Green solvents tailored nanostructures of block copolymers and their potential applications in drug delivery

Kumar, Ambrish; Saha, Moumita; Vishwakarma, Ritik; Behera, Kamalakanta; Trivedi, Shruti

doi:10.1016/j.molliq.2024.125642

Journal of Molecular Liquids

2024

DOI: 10.1016/j.molliq.2024.125642

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Green solvents tailored nanostructures of block copolymers and their potential applications in drug delivery

Ambrish Kumar,

Moumita Saha,

Ritik Vishwakarma

et al.

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Cited by 3 publications

References 316 publications

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Emerging Applications of Smart Hydrogel Nanocomposites in 3D Printing

Heidari,

Shahi,

Afshar

et al. 2024

Polymers for Advanced Techs

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This review provides a comprehensive overview of the emerging applications of stimuli‐responsive hydrogels in 3D printing, emphasizing their transformative potential in creating adaptive and multifunctional structures. Stimuli‐responsive hydrogels, including magneto‐, thermo‐, pH‐, moisture‐, solvent‐, and photo‐responsive varieties, have gained significant attention due to their ability to undergo dynamic changes in response to specific environmental stimuli. The review begins by exploring the fundamental characteristics and fabrication methods of hydrogels used in additive manufacturing, highlighting their exceptional adaptability and programmability. It then delves into various applications across diverse fields, including soft robotics, tissue engineering, drug delivery systems, wearable electronics, food technology, electromagnetic interference shielding, and anti‐counterfeiting technologies. By integrating the latest advancements in 3D printing techniques, this review aims to offer insights into how stimuli‐responsive hydrogels are enabling the development of innovative, intelligent, and environmentally responsive systems. The future perspectives section discusses challenges and opportunities for advancing the use of hydrogels in 3D printing, suggesting directions for future research that could push the boundaries of functional materials and programmable structures.

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Emerging Applications of Smart Hydrogel Nanocomposites in 3D Printing

Heidari,

Shahi,

Afshar

et al. 2024

Polymers for Advanced Techs

View full text Add to dashboard Cite

show abstract

Development and evaluation of a pH-sensitive, naturally crosslinked alginate-chitosan hydrogel for drug delivery applications

Khatibi,

Naimi-Jamal,

Balalaie

et al. 2024

Front. Biomater. Sci.

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The development of safe and efficient delivery systems for targeted and controlled release of therapeutic agents has become a major focus in pharmacotherapy. The colon is one organ that serves as an optimal site for the absorption of protein and peptide drugs, offering significant potential for both localized and systemic therapies. However, effective drug delivery is challenged by the need to protect these drugs from premature absorption and maintain their stability across the varying pH levels of the gastrointestinal tract. In this study, we introduce, for the first time, a fully natural hydrogel system composed of N-acetylated chitosan and alginate, crosslinked using a phenylalanine-phenylalanine dipeptide. The hydrogel demonstrates a unique swelling behavior, allowing for a solvent-free drug-loading method and pH-sensitive release properties. In a colon-simulated pH environment, the hydrogel achieved a high drug release efficiency, with 77.6% of the tested drug sulfasalazine and 51% of hydrocortisone over 5 hours. These findings underscore hydrogel’s potential as a promising drug delivery carrier for targeted gastrointestinal treatments, with the capacity to enhance the efficacy of current therapeutic options.

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Nanostructured Drug Delivery Systems in Immunotherapy: An Updated Overview of Nanotechnology-Based Therapeutic Innovations

Croitoru,

Niculescu,

Epistatu

et al. 2024

Applied Sciences

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Using nanostructured drug delivery systems has attracted increasing interest in immunotherapeutic approaches. The intrinsic immunomodulatory properties and versatility of nanoparticles used as carriers were consistently reported to augment treatment efficiency as nanoscaled materials increase drug accumulation at the desired site, enhance cell internalization, and improve therapeutic outcomes. Thus, numerous studies have exploited the potential use of nanostructured drug delivery vehicles in delivering different cargo as a promising alternative for treating conditions like cancer, autoimmune diseases, infectious diseases, and allergic and immune disorders. In this context, this paper presents nanostructured drug delivery systems as a solid basis for immunotherapeutic innovations, highlighting their advantages for improving treatment strategies, reviewing their clinical applications, and discussing existing challenges and ways to overcome them.

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Green solvents tailored nanostructures of block copolymers and their potential applications in drug delivery

Cited by 3 publications

References 316 publications

Emerging Applications of Smart Hydrogel Nanocomposites in 3D Printing

Emerging Applications of Smart Hydrogel Nanocomposites in 3D Printing

Development and evaluation of a pH-sensitive, naturally crosslinked alginate-chitosan hydrogel for drug delivery applications

Nanostructured Drug Delivery Systems in Immunotherapy: An Updated Overview of Nanotechnology-Based Therapeutic Innovations

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