Green synthesis and biological activities of silver nanoparticles prepared by Carpesium cernuum extract

Ahn, Eun-Young; Park, Youmie

doi:10.1007/s12272-019-01152-x

Cited by 28 publications

(19 citation statements)

References 26 publications

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“…There are other methods based on the same principle, in which the salts are soluble in water. The MTS assay uses the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2- (4-sulfophenyl)-2H-tetrazolium salt or soluble tetrazolium (WST), which has the advantage of no longer requiring the use of a solubilizer such as dimethyl sulfoxide (DMSO) [ 105 , 106 , 107 ]. Cell viability has also been determined with methods based on evaluating the integrity of the plasmatic membrane.…”

Section: Cancer Evaluation Modelsmentioning

confidence: 99%

“…Most designs that seek to evaluate the effectiveness of new selective molecules or treatments against cancer include some controls, which, in most cases, comprise a cancer model cell line and a non-cancerous control [ 115 , 116 , 117 ]. When the purpose is to demonstrate that the toxic activity results from the association of the biogenic NP, it is imperative also to test the toxicity of the NP-free plant extract and determine how much of the effect is attributed solely to the extract [ 103 , 105 , 118 ].…”

Section: Cancer Evaluation Modelsmentioning

confidence: 99%

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Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications

et al. 2021

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Metal-based nanoparticles are widely used to deliver bioactive molecules and drugs to improve cancer therapy. Several research works have highlighted the synthesis of gold and silver nanoparticles by green chemistry, using biological entities to minimize the use of solvents and control their physicochemical and biological properties. Recent advances in evaluating the anticancer effect of green biogenic Au and Ag nanoparticles are mainly focused on the use of conventional 2D cell culture and in vivo murine models that allow determination of the half-maximal inhibitory concentration, a critical parameter to move forward clinical trials. However, the interaction between nanoparticles and the tumor microenvironment is not yet fully understood. Therefore, it is necessary to develop more human-like evaluation models or to improve the existing ones for a better understanding of the molecular bases of cancer. This review provides recent advances in biosynthesized Au and Ag nanoparticles for seven of the most common and relevant cancers and their biological assessment. In addition, it provides a general idea of the in silico, in vitro, ex vivo, and in vivo models used for the anticancer evaluation of green biogenic metal-based nanoparticles.

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Section: Cancer Evaluation Modelsmentioning

confidence: 99%

Section: Cancer Evaluation Modelsmentioning

confidence: 99%

Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications

et al. 2021

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“…Eun et al studied methanol extract of Carpesium cernuum for AgNP synthesis to determine the relationship between bioactive molecules and AgNP structures [ 73 ]. The reduction reaction was evaluated for its effects on yield, colloidal stability, size, and shape.…”

Section: Chinese Herbal Medicinementioning

confidence: 99%

“…To compare the bactericidal activity of AgNPs on clinical ultrasound gel, the commercial gel was contaminated with S. aureus , E. coli , P. aeruginosa , and Candida albicans ( C. albicans ), while no bacterial cross-contamination was observed on self-prepared AgNP (10 μg/mL) gel. However, the parameters and protocols used in various studies indicate that the antibacterial activity is largely dependent on the method of preparation, concentration, and particle size [ 73 ]. Additionally, the synthetic AgNPs exhibit strong antibacterial activity, which may be attributed to their small size and high surface area.…”

Section: Antimicrobial Properties Of Chinese Herbsmentioning

confidence: 99%

Biomedical Applications of Chinese Herb-Synthesized Silver Nanoparticles by Phytonanotechnology

2021

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Recent advances in nanotechnology have opened up new avenues for the controlled synthesis of nanoparticles for biomedical and pharmaceutical applications. Chinese herbal medicine is a natural gift to humanity, and it has long been used as an antibacterial and anticancer agent. This study will highlight recent developments in the phytonanotechnological synthesis of Chinese herbal medicines to utilize their bioactive components in biomedical and therapeutic applications. Biologically synthesized silver nanoparticles (AgNPs) have emerged as a promising alternative to chemical and physical approaches for various biomedical applications. The comprehensive rationale of combinational or synergistic effects of Chinese herb-based AgNPs synthesis was investigated with superior physicochemical and biological properties, and their biomedical applications, including antimicrobial and anticancer activity and wound healing properties. AgNPs can damage the cell ultrastructure by triggering apoptosis, which includes the formation of reactive oxygen species (ROS), DNA disintegration, protein inactivation, and the regulation of various signaling pathways. However, the anticancer mechanism of Chinese herbal medicine-based AgNPs is more complicated due to the potential toxicity of AgNPs. Further in-depth studies are required to address Chinese herbs’ various bioactive components and AgNPs as a synergistic approach to combat antimicrobial resistance, therapeutic efficiency of drug delivery, and control and prevention of newly emerged diseases.

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“…At the same time, their small size and other characteristics make them easy to penetrate cell membranes and play an advantage in immune response [5][6][7]. Among them, silver nanoparticles (AgNPs) have been favoured by many researchers for its excellent photoelectric properties and biological activities [8,9]. The research by Batoni et al [10] showed that AgNPs can effectively kill bacteria, viruses and eukaryotic microbes at low concentration with no toxicity on body; Sriram et al prepared AgNPs by reduction with Bacillus licheniformis.…”

mentioning

confidence: 99%

Green synthesis of silver nanoparticles from Lonicera japonica leaf extract and their anti‐inflammatory and antibacterial effects

Yan

Qiu

et al. 2020

Micro & Nano Letters

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A green synthesis of silver nanoparticles (AgNPs) using aqueous Lonicera japonica leaf extract (AgNPs-LLJ) was reported and their anti-inflammatory and antibacterial effects were investigated. In comparison, AgNPs were also synthesised using the liquid phase chemical reduction method (AgNPs-N 2 H 4 •H 2 O). The synthesised AgNPs were identified using multiple analytical techniques. The results showed that both AgNPs were spherical particles with an average particle size of 20-30 nm for AgNPs-LLJ and 10-20 nm for AgNPs-N 2 H 4 •H 2 O. The anti-inflammatory ability of AgNPs was shown by the effective inhibition against 5-lipoxygenase with IC 50 values of 5.08 μg/mL for AgNPs-LLJ and 59.12 μg/mL for AgNPs-N 2 H 4 •H 2 O, indicating that AgNPs-LLJ had much more obvious antiinflammatory effect. Furthermore, the cytotoxicity research on RAW264.7 mouse macrophages showed that AgNPs-LLJ had no cytotoxicity at the concentration of 40 μg/mL compared with control. Their antibacterial effects on Escherichia coli (EC) and Staphlococcus aureus (SA) were studied by agar well diffusion method. The maximum antibacterial circles of AgNPs-N 2 H 4 •H 2 O on EC and SA were 15 and 14 mm, respectively, whereas it was 5.0 and 5.0 mm for AgNPs-LLJ, respectively. The authors conclude that AgNPs-LLJs have a potential to be a nanomedicine for nanobiomedical applications.

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Green synthesis and biological activities of silver nanoparticles prepared by Carpesium cernuum extract

Cited by 28 publications

References 26 publications

Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications

Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications

Biomedical Applications of Chinese Herb-Synthesized Silver Nanoparticles by Phytonanotechnology

Green synthesis of silver nanoparticles from Lonicera japonica leaf extract and their anti‐inflammatory and antibacterial effects

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