectangular parallelepiped. The temperature distribution in the parallelepiped, moving in a direction of the length (x-axis) between the limits x = −1 and x = 1 has been considered. The conductivity and the velocity have been assumed to be variables. We shall see two particular cases and the cases concerning Aleph-function of two variables and the I-function of two variables.