Green synthesis and characterization of silicate nanostructures coated with Pluronic F127/gelatin for triggered drug delivery in tumor microenvironments

Mdlovu, Ndumiso Vukile; Juang, Ruey‐Shin; Lin, Kuen‐Song

doi:10.1016/j.ijbiomac.2023.126337

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…As a result of their research, it was concluded that the f mulated carriers exhibited high encapsulation efficiency (87.5%) and drug loading (45 Moreover, their developed systems also showed high stability and drug-release abil which was proven during their biological research. Cytotoxicity assay results dem strated the death of over 53% of tested cancer cells treated with the materials obtain Other researchers [163] received mesoporous silicate MCM-41-based nanocomposites ditionally coated with gelatin and Pluronic ® F127 and incorporated them with doxoru cin. These conducted studies confirmed the release capability of nanocomposites wher the process most effectively occurred in the environment with pH = 5.4 and at 42 °C.…”

Section: Gelatin-based Drug Carriersmentioning

confidence: 99%

“…Cytotoxicity assay results demonstrated the death of over 53% of tested cancer cells treated with the materials obtained. Other researchers [163] received mesoporous silicate MCM-41-based nanocomposites additionally coated with gelatin and Pluronic ® F127 and incorporated them with doxorubicin. These conducted studies confirmed the release capability of nanocomposites wherein the process most effectively occurred in the environment with pH = 5.4 and at 42 • C. Importantly, the formulated carriers showed cytotoxicity towards cancer cells.…”

Section: Gelatin-based Drug Carriersmentioning

confidence: 99%

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Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms

Jamroży,

Kudłacik-Kramarczyk,

Drabczyk

et al. 2024

IJMS

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Studies on bionanocomposite drug carriers are a key area in the field of active substance delivery, introducing innovative approaches to improve drug therapy. Such drug carriers play a crucial role in enhancing the bioavailability of active substances, affecting therapy efficiency and precision. The targeted delivery of drugs to the targeted sites of action and minimization of toxicity to the body is becoming possible through the use of these advanced carriers. Recent research has focused on bionanocomposite structures based on biopolymers, including lipids, polysaccharides, and proteins. This review paper is focused on the description of lipid-containing nanocomposite carriers (including liposomes, lipid emulsions, lipid nanoparticles, solid lipid nanoparticles, and nanostructured lipid carriers), polysaccharide-containing nanocomposite carriers (including alginate and cellulose), and protein-containing nanocomposite carriers (e.g., gelatin and albumin). It was demonstrated in many investigations that such carriers show the ability to load therapeutic substances efficiently and precisely control drug release. They also demonstrated desirable biocompatibility, which is a promising sign for their potential application in drug therapy. The development of bionanocomposite drug carriers indicates a novel approach to improving drug delivery processes, which has the potential to contribute to significant advances in the field of pharmacology, improving therapeutic efficacy while minimizing side effects.

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Section: Gelatin-based Drug Carriersmentioning

confidence: 99%

Section: Gelatin-based Drug Carriersmentioning

confidence: 99%