Green synthesis and characterization of iron oxide nanoparticles using Ficus carica (common fig) dried fruit extract

Demirezen, Derya Aksu; Yildiz, Yalçın Şevki; Yılmaz, Şeyda; Yılmaz, Dilek Demirezen

doi:10.1016/j.jbiosc.2018.07.024

Cited by 167 publications

(55 citation statements)

References 19 publications

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“…The zeta potential and PDI of IONPs was −13 mV and 1.000, respectively (Figure b and c). Our results are in correspondence with earlier studies performed on IONPs using Ficus carica . DLS is primarily used to confirm NPs size in the colloidal suspensions in the range of nano‐ and submicron.…”

Section: Resultssupporting

confidence: 91%

Biofabrication of iron oxide nanoparticles by leaf extract of Rhamnus virgata: Characterization and evaluation of cytotoxic, antimicrobial and antioxidant potentials

Abbasi

Iqbal

Mahmood

et al. 2019

Applied Organom Chemis

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In the present study, plant‐mediated synthesis of iron oxide nanoparticles (IONPs) using leaves extract of Rhamnus virgata (Roxb.) as a potential stabilizing, reducing and chelating agent is reported. The biogenic IONPs are extensively characterized for their physical and biological properties. The morphology, structure and physicochemical properties of biogenic IONPs were characterized using ultraviolet spectroscopy, X‐ray diffraction, Fourier transform‐infrared analysis, scanning electron microscopy, energy‐dispersive spectroscopy, transmission electron microscopy, Raman spectroscopy and dynamic light scattering. The Scherrer equation deduced a mean crystallite size of ~20 nm for IONPs. Detailed in vitro biological activities revealed significant therapeutic potentials for IONPs. Potential antibacterial and antifungal activities are reported for IONPs. Bioinspired IONPs have shown potential results against HepG2 cells (IC50: 13.47 μg/ml). Dose‐dependent cytotoxicity assays were revealed against Leishmania tropica (KMH23) promastigotes (IC50: 8.08 μg/ml) and amastigotes (IC50: 20.82 μg/ml) using different concentrations of IONPs (1–200 μg/ml). The cytotoxic activity was also studied using brine shrimps, and their IC50 value was calculated as 32.41 μg/ml. Significant antioxidant [TAC (51.4%), DPPH (79.4%) and total reducing power (62%)], protein kinase and alpha amylase inhibition assays were revealed. The biocompatibility assays using red blood cells (> 200 μg/ml) and macrophages (> 200 μg/ml) confirmed the biosafe nature of IONPs. In conclusion, bioinspired IONPs have shown potential biological applications and should be subjected to further research work to develop their nano‐pharmacological relevance in biomedical applications.

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Section: Resultssupporting

confidence: 91%

Biofabrication of iron oxide nanoparticles by leaf extract of Rhamnus virgata: Characterization and evaluation of cytotoxic, antimicrobial and antioxidant potentials

Abbasi

Iqbal

Mahmood

et al. 2019

Applied Organom Chemis

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“…Hence the addition of B.flabellifer seed coat extract to the precursor solution immediately turns the solution colour from yellow to black, leading to the formation of precipitate. This substantiates the synthesis of iron oxide nanoparticles [37,38]. The synthesized nanoparticles were strongly attracted by an external magnet as shown in the figure 3.…”

Section: Synthesis and Characterization Of Magnetic Iron Oxide Nanopasupporting

confidence: 84%

Biogenic synthesis of magnetic iron oxide nanoparticles using inedible borassus flabellifer seed coat: characterization, antimicrobial, antioxidant activity and in vitro cytotoxicity analysis

