Green seaweed Enteromorpha compressa ( Chlorophyta , Ulvaceae ) derived sulphated polysaccharides inhibit herpes simplex virus

Lopes, Nayara; Ray, Sayani; Espada, Samantha Fernandes; Bomfim, Weslei Andrade; Ray, Bimalendu; Faccin-Galhardi, Lígia Carla; Linhares, Rosa Elisa Carvalho; Nozawa, Carlos

doi:10.1016/j.ijbiomac.2017.04.043

Cited by 91 publications

(57 citation statements)

References 67 publications

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“…HSV-1 IC 50 21.7 µg/mL, SI > 23 Chemically altered-sulfated ulvan Broad mechanism of action. [94] Sulfated fucoidans (S1-S3) from marine brown alga Padina tetrastomatica Vero cells, HSV-1 (strains F and B2006), HSV-2 (strain MS) PRA Virucidal assay Effect of treatment period on the antiviral activity HSV-1 and HSV-2 with IC 50 in range of 0.30-1.05 µg/mL B2006 S3 IC 50 0.6 µg/mL…”

Section: N-benzoyl-(2 R3 S)-3 -Phenylisoserine (114)mentioning

confidence: 99%

Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development

Treml

Gazdová

Šmejkal

et al. 2020

Viruses

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Recently, the problem of viral infection, particularly the infection with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), has dramatically increased and caused a significant challenge to public health due to the rising problem of drug resistance. The antiherpetic drug resistance crisis has been attributed to the overuse of these medications, as well as the lack of new drug development by the pharmaceutical industry due to reduced economic inducements and challenging regulatory requirements. Therefore, the development of novel antiviral drugs against HSV infections would be a step forward in improving global combat against these infections. The incorporation of biologically active natural products into anti-HSV drug development at the clinical level has gained limited attention to date. Thus, the search for new drugs from natural products that could enter clinical practice with lessened resistance, less undesirable effects, and various mechanisms of action is greatly needed to break the barriers to novel antiherpetic drug development, which, in turn, will pave the road towards the efficient and safe treatment of HSV infections. In this review, we aim to provide an up-to-date overview of the recent advances in natural antiherpetic agents. Additionally, this paper covers a large scale of phenolic compounds, alkaloids, terpenoids, polysaccharides, peptides, and other miscellaneous compounds derived from various sources of natural origin (plants, marine organisms, microbial sources, lichen species, insects, and mushrooms) with promising activities against HSV infections; these are in vitro and in vivo studies. This work also highlights bioactive natural products that could be used as templates for the further development of anti-HSV drugs at both animal and clinical levels, along with the potential mechanisms by which these compounds induce anti-HSV properties. Future insights into the development of these molecules as safe and effective natural anti-HSV drugs are also debated.

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Section: N-benzoyl-(2 R3 S)-3 -Phenylisoserine (114)mentioning

confidence: 99%

Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development

Treml

Gazdová

Šmejkal

et al. 2020

Viruses

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“…Sulfated polysaccharides from green algae such as Ulvan , Enteromorpha , and Monostroma were reported to possess potential antiviral activities against different viruses such as IAV and HSV . Komatsu et al reported that an acidic polysaccharide purified from green alga Coccomyxa gloeobotrydiformi exhibited anti‐IAV activity through preventing interactions between virus and host cells .…”

Section: Potential Antiviral Agents Derived From Marine Glycansmentioning

confidence: 99%

“…Komatsu et al reported that an acidic polysaccharide purified from green alga Coccomyxa gloeobotrydiformi exhibited anti‐IAV activity through preventing interactions between virus and host cells . Lopes and coworkers reported that a sulfated polysaccharide from Enteromorpha compressa showed significant anti‐HSV‐1 activity primarily by affecting viral replication . The polysaccharides from Monostroma latissimum possessed potent antiviral activities against HSV‐2 and HIV and mainly inhibited HSV‐2 adsorption and penetration processes .…”

