Green synthesis and characterization of copper nanoparticles using Phragmanthera austroarabica extract and their biological/environmental applications

Alahdal, Faiza A.M.; Qashqoosh, Mohsen T.A.; Manea, Yahiya Kadaf; Mohammed, Rafeeq K.A.; Naqvi, Saba

doi:10.1016/j.susmat.2022.e00540

Cited by 25 publications

(9 citation statements)

References 100 publications

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“…An F-2700 FL spectrophotometer with scan rate (1500 nm/min), EX slit 5 nm was used for synchronous and fluorescence studies. 47 UV−Vis measurements were recorded by a PerkinElmer U.V Win Lab 6.0.4.0738/1.61.00 Lambda 800 spectrometer. FT-IR analysis was performed in a moisture-free atmosphere using PerkinElmer electronic.…”

Section: Characterizationmentioning

confidence: 99%

“…All biophysical investigations were conducted with reproducibility and a standard deviation approach for obtained results. An F-2700 FL spectrophotometer with scan rate (1500 nm/min), EX slit 5 nm was used for synchronous and fluorescence studies . UV–Vis measurements were recorded by a PerkinElmer U.V Win Lab 6.0.4.0738/1.61.00 Lambda 800 spectrometer.…”

Section: Characterizationmentioning

confidence: 99%

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In Vitro Hemoglobin Binding and Molecular Docking of Synthesized Chitosan-Based Drug-Carrying Nanocomposite for Ciprofloxacin-HCl Drug Delivery System

Manea,

Qashqoosh,

Rezakazemi

2024

ACS Omega

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Understanding the intermolecular interactions between antibiotic drugs and hemoglobin is crucial in biological systems. The current study aimed to investigate the preparation of chitosan/polysorbate-80/tripolyphosphate (CS-PS/TPP) nanocomposite as a potential drug carrier for Ciprofloxacin-HCl drug (CFX), intended for controlled release formulation and further used to interact with bovine hemoglobin. Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis−differential thermal analysis (TGA-DTA), scanning electron microscopy (SEM), dynamic light scattering (DLS), and X-ray diffraction analyses were used to characterize the CS-PS/TPP nanocomposite and its CFX-loaded nanocomposite. The second series of biophysical properties were performed on the Ciprofloxacin-loaded CS-PS/TPP (NCFX) for interaction with bovine hemoglobin (BHb). The interactions of (CFX and NCFX) with redox protein hemoglobin were investigated for the first time through a series of in vitro experimental techniques to provide comprehensive knowledge of the drug−protein binding interactions. Additionally, the effect of inclusion of PS-80 on the CFX-BHb interaction was also studied at different concentrations using fluorescence spectroscopy, ultraviolet−visible (UV−Vis) spectroscopy, and circular dichroism (CD) under physiological conditions. The binding process of CFX and NCFX was spontaneous, and the fluorescence of BHb was quenched due to the static mechanism formation of the (CFX/BHb) and (NCFX/BHb) complexes. Thermodynamic parameters ΔG, ΔH, and ΔS at various temperatures indicate that the hydrogen bonding and van der Waals forces play a major role in the CFX-BHb association.

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Section: Characterizationmentioning

confidence: 99%

Section: Characterizationmentioning

confidence: 99%

In Vitro Hemoglobin Binding and Molecular Docking of Synthesized Chitosan-Based Drug-Carrying Nanocomposite for Ciprofloxacin-HCl Drug Delivery System

Manea,

Qashqoosh,

Rezakazemi

2024

ACS Omega

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“…Copper nanoparticles (CuNPs) also support the wound healing process and find biomedical applications because of their anticancer, antioxidant, anti-inflammatory, and neuroprotective effects [ 14 , 15 ]. Green biosynthesis of Phragmanthera austroarabica extract-derived CuONPs with highly effective antibacterial and antifungal effects against Staphylococcus aureus , Escherichia coli , Penicillium chrysogenum, and Fusarium oxysporum has been reported [ 16 ]. Biogenic methodologies used for the synthesis of nanoparticles are mostly limited to microorganisms and plant extracts, with very few studies conducted on body secretions of living animals.…”