Sandhya

Kalaiselvam

2020

Mater. Res. Express

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An environment friendly green synthesis of iron oxide nanoparticles using the seed coat extract of B.flabellifer was investigated. The nanoparticles were characterized using XRD, UV–vis spectroscopy, FTIR, TGA, SEM and EDS. The x-ray diffraction spectrum showed the formation of crystalline inverse spinel magnetite nanoparticles with crystallite size of 35 nm and the UV–vis absorption recorded characteristic peak at 352 nm for iron oxide nanoparticles. The surface functionalization of the nanoparticles was confirmed from the various functional group peaks present in the FTIR spectrum and the thermal decomposition of the synthesized nanoparticles from TGA. The morphological study using SEM showed the formation of hexagonal shaped, well dispersed nanoparticles. The cytocompatibilty of the iron oxide nanoparticles was studied using MTT assay and haemolytic analysis. The antimicrobial activity of the nanoparticles against E. coli, S. aureus, B.subtilis, Shigella, A.niger and Candida albicans were measured and the nanoparticles showed significant activity against all the microorganisms which increased with increase in the nanoparticle concentration. The free radical scavenging activity of the nanoparticles against DPPH, Hydrogen peroxide and hydroxyl radical was performed which showed efficient antioxidant activity.

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“…This value is on the threshold of nanoparticle instability. According to the literature, the zeta potential value of −30 mV is considered to be the most stable range for nanosuspensions [19,20]. The polydispersity index (PDI) obtained for the synthesised nanoprobe was <1, which is in agreement with some literature reports [9,21,22].…”

Section: Discussionsupporting

confidence: 88%

In vivo study of anti‐epidermal growth factor receptor antibody‐based iron oxide nanoparticles (anti‐EGFR‐SPIONs) as a novel MR imaging contrast agent for lung cancer (LLC1) cells detection

Shahbazi‐Gahrouei

Abdi

Shahbazi-Gahrouei

et al. 2020

IET nanobiotechnol.

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Superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anti-epidermal growth factor receptor monoclonal antibody (anti-EGFR-SPIONs) were characterised, and its cytotoxicity effects, ex vivo and in vivo studies on Lewis lung carcinoma (LLC1) cells in C57BL/6 mice were investigated. The broadband at 679.96 cm −1 relates to Fe-O, which verified the formation of the anti-EGFR-Mab with SPIONs was obtained by the FTIR. The TEM images showed spherical shape 20 and 80 nm-sized for nanoparticles and the anti-EGFR-SPIONs, respectively. Results of cell viability at 24 h after incubation with different concentrations of nanoprobe showed it has only a 20% reduction in cell viabilities. The synthesised nanoprobe administered by systemic injection into C57BL/6 mice showed good Fe tumour uptake and satisfied image signal intensity under ex vivo and in vivo conditions. A higher concentration of nanoprobe was achieved compared to non-specific and control, indicating selective delivery of nanoprobe to the tumour. It is concluded that the anti-EGFR-SPIONs was found to be as an MR imaging contrast nanoagent for lung cancer (LLC1) cells detection. 2 Materials and methods Nanomag ®-D-SPIONs 20 nm nanoparticles in suspension (surface PEG-COOH, product code: 79-56-201) were provided from micromod Partikeltechnologie GmbH (Rostock, Germany). All chemicals were purchased from Sigma Chemical Co.

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Green synthesis and characterization of iron oxide nanoparticles using Ficus carica (common fig) dried fruit extract

Cited by 167 publications

References 19 publications

Biofabrication of iron oxide nanoparticles by leaf extract of Rhamnus virgata: Characterization and evaluation of cytotoxic, antimicrobial and antioxidant potentials

Biofabrication of iron oxide nanoparticles by leaf extract of Rhamnus virgata: Characterization and evaluation of cytotoxic, antimicrobial and antioxidant potentials

Biogenic synthesis of magnetic iron oxide nanoparticles using inedible borassus flabellifer seed coat: characterization, antimicrobial, antioxidant activity and in vitro cytotoxicity analysis

In vivo study of anti‐epidermal growth factor receptor antibody‐based iron oxide nanoparticles (anti‐EGFR‐SPIONs) as a novel MR imaging contrast agent for lung cancer (LLC1) cells detection

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