2022
DOI: 10.1039/d1ob01814k
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Green solvents for the formation of amide linkages

Abstract: Green solvents as alternatives for cleaner and safer amide synthesis.

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Cited by 36 publications
(24 citation statements)
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References 118 publications
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“…Furthermore, existing amidation protocols in organic solvents are not ideal alternatives either, as these protocols often use hazardous and unsustainable solvents such as dimethylformamide, N -methylpyrrolidon, or dichloromethane. The use of these solvents is currently considered one of the main issues in amidation reactions, emphasizing the importance of the use of alternative, greener solvents [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, existing amidation protocols in organic solvents are not ideal alternatives either, as these protocols often use hazardous and unsustainable solvents such as dimethylformamide, N -methylpyrrolidon, or dichloromethane. The use of these solvents is currently considered one of the main issues in amidation reactions, emphasizing the importance of the use of alternative, greener solvents [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…To sum up, Cyrene seems to be a plausible solvent for peptide chemistry, but further research ought to be done, considering the synthesis of larger peptides and their purification. 35…”
Section: Cyrene In Organic Chemistrymentioning
confidence: 99%
“…A formação de ligações amida está entre as mais realizadas em indústrias químicas e farmacêuticas (PROCOPIO et al, 2022). Devido à sua grande aplicação, principalmente para produção de medicamentos, diversos métodos são estudados para sua obtenção (NI et al, 2022).…”
Section: Proposta De Mudança Da Rota De Sínteseunclassified