Section: Potential Antiviral Agents Derived From Marine Glycansmentioning

confidence: 99%

Marine glycan–based antiviral agents in clinical or preclinical trials

et al. 2019

Reviews in Medical Virology

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The constant outbreak of diseases caused by viral infections has caused serious harm to human health all over the world. Although many antiviral drugs have been approved for clinical use during the past decade, important issues, such as unsatisfactory efficacy, toxicity, and high cost of drugs, remain unresolved. Glycans are major components of the surfaces of both host cells and most viruses and play critical roles in the steps of viral infection. Marine glycans have more structural diversities than those found in humans. Most importantly, low toxicity and low-cost marine glycans have demonstrated potent antiviral activities through multiple molecular mechanisms. As a result, a series of marine glycan-derived agents are undergoing preclinical and clinical trials. This review discusses the recent progress in research on the marine glycan-based antiviral agents in clinical trials, relating to their structural features and clinical applications. In addition, molecular mechanisms of marine glycans involved in viral infection and novel strategies used in glycan-based drug development are critically reviewed and discussed. KEYWORDS antiviral activities, clinical trials, heparinoids, marine glycans, virus entry 1 | INTRODUCTION During the past decade, the number of antiviral drugs approved for clinical use has increased from five to more than 30, 1 but major issues with efficacy, toxicity, and cost remain unresolved. 2 Hence, the development of better antiviral agents that can address these antiviral drug issues is of high importance. Glycans are major components of the surface of both host cells and most pathogens such as bacteria and viruses. It is well established that most interactions of microbial pathogens with their hosts are influenced by the pattern of their glycans and glycan-binding receptors. 3 Glycans such as negatively charged heparins can interfere with the virus entry process through masking the positive charge of the pathogen surface receptors to prevent them from binding to host cell surface heparan sulfate proteoglycans. 4 Marine glycans, especially those from seaweed, have many advantages as antiviral drug candidates, such as relatively low production costs, low cytotoxicity, and wide availability. 2 Thus, marine glycans are attractive candidates for developing potential antiviral agents and have attracted great academic and industrial interest.This review presents an overview of recent progress in research on the marine glycan-based antiviral agents in clinical trials, relating to their structure features and clinic applications, focusing on potential antiviral agents derived from the heparinoids. Recent developments in the roles of glycans in viral infection and novel glycan-based therapeutic strategies will also be discussed.

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“…They observed that the compounds with higher sulfate content and lesser substitution of xylose with a greater molecular mass depicted more anti-HSV effect [72]. Anti-HSV effect of seven chemically altered polysaccharides, obtained from Enteromorpha compressa (Linnaeus) Nees, has been evaluated; out of these seven compounds, one derivative, namely SU1F1, which was a 22% (w/w) sulfated heteroglycuronan, exhibited acceptable inhibitory effect on the virus through a wide-ranging mechanism of action [73]. Sulfated polysaccharide fraction isolated from Caulerpa racemosa (Forsskål) J. Agardh was considered to be a selective inhibitor of thymidine kinase (TK) acyclovir-resistant HSV-1 and HSV-2 strains in Vero cells and reference strains with EC 50 of approximately 2.2-4.2 µg/mL [60].…”

Section: Green Algaementioning

confidence: 99%

“…Caulerpa brachypus SP-rhamnan type and galactan type 1.9 (rhamnan type) & 0.65 (galactan type) - [115] Caulerpa okamurai SP-galactan type 0.55 - [115] Caulerpa racemosa SP fractions 4.2 3.0 [116] Caulerpa scapelliformis SP-galactan type 1.6 -Chaetomorpha crassa SP-arabinoxylogalactan type 0.85 - [115] Chaetomorpha spiralis SP-arabinoxylogalactan type 1.9 - [115] Codium fragile SP-arabinan type 0.86 - [115] Codium latum SP-arabinan type 0.38 - [115] Enteromorpha compressa sulphated heteroglycuronan 28.2 - [73] Monostroma nitidum SP-rhamnan type 0.4 - [115] Red Algae…”

Section: Green Algaementioning

confidence: 99%

Marine Algae: A Potential Resource of Anti-HSV Molecules

et al. 2019

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Herpes simplex viruses (HSVs) are common human pathogens belonging to the subfamily alpha-herpesvirinae that trigger severe infections in neonates and immunocompromised patients. After primary infection, the HSVs establish a lifelong latent infection in the vegetative neural ganglia of their hosts. HSV infections contribute to substantial disease burden in humans as well as in newborns. Despite a fair number of drugs being available for the treatment of HSV infections, new, effective, and safe antiviral agents, exerting different mechanisms of action, are urgently required, mainly due to the increasing number of resistant strains. Accumulating pieces of evidence have suggested that structurally diverse compounds from marine algae possess promising anti-HSV potentials. Several studies have documented a variety of algal polysaccharides possessing anti-HSV activity, including carrageenan and fucan. This review aimed to compile previous anti-HSV studies on marine algae–derived compounds, especially sulfated polysaccharides, along with their mode of action, toward their development as novel natural anti-HSV agents for future investigations.

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Green seaweed Enteromorpha compressa ( Chlorophyta , Ulvaceae ) derived sulphated polysaccharides inhibit herpes simplex virus

Cited by 91 publications

References 67 publications

Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development

Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development

Marine glycan–based antiviral agents in clinical or preclinical trials

Marine Algae: A Potential Resource of Anti-HSV Molecules

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