Green solvents and approaches recently applied for extraction of natural bioactive compounds

Hashemi, Beshare; Shiri, Fereshteh; Švec, František; Nováková, Lucie

doi:10.1016/j.trac.2022.116732

Cited by 47 publications

(15 citation statements)

References 104 publications

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“…In this scenario, great efforts are directed toward the identification of low-impact yet effective extraction media . Among them, deep eutectic solvents, especially natural ones, are gaining increasing attention thanks to their ability to exert a multitude of interactions, which favor the solubility and mass transfer of targeted molecules. ,, …”

Section: Resultsmentioning

confidence: 99%

Pine Needles as a Biomass Resource for Phenolic Compounds: Trade-Off between Efficiency and Sustainability of the Extraction Methods by Life Cycle Assessment

Luna

Vetrone

Viggiano

et al. 2023

ACS Sustainable Chem. Eng.

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Polyphenols are natural organic compounds with many possible applications because of their unique biological activities. They can be extracted from a wide variety of waste biomasses, and a great deal of interest exists in identifying extraction processes optimized in terms of both yield and environmental impact. In this framework, we have compared three techniques, namely, maceration and extraction assisted by either ultrasounds or microwaves, for the extraction of phenolic compounds from dry pine needles, largely available and underexploited biomass. The yields in terms of total phenolic compounds and condensed tannins were assessed as a function of the extraction time, and a life cycle assessment (LCA) approach was adopted for quantifying the environmental impacts of the three techniques. Despite being time-consuming, maceration is the least-impact method, immediately followed by (much faster) ultrasound-assisted extraction. The energy intensity is mainly responsible for the overall eco-profile of the three techniques, whose hotspot resulted to be electricity consumption. Short processing time is hence crucial, as the gains in terms of yield achievable by prolonging the extraction processes bring about energy burdens that nullify the environmental advantages. Even the choice of "greener" solvents (e.g., ethanol instead of acetone) appeared questionable, as the extraction yield has an impact greater than the "greenness" of the raw materials.

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Section: Resultsmentioning

confidence: 99%

Pine Needles as a Biomass Resource for Phenolic Compounds: Trade-Off between Efficiency and Sustainability of the Extraction Methods by Life Cycle Assessment

Luna

Vetrone

Viggiano

et al. 2023

ACS Sustainable Chem. Eng.

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“…Using such solvent systems, the use of noxious organic solvents used for extraction purposes can be minimized. [16,17] Using these solvent systems, extraction yield was found to be increased as compared to the yield by use of ethanol. In evaluation studies such as in vitro, the drug permeation was also similar or more than drug release studies of some of the reported formulation consisting curcumin.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2022

AJP

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Background: Since the beginning of time, humankind has employed herbal and medicinal plants as a source of food and medicine. Plant bioactive chemicals are currently of great research interest. However, extracting them as part of phytochemical and/or biological studies brings unique problems. Many techniques for the extraction of bioactive components have been devised by herbalists or scientists to indemnify the effectiveness and efficacy of the raw medications used to treat illness. The mode of extraction of active phytochemicals is receiving a lot of attention to reduce the costs associated with synthesis and separation. As a result, the extraction of active compounds from plants requires a proper procedure for extraction and techniques that provide extracts and fractions high in bioactive components, and also the solvents used in extraction do not harm humans as well as nature. As a result, they have a significant impact on yield, the nature of phytochemical content, and so on. Objectives: The purpose of this paper is to discuss and describe that solvents for extraction which shall be ecofriendly, safe, and also can be recovered easily by evaporation and preparation of the formulation using blends derived by idea of mixed solvency concept. Materials and Methods: Before extraction and formulation purity, tests were done on turmeric powder. Then, extraction was done using solvents prepared using mixed solvency such as camphor in ethanol (25% w/v and 50% w/v) and thymol in ethanol (25% w/v and 50% w/v). In addition, identification tests were done on the obtained extract. The comparative study was done on extraction yields, to establish a comparison between the yield obtained using conventional solvent and solvents prepared using the mixed solvency concept. In addition to that, a topical formulation was also prepared for the obtained extract. For formulation development solubility, studies of turmeric extract were done in various oils, ethanol, and blends (constituted in ethyl oleate with the combination of additives such as methyl paraben, propyl paraben, glyceryl monostearate, benzyl benzoate, and benzoic acid). The formulation so formed was a 0.9% curcumin oily solution and the evaluation tests such as viscosity, drug excipients interaction studies, and in vitro release studies were also done for the same. Results: In the extraction, it was discovered that adding camphor and thymol to ethanol improves the yield of turmeric extract, as compared to ethanol. Solubility studies were done for the preparation of topical solution and topical emulgel. The maximum solubility of turmeric extract was perceived in an oily blend which was formed by the purport of the mixed solvency concept). As a result, the oil base chosen for the formulation was an oily blend rather than a single oil or ethanol. In which the formulation produced positive outcomes. Evaluation studies such as freeze thaw, in vitro drug release, and antibacterial activity were performed for the formulation and it showed virtuous results.