Section: Introductionmentioning

confidence: 99%

Development of CuO Nanoparticles from the Mucus of Garden Snail Cornu aspersum as New Antimicrobial Agents

Dolashka,

Marinova,

Petrov

et al. 2024

Pharmaceuticals

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Several biologically active compounds involved in the green synthesis of silver and gold nanoparticles have been isolated from snail mucus and characterized. This paper presents a successful method for the application of snail mucus from Cornu aspersum as a bioreducing agent of copper sulfate and as a biostabilizer of the copper oxide nanoparticles (CuONPs-Muc) obtained. The synthesis at room temperature and neutral pH yielded nanoparticles with a spherical shape and an average diameter of 150 nm. The structure and properties of CuONPs-Muc were characterized using various methods and techniques, such as ultraviolet–visible spectroscopy (UV–vis), high-performance liquid chromatography (HPLC), one-dimensional polyacrylamide gel electrophoresis (1D-PAGE), up-conversion infrared spectroscopy Fourier transform (FTIR), scanning electron microscopy combined with energy dispersive spectroscopy (SEM/EDS), Raman spectroscopy and imaging, thermogravimetric analysis (TG-DSC), etc. Mucus proteins with molecular weights of 30.691 kDa and 26.549 kDa were identified, which are involved in the biogenic production of CuONPs-Muc. The macromolecular shell of proteins formed around the copper ions contributes to a higher efficiency of the synthesized CuONPs-Muc in inhibiting the bacterial growth of several Gram-positive (Bacillus subtilis NBIMCC2353, Bacillus spizizenii ATCC 6633, Staphylococcus aureus ATCC 6538, Listeria innocua NBIMCC8755) and Gram-negative (Escherichia coli ATCC8739, Salmonella enteitidis NBIMCC8691, Salmonella typhimurium ATCC 14028, Stenotrophomonas maltophilia ATCC 17666) bacteria compared to baseline mucus. The bioorganic synthesis of snail mucus presented here provides CuONPs-Muc with a highly pronounced antimicrobial effect. These results will expand knowledge in the field of natural nanomaterials and their role in emerging dosage forms.

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“…Nanoparticles produced via green synthesis have various applications, including anti-inflammatory and antimicrobial properties, effective medication transport, biological function, targeting tumors, cancer-fighting properties, and absorption into biological systems ( Saddik et al, 2021 , Abu-Dief et al, 2020 ). Additionally, these nanoparticles are utilized in applications such as transistors, magnetic tools, photocatalytic processes, microelectronics, protective coatings against corrosion, electrocatalysts, and within the realm of powder metallurgy ( Alahdal et al, 2023 ; Bordiwala, 2023 ; Rajeshkumar et al, 2023 ). The green synthesis technique utilizes different plant parts, such as roots, stems, leaves, blossoms, and seeds, for material preparation.…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of azithromycin-loaded silver nanoparticles for the treatment of infected wounds

Saddik,

Al-Hakkani,

Abu-Dief

et al. 2024

International Journal of Pharmaceutics: X

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Green synthesis and characterization of copper nanoparticles using Phragmanthera austroarabica extract and their biological/environmental applications

Cited by 25 publications

References 100 publications

In Vitro Hemoglobin Binding and Molecular Docking of Synthesized Chitosan-Based Drug-Carrying Nanocomposite for Ciprofloxacin-HCl Drug Delivery System

In Vitro Hemoglobin Binding and Molecular Docking of Synthesized Chitosan-Based Drug-Carrying Nanocomposite for Ciprofloxacin-HCl Drug Delivery System

Development of CuO Nanoparticles from the Mucus of Garden Snail Cornu aspersum as New Antimicrobial Agents

Formulation and evaluation of azithromycin-loaded silver nanoparticles for the treatment of infected wounds

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