Green Solvents to Value Annona muricata L. Leaves as Antioxidants Source: Process Optimization and Potential as a Natural Food Additive

Leal, Fernando Castro; Farias, Fabiane Oliveira; Amaral, Wanderlei do; Toci, Aline Theodoro; Mafra, Marcos R.; Igarashi‐Mafra, Luciana

doi:10.1007/s12649-021-01581-0

Cited by 7 publications

(9 citation statements)

References 44 publications

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“…In this study, the TSP values from aqueous UAE extract were three times greater than the soluble phenols reported as gallic acid equivalents from aqueous extracts by stirring (68.37 mg/100 mL), maceration (26.2 mg/g of extract), and ultrasonic bath (42 mg/g of extract) from A. muricata leaves, [6,17,35]. It is attributed to the direct contact of the ultrasonic probe with the samples, which generate high-intensity ultrasonic waves.…”

Section: Total Soluble Phenols and Yield From A Muricata Leaves By Ul...mentioning

confidence: 56%

“…Lee et al [16] demonstrated that alkaloids extraction from A. muricata leaves by a digital ultrasonic bath (280 W, 30 min, 47 • C) combined with a stirrer promoted a considerable yield of alkaloids and antioxidant activity compared to Soxhlet extraction. Recently, Leal et al [17] extracted the highest content of phenolic compounds (~42 mg/g) from A. muricata leaves using UAE (45 • C, 2 h). However, the authors failed to mention the power of the ultrasonic application.…”

Section: Introductionmentioning

confidence: 99%

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Annona muricata Leaves as a Source of Bioactive Compounds: Extraction and Quantification Using Ultrasound

et al. 2022

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In this work, the ultrasound-assisted extraction (UAE) (operating conditions of sonication amplitude, pulse-cycle, and extraction time) was investigated to obtain an extract rich in biologically active compounds from Annona muricata leaves. In addition, the content of bioactive compounds from the extract by the optimal UAE conditions (UAE extract) was compared with extracts prepared by decoction and infusion. Moreover, Artemia salina toxicity was evaluated in all extracts. UAE extract (using optimal conditions: 80% amplitude, 0.7 s pulse-cycle, for 4.54 min) contained 178.48 mg/100 mL of soluble phenols, 20.18 mg/100 mL of total flavonoids, 27.81 mg/100 mL of hydrolyzable polyphenols, 167.07 mg/100 mL of condensed tannins, 30.44 mg/100 mL of total alkaloids and 14.62 mg/100 mL of total acetogenins. The UAE extract exhibited a high antioxidant capacity and a higher content of bioactive compounds from ~6 to ~927-fold than decoction or infusion, depending on the type of compound. Twenty-four different phenolic compounds were identified in the samples, and UAE extract produced the highest concentration. All extracts were considered non-toxic using the A. salina test. The UAE extract from A. muricata leaves is a rich source of bioactive compounds and can be utilized to formulate therapeutic drugs or nutraceutical foods.

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Section: Total Soluble Phenols and Yield From A Muricata Leaves By Ul...mentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Annona muricata Leaves as a Source of Bioactive Compounds: Extraction and Quantification Using Ultrasound

et al. 2022

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“…This procedure was applied to the three lemongrass species, in triplicate, totaling 72 samples. To select the optimal solvents, antioxidant activity analysis (DPPH and FRAP) and TPC were employed (Leal et al, 2022; Oliveira et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

“…To select the optimal solvents, antioxidant activity analysis (DPPH and FRAP) and TPC were employed (Leal et al, 2022;Oliveira et al, 2021).…”

Section: Reagentsmentioning

confidence: 99%

Bioactive compounds extraction from different lemongrass species: Strategies and deep eutectic solvents evaluation

Toazza

Leal

Marques

et al. 2022

J Food Process Engineering

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Lemongrasses are known and used worldwide due to several benefits conferred to them regarding the high content of essential oils and other phenolic compounds, which are essential and nonessential compounds that occur in nature, are part of the food chain and present several benefits on human health. The obtaining of phenolic compounds from natural matrices requires the development of effective processes with minor impacts on the environment and target compounds. In this work, green solvents entitled deep eutectic solvents (DES) were evaluated against conventional solvents, as acetone, ethanol, and methanol, to obtain phenolic compounds from three different species of lemongrasses (Cymbopogon flexuosus, Cymbopogon citratus, and Elyonurus muticus). The best extraction conditions were determined into three completely random designs (CRD). The first CRD aimed at solvent selection, for this the extraction conditions were fixed in 45°C/2 hr. The second CRD was to determine the optimum process temperature. And finally, the last CRD compared different methods of extraction: magnetic stirring, Ultra‐Turrax, and ultrasound assisted extraction. The extraction kinetics were also obtained. The experimental results indicated that the extract from lemongrass C. citratus presented higher content of phenolic compounds using the DES composed of cholinium chloride and acetic acid as solvent, employing magnetic stirring at 60°C by 180 min. Moreover, all the DES‐based extracts presented higher antioxidant, iron chelating, and antimicrobial capacities than the traditional solvents. Therefore, the DES showed suitable capacity for extraction, and maintenance of phenolic compounds from lemongrasses, superior to those traditional solvents, being a promising alternative for use in medical, pharmaceutical, and food industries.Practical ApplicationsThe research uses different solvents and mechanisms to extract biocompounds, as essential oils and phenolic compounds from lemongrass species. The higher extraction conditions, in terms of solvent, time and extraction method, showed higher antioxidant activity, antimicrobial potential, and iron chelating capacity, which in interest to enrich food, improve cosmetics, clean waste water and residues. Also, there were identified several bioactive compounds from lemongrass, as citral. DES employment is an innovative extraction solvent, and can present low cost and nontoxic approach enhancing extraction efficiency of bioactive compounds.

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“…To evaluate the capacity of DES to preserve and stabilize the obtained bioactive compounds, thermal stability was assessed in TPC and DPPH, which have been widely applied to evaluate the thermal degradation stability of antioxidant compounds. [45][46][47][48] The proposed equation (Equation ( 1)) has been widely applied to quantify the effect of temperature on the rate of several chemical and biochemical reactions. [45,46] Also, the DES-based extracts were compared with extracts obtained using conventional solvents (water and ethanol) in the same process conditions (150 min, 65 C, and 1:30 m/v).…”

Section: Thermal Stabilitymentioning

confidence: 99%

Optimization of green extraction of high‐value components from Eugenia uniflora leaves: Thermal stability and in‐vitro biological activity

et al. 2022

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Deep eutectic solvents (DES) were evaluated as a sustainable route to obtain bioactive compounds from Eugenia uniflora L. leaves (EUL). Completely randomized experimental designs determined the process conditions. The DES composed of cholinium chloride as hydrogen bond acceptor (HBA) and lactic acid, glycerol, or 1,2‐propanediol as hydrogen bond donor (HBD) showed the best extraction capacity. The better conditions were 150 min, 65°C, and a solid:liquid ratio of 1:30. The major constituents of the extracts, quantified by high‐performance liquid chromatography (HPLC), were naringin and caffeic acid. Moreover, the DES promoted a preservative effect on the EUL extracts against thermal treatments. All extracts exhibited high antioxidant and antiglycation activities and iron‐chelating potential. Moreover, when lactic acid was the HBD, the extracts showed considerable antibacterial activity. Therefore, it was effectively proposed as an effective and green route to obtain extracts with potential applications in the food, cosmetic, and pharmaceutical industries.

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Green Solvents to Value Annona muricata L. Leaves as Antioxidants Source: Process Optimization and Potential as a Natural Food Additive

Cited by 7 publications

References 44 publications

Annona muricata Leaves as a Source of Bioactive Compounds: Extraction and Quantification Using Ultrasound

Annona muricata Leaves as a Source of Bioactive Compounds: Extraction and Quantification Using Ultrasound

Bioactive compounds extraction from different lemongrass species: Strategies and deep eutectic solvents evaluation

Optimization of green extraction of high‐value components from Eugenia uniflora leaves: Thermal stability and in‐vitro biological activity

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