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“…Hydrophilic or hydrophobic DESs can be easily prepared depending on the chemical structures of the hydrogen bond acceptor (HBA) and hydrogen bond donor (HBD) employed. Several studies − have shown DESs to be effective solvents for the extraction of natural compounds from matrices of vegetal origin prior to downstream chromatographic analysis. Plants are complex samples characterized by several compounds belonging to different chemical classes, divided into primary (e.g., amino acids and polysaccharides) and secondary (e.g., terpenes and phenolics) metabolites .…”

Section: Introductionmentioning

confidence: 99%

New Class of Tunable Choline Bromide-Based Hydrophobic Deep Eutectic Solvents for the Extraction of Bioactive Compounds of Varying Polarity from a Plant Matrix

Mastellone

Abbasi

Cagliero

et al. 2023

ACS Sustainable Chem. Eng.

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Deep eutectic solvents (DESs) are a class of sustainable solvents that have found numerous applications in different fields. One of their main attributes is the possibility of easily modifying their physicochemical properties by varying the type of hydrogen bond donor (HBD) and hydrogen bond acceptor (HBA) that comprise them. Choline chloride ([Ch + ][Cl − ])-based hydrophilic DESs were among the first studied and the most used because of their capacity to easily create a hydrogen bonding network that lies in its unique chemical structure, characterized by a hydroxyl substituent within the ammonium headgroup. In this study, a new class of hydrophobic [Ch + ][Br − ]-modified salts were synthesized to produce HBAs with similar properties to choline for the preparation of hydrophobic DESs. Six different [Ch + ][Br − ]-based HDESs were prepared and characterized in terms of hydrophobicity, viscosity, and solvation properties (hydrogen bonding, dispersion, dipolarity/polarizability, n−π, and π−π interactions). They were employed as solvents in a microextraction method for the determination of phytochemicals in Cannabis sativa L. plant. The extraction performance of the [Ch + ][Br − ]-based HDESs was compared to eutectic mixtures based on conventional hydrophobic HBAs, and the results revealed that the unique properties of [Ch + ][Br − ]-modified salts allowed for the extraction of both hydrophilic (i.e., flavonoids) and hydrophobic compounds (i.e., cannabinoids).

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Green solvents and approaches recently applied for extraction of natural bioactive compounds

Cited by 47 publications

References 104 publications

Pine Needles as a Biomass Resource for Phenolic Compounds: Trade-Off between Efficiency and Sustainability of the Extraction Methods by Life Cycle Assessment

Pine Needles as a Biomass Resource for Phenolic Compounds: Trade-Off between Efficiency and Sustainability of the Extraction Methods by Life Cycle Assessment

Untitled

New Class of Tunable Choline Bromide-Based Hydrophobic Deep Eutectic Solvents for the Extraction of Bioactive Compounds of Varying Polarity from a Plant Matrix

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