Nanomaterials have been widely used in multi-aspect because of their particular physicochemical properties. However, traditional physical and chemical synthetic methods of nanomaterials are costly, they are easy to produce toxic by-products which are harmful to environment and human health. In recent years, the synthesis of nanomaterials via biological mediated method has shown great potential with the advantage of environmentally friendly, cost-effective and high-efficiency. Plants, microorganisms, and biological extracts are all excellent candidates for biosynthesis. Furthermore, these kinds of bio-genic materials have been applied in many fields such as environment remediation, catalytic reaction, anti-microbsis and anti-tumor. Thus, in order to grasp the research progress and development trend of nanomaterials synthesized by bio-mediated methods, a comprehensive overview is presented based on Web of Science database and bibliometric analysis. The results proved that the number of publications increased year by year from 2010 to 2020, India and China were the main two contributors. Some research institutions and researchers have formed their stable cooperative groups. Keywords analysis showed that the co-occurrence network could be divided into four clusters, "green synthesis," "AgNPs," "AuNPs," "nanoparticles," and "leaf extract" were the most popular words. Moreover, publishing journals, highly cited articles and major disciplines were also studied. The review will provide valuable references for future research.