Green sweat: an atypical finding in drug‐induced liver disease

Narciso-Schiavon, Janaína Luz; Giunta, Gabriella Di; André, Mariana H.; Dimatos, Oscar Cardoso; Dantas-Corrêa, Esther Buzaglo; Nunes, Daniel Holthausen; Schiavon, Leonardo Lucca

doi:10.1111/liv.12449

Cited by 2 publications

(5 citation statements)

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“…A 6-month-old patient presented with drug-abused cholestasis accompanied with jaundice, presenting with high levels of direct bilirubin that was secreted through the eccrine gland. Moreover, biopsy results showed dilated eccrine pores and a positive Prussian blue stain [3]. Previous reports consider this bilirubin excretion by the eccrine glands as exceptional variants of eccrine chromhidrosis.…”

Section: Vol 4 | Issue 4 | Jul -Aug 2018mentioning

confidence: 63%

“…Disease-related eccrine chromhidrosis causes hyperbilirubinemia, which can be primary or secondary to cholangiocarcinoma [1], liver cirrhosis [2], drug-induced liver disease [3], and enterococcal bacteremia [4]. Progressive jaundice induced by advanced intrahepatic cholangiocarcinoma causes an elevated level of direct bilirubin which led to increased secretions of water-solute bilirubin from the eccrine glands [1].…”

Section: Vol 4 | Issue 4 | Jul -Aug 2018mentioning

confidence: 99%

“…Eccrine chromhidrosis is an exceedingly rare condition where water-soluble pigments are secreted through eccrine sweat glands. Increased bilirubin in hyperbilirubinemia, secondary to liver diseases, was reported in the previous literature [1][2][3][4]. The most common extrinsic causes of this disorder are dyes and/ or pigment(s) ingestion from medication (tartrazine-coated bisacodyl [5] and homeopathy drug [6]) or diet (tomato-flavored prepacked food [7]).…”

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confidence: 99%

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Eccrine Chromhidrosis: A Case Report and Review of Literature

Xu¹,

Qiao²,

Fang³

2018

IJCR

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Chromhidrosis is a rare disorder characterized by colored sweat and/or stained skin. Eccrine chromhidrosis is an orphan disease in which water-soluble pigments are excreted through the eccrine glands. This article provides a highly doubtful eccrine chromhidrosis case and the literature review for eccrine chromhidrosis. We recommend an investigative algorithm for dermatologists, hepatologist, and general practitioners to enhance diagnostic capability without mistake among similar and differential diseases. Most importantly, the exact etiology should be determined, which further decides the treatment plan. Systemic treatment of liver diseases or bacteremia was reported particularly effective. Results and prognosis were excellent and without recurrence.

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Section: Vol 4 | Issue 4 | Jul -Aug 2018mentioning

confidence: 63%

Section: Vol 4 | Issue 4 | Jul -Aug 2018mentioning

confidence: 99%

mentioning

confidence: 99%

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Eccrine Chromhidrosis: A Case Report and Review of Literature

Xu¹,

Qiao²,

Fang³

2018

IJCR

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“…Since the patient came to us with empty bottles of the medicine, we could not analyze the composition of the same, which is a limitation of this report. Green colored sweating may also occur rarely in a patient with liver failure or hyperbilirubinemia [3,10]. Triwongwaranat et al reported a case of green eccrine chromhidrosis in patient with advanced intrahepatic cholangiocarcinoma and progressive jaundice [8].…”

Section: Discussionmentioning

confidence: 99%

“…Triwongwaranat et al reported a case of green eccrine chromhidrosis in patient with advanced intrahepatic cholangiocarcinoma and progressive jaundice [8]. Brown-colored direct bilirubin is secreted through the eccrine glands, converted to green-colored biliverdin by oxidative processes giving rise to green sweat in those patients [10].…”

Section: Discussionmentioning

confidence: 